ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FGF4
Previous Symbol	HSTF1
Symbol Alias	K-FGF, HBGF-4, HST, HST-1, KFGF
Approved Name	fibroblast growth factor 4
Previous Name	heparin secretory transforming protein 1
Name Alias	human stomach cancer, transforming factor from FGF-related oncogene, "kaposi sarcoma oncogene", "transforming protein KS3"
Location	11q13.3
Position	chr11:69587797-69590171, -
External Links	HGNC: 3682 Entrez Gene: 2249 Ensembl: ENSG00000075388 UCSC: uc001opg.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 24)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008286	insulin receptor signaling pathway	Biological Process		32
GO:0008284	positive regulation of cell proliferation	Biological Process	IGI[8663044]	69
GO:0010463	mesenchymal cell proliferation	Biological Process	IDA[11023873]	1
GO:0008543	fibroblast growth factor receptor signaling pathway	Biological Process	IGI[8663044]	26
GO:0007267	cell-cell signaling	Biological Process	TAS[2959959]	38
GO:0007165	signal transduction	Biological Process	TAS[2959959]	171
GO:0008201	heparin binding	Molecular Function		26
GO:0008083	growth factor activity	Molecular Function		25
GO:0051781	positive regulation of cell division	Biological Process		11
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0060561	apoptotic process involved in morphogenesis	Biological Process		2
GO:0060363	cranial suture morphogenesis	Biological Process		1
GO:0035116	embryonic hindlimb morphogenesis	Biological Process		3
GO:0019827	stem cell maintenance	Biological Process		12
GO:0043066	negative regulation of apoptotic process	Biological Process		77
GO:0042475	odontogenesis of dentin-containing tooth	Biological Process		8
GO:0060591	chondroblast differentiation	Biological Process	IDA[17167778]	1
GO:0070374	positive regulation of ERK1 and ERK2 cascade	Biological Process	IDA[17167778]	22
GO:0005104	fibroblast growth factor receptor binding	Molecular Function		4
GO:0005576	extracellular region	Cellular Component		240
GO:0005634	nucleus	Cellular Component		770
GO:0005829	cytosol	Cellular Component		447
GO:0001502	cartilage condensation	Biological Process		5
GO:0001934	positive regulation of protein phosphorylation	Biological Process		22

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05218	Melanoma	12	Melanoma is a form of skin cancer that has a poor prognosis ...... Melanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes. The only known environmental risk factor is exposure to ultraviolet (UV) light and in people with fair skin the risk is greatly increased. Melanoma pathogenesis is also driven by genetic factors. Oncogenic NRAS mutations activate both effector pathways Raf-MEK-ERK and PI3K-Akt. The Raf-MEK-ERK pathway may also be activated via mutations in the BRAF gene. The PI3K-Akt pathway may be activated through loss or mutation of the inhibitory tumor suppressor gene PTEN. These mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. Melanoma development has been shown to be strongly associated with inactivation of the p16INK4a/cyclin dependent kinases 4 and 6/retinoblastoma protein (p16INK4a/CDK4,6/pRb) and p14ARF/human double minute 2/p53 (p14ARF/HMD2/p53) tumor suppressor pathways. MITF and TP53 are implicated in further melanoma progression. More...
hsa04810	Regulation of actin cytoskeleton	48
hsa04010	MAPK signaling pathway	69	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...
hsa05200	Pathways in cancer	52

Genes shared at least 5 GO terms with FGF4 (count: 26)

Gene Symbol	Pathway Count	Pathway List
FGF10	11	insulin receptor signaling pathway; fibroblast growth factor receptor signaling pathway; heparin binding; growth factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; odontogenesis of dentin-containing tooth; positive regulation of ERK1 and ERK2 cascade; fibroblast growth factor receptor binding; extracellular region; nucleus;
FGF9	10	insulin receptor signaling pathway; positive regulation of cell proliferation; fibroblast growth factor receptor signaling pathway; cell-cell signaling; signal transduction; heparin binding; growth factor activity; positive regulation of cell division; fibroblast growth factor receptor binding; extracellular region;
CTGF	9	positive regulation of cell proliferation; fibroblast growth factor receptor signaling pathway; heparin binding; growth factor activity; positive regulation of ERK1 and ERK2 cascade; extracellular region; cytosol; cartilage condensation; positive regulation of protein phosphorylation;
FGF3	8	insulin receptor signaling pathway; positive regulation of cell proliferation; fibroblast growth factor receptor signaling pathway; cell-cell signaling; signal transduction; growth factor activity; positive regulation of cell division; extracellular region;
VEGFA	8	positive regulation of cell proliferation; heparin binding; growth factor activity; positive regulation of cell division; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; extracellular region; positive regulation of protein phosphorylation;
FGF19	7	insulin receptor signaling pathway; positive regulation of cell proliferation; fibroblast growth factor receptor signaling pathway; growth factor activity; positive regulation of ERK1 and ERK2 cascade; fibroblast growth factor receptor binding; extracellular region;
MAPK3	7	insulin receptor signaling pathway; fibroblast growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of ERK1 and ERK2 cascade; nucleus; cytosol; positive regulation of protein phosphorylation;
IGF2	6	insulin receptor signaling pathway; positive regulation of cell proliferation; growth factor activity; positive regulation of cell division; extracellular region; positive regulation of protein phosphorylation;
MAPK1	6	insulin receptor signaling pathway; positive regulation of cell proliferation; fibroblast growth factor receptor signaling pathway; signal transduction; nucleus; cytosol;
PRKAA1	6	insulin receptor signaling pathway; positive regulation of cell proliferation; signal transduction; negative regulation of apoptotic process; nucleus; cytosol;
FLT4	6	positive regulation of cell proliferation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; extracellular region; nucleus; positive regulation of protein phosphorylation;
IL6	6	positive regulation of cell proliferation; growth factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; extracellular region;
NTF3	6	positive regulation of cell proliferation; cell-cell signaling; signal transduction; growth factor activity; positive regulation of transcription from RNA polymerase II promoter; extracellular region;
VEGFB	6	heparin binding; growth factor activity; positive regulation of cell division; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; extracellular region;
INS	5	insulin receptor signaling pathway; positive regulation of cell proliferation; cell-cell signaling; negative regulation of apoptotic process; extracellular region;
PIK3R1	5	insulin receptor signaling pathway; fibroblast growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; cytosol;
BTC	5	positive regulation of cell proliferation; growth factor activity; positive regulation of cell division; negative regulation of apoptotic process; extracellular region;
EDNRA	5	positive regulation of cell proliferation; signal transduction; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of protein phosphorylation;
EREG	5	positive regulation of cell proliferation; cell-cell signaling; growth factor activity; positive regulation of cell division; extracellular region;
RELA	5	positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; nucleus; cytosol;
TBX1	5	positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; odontogenesis of dentin-containing tooth; nucleus; positive regulation of protein phosphorylation;
YAP1	5	positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; nucleus; cytosol;
GSK3B	5	fibroblast growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; nucleus; cytosol;
GDNF	5	signal transduction; growth factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; extracellular region;
MAPK7	5	signal transduction; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; nucleus; cytosol;
PYCARD	5	signal transduction; positive regulation of ERK1 and ERK2 cascade; extracellular region; nucleus; cytosol;

Genes shared at least 2 KEGG pathways with FGF4 (count: 20)

Gene Symbol	Pathway Count	Pathway List
FGF10	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
FGF19	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
FGF3	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
FGF9	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
MAPK1	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
MAPK3	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
PIK3CG	3	Melanoma; Regulation of actin cytoskeleton; Pathways in cancer;
PIK3R1	3	Melanoma; Regulation of actin cytoskeleton; Pathways in cancer;
CRKL	3	Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
BAD	2	Melanoma; Pathways in cancer;
CCND1	2	Melanoma; Pathways in cancer;
PDGFD	2	Melanoma; Regulation of actin cytoskeleton;
APC	2	Regulation of actin cytoskeleton; Pathways in cancer;
FN1	2	Regulation of actin cytoskeleton; Pathways in cancer;
ITGA2	2	Regulation of actin cytoskeleton; Pathways in cancer;
PAK1	2	Regulation of actin cytoskeleton; MAPK signaling pathway;
MAPK9	2	MAPK signaling pathway; Pathways in cancer;
PRKCB	2	MAPK signaling pathway; Pathways in cancer;
RELA	2	MAPK signaling pathway; Pathways in cancer;
TGFBR1	2	MAPK signaling pathway; Pathways in cancer;

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Region: chr11:69587797..69590171 View in gBrowse