ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GDNF
Symbol Alias	ATF1, ATF2, HFB1-GDNF
Approved Name	glial cell derived neurotrophic factor
Name Alias	astrocyte-derived trophic factor, "glial cell line derived neurotrophic factor", "glial derived neurotrophic factor"
Location	5p13.1-p12
Position	chr5:37812779-37839788, -
External Links	HGNC: 4232 Entrez Gene: 2668 Ensembl: ENSG00000168621 UCSC: uc011cpi.1
No. of Studies	2 (significant: 1; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP; Mapped by significant region

Gene related studies (count: 2)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Laurin N, 2008(a)	two low frequency haplotypes demonstrated marginal evidence of association (P-value=0.011 and P-value=0.049), but not supported by the quantitative analyses	Significant
Syed Z, 2007	No evidence of association was seen.	Non-significant

Gene related SNPs (count: 39)

Literature-origin SNPs (count: 12)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs1862574	Chr5:37830577(Fwd)	intron_variant	1(0/1/0)
rs3749692	Chr5:37814148(Fwd)	3_prime_UTR_variant; downstream_gene_variant	1(0/1/0)
rs2910797	Chr5:37820365(Fwd)	intron_variant	1(0/1/0)
rs2973050	Chr5:37817344(Fwd)	intron_variant	1(0/1/0)
rs12514589	Chr5:37842431(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/1/0)
rs2973041	Chr5:37830326(Fwd)	intron_variant	1(0/1/0)
rs12518844	Chr5:37832759(Fwd)	intron_variant	1(0/1/0)
rs7731209	Chr5:37816845(Fwd)	intron_variant	1(0/1/0)
rs3812047	Chr5:37835398(Fwd)	intron_variant; upstream_gene_variant	1(0/1/0)
rs1549250	Chr5:37821221(Fwd)	intron_variant	1(0/1/0)
rs11111	Chr5:37814102(Fwd)	3_prime_UTR_variant; downstream_gene_variant	1(0/1/0)
rs2216711	Chr5:37828844(Fwd)	intron_variant	1(0/1/0)

LD-proxies (count: 27)

rs_ID	Location	Functional Annotation
rs1110149	Chr5:37824053(Fwd)	intron_variant
rs12521946	Chr5:37824784(Fwd)	intron_variant
rs1477359	Chr5:37826889(Fwd)	intron_variant
rs10941370	Chr5:37833419(Fwd)	intron_variant
rs7721618	Chr5:37823282(Fwd)	intron_variant
rs17379771	Chr5:37813591(Fwd)	3_prime_UTR_variant; downstream_gene_variant
rs2910710	Chr5:37811232(Fwd)	downstream_gene_variant
rs2973051	Chr5:37813540(Fwd)	3_prime_UTR_variant; downstream_gene_variant
rs12055296	Chr5:37809265(Fwd)	downstream_gene_variant
rs2973043	Chr5:37823400(Fwd)	intron_variant
rs2910702	Chr5:37828304(Fwd)	intron_variant
rs2975100	Chr5:37841045(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs2910701	Chr5:37829385(Fwd)	intron_variant
rs2910709	Chr5:37811864(Fwd)	downstream_gene_variant
rs3096140	Chr5:37832833(Fwd)	intron_variant
rs2973045	Chr5:37821648(Fwd)	intron_variant
rs2973049	Chr5:37818139(Fwd)	intron_variant
rs13361833	Chr5:37818824(Fwd)	intron_variant
rs884344	Chr5:37824240(Fwd)	intron_variant
rs2910705	Chr5:37822245(Fwd)	intron_variant
rs2910704	Chr5:37827225(Fwd)	intron_variant
rs17379667	Chr5:37810032(Fwd)	downstream_gene_variant
rs16903732	Chr5:37812101(Fwd)	downstream_gene_variant
rs11951867	Chr5:37820201(Fwd)	intron_variant
rs949859	Chr5:37822651(Fwd)	intron_variant
rs17386472	Chr5:37832798(Fwd)	intron_variant
rs2973042	Chr5:37827759(Fwd)	intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5p13	chr5:28900000-42500000	3 (1/1/1)

Gene related GO terms (count: 32)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 32)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048484	enteric nervous system development	Biological Process		4
GO:0048255	mRNA stabilization	Biological Process	IDA[12358785]	3
GO:0051584	regulation of dopamine uptake involved in synaptic transmission	Biological Process	IDA[8493557]	4
GO:0048485	sympathetic nervous system development	Biological Process		5
GO:0060688	regulation of morphogenesis of a branching structure	Biological Process		1
GO:0060676	ureteric bud formation	Biological Process		2
GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	Biological Process		1
GO:0072107	positive regulation of ureteric bud formation	Biological Process	IDA[8657307]	1
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Biological Process	IDA[10921886]	2
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Biological Process	IDA[17229286]	5
GO:0007165	signal transduction	Biological Process	TAS[7830769]	171
GO:0007399	nervous system development	Biological Process	TAS[8637574]	54
GO:0005102	receptor binding	Molecular Function	TAS[10829012]	61
GO:0005576	extracellular region	Cellular Component	IDA[9811930]	240
GO:0008344	adult locomotory behavior	Biological Process	TAS[12358785]	12
GO:0021784	postganglionic parasympathetic nervous system development	Biological Process		1
GO:0007411	axon guidance	Biological Process		65
GO:0008083	growth factor activity	Molecular Function		25
GO:0032770	positive regulation of monooxygenase activity	Biological Process	IDA[12358785]	1
GO:0033603	positive regulation of dopamine secretion	Biological Process	TAS[12358785]	2
GO:0030432	peristalsis	Biological Process		4
GO:0031175	neuron projection development	Biological Process	IDA[15242795]	10
GO:0043524	negative regulation of neuron apoptotic process	Biological Process	IDA[8493557]	19
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[12358785]	131
GO:0042803	protein homodimerization activity	Molecular Function	IDA[8988018]	113
GO:0043066	negative regulation of apoptotic process	Biological Process	TAS[7830769]	77
GO:0001658	branching involved in ureteric bud morphogenesis	Biological Process		8
GO:0001656	metanephros development	Biological Process		7
GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	Biological Process		2
GO:0001941	postsynaptic membrane organization	Biological Process		1
GO:0001759	organ induction	Biological Process		4
GO:0001755	neural crest cell migration	Biological Process	IDA[15242795]	6

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with GDNF (count: 12)

Gene Symbol	Pathway Count	Pathway List
NTF3	9	enteric nervous system development; signal transduction; nervous system development; receptor binding; extracellular region; axon guidance; growth factor activity; negative regulation of neuron apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
VEGFA	7	positive regulation of branching involved in ureteric bud morphogenesis; nervous system development; extracellular region; growth factor activity; positive regulation of transcription from RNA polymerase II promoter; protein homodimerization activity; negative regulation of apoptotic process;
FGF10	6	extracellular region; growth factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; metanephros development; organ induction;
GREM1	5	ureteric bud formation; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of transcription from RNA polymerase II promoter; branching involved in ureteric bud morphogenesis; mesenchymal to epithelial transition involved in metanephros morphogenesis;
CXCL12	5	signal transduction; receptor binding; extracellular region; growth factor activity; negative regulation of apoptotic process;
FGF4	5	signal transduction; extracellular region; growth factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process;
INHA	5	signal transduction; nervous system development; receptor binding; extracellular region; growth factor activity;
BDNF	5	nervous system development; extracellular region; axon guidance; growth factor activity; negative regulation of neuron apoptotic process;
CLCF1	5	receptor binding; extracellular region; growth factor activity; negative regulation of neuron apoptotic process; negative regulation of apoptotic process;
IL6	5	extracellular region; growth factor activity; neuron projection development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process;
NGF	5	extracellular region; adult locomotory behavior; growth factor activity; neuron projection development; negative regulation of neuron apoptotic process;
VEGFB	5	extracellular region; growth factor activity; negative regulation of neuron apoptotic process; protein homodimerization activity; negative regulation of apoptotic process;

Genes shared at least 2 KEGG pathways with GDNF (count: 0)

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Region: chr5:37812779..37839788 View in gBrowse