ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GREM1
Previous Symbol	CKTSF1B1
Symbol Alias	DRM, gremlin, DAND2
Approved Name	gremlin 1
Previous Name	cysteine knot superfamily 1, BMP antagonist 1, "gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)"
Location	15q13.3
Position	chr15:33010175-33026870, +
External Links	HGNC: 2001 Entrez Gene: 26585 Ensembl: ENSG00000166923 UCSC: uc001zhe.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_44	chr15:30688712-32587887 (NCBI Build 36.1 (hg18))	1871368	15q13.3-15q14	Gain	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
15q11.2-13.3	chr15:20700000-33600000	1 (1/0/0)
15q13.3	chr15:31200000-33600000	1 (1/0/0)

Gene related GO terms (count: 48)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 48)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007267	cell-cell signaling	Biological Process		38
GO:0030308	negative regulation of cell growth	Biological Process		21
GO:0006915	apoptotic process	Biological Process		111
GO:0030296	protein tyrosine kinase activator activity	Molecular Function		1
GO:0005615	extracellular space	Cellular Component	NAS[9660951]	126
GO:0030199	collagen fibril organization	Biological Process	IMP[15539560]	5
GO:0005515	protein binding	Molecular Function	IPI[16545136]	910
GO:0016015	morphogen activity	Molecular Function	ISS[9660951]	2
GO:0005125	cytokine activity	Molecular Function		19
GO:0010717	regulation of epithelial to mesenchymal transition	Biological Process	IMP[16816361]	1
GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	Biological Process		2
GO:0009986	cell surface	Cellular Component		70
GO:0009954	proximal/distal pattern formation	Biological Process		5
GO:0003257	positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation	Biological Process	ISS[9660951]	1
GO:0008284	positive regulation of cell proliferation	Biological Process	IDA[16545136]	69
GO:0002092	positive regulation of receptor internalization	Biological Process	ISS[9660951]	7
GO:0043184	vascular endothelial growth factor receptor 2 binding	Molecular Function	ISS[9660951]	2
GO:0002042	cell migration involved in sprouting angiogenesis	Biological Process	ISS[9660951]	2
GO:0042346	positive regulation of NF-kappaB import into nucleus	Biological Process		4
GO:0001658	branching involved in ureteric bud morphogenesis	Biological Process		8
GO:0000902	cell morphogenesis	Biological Process	IDA[16545136]	7
GO:0036122	BMP binding	Molecular Function	ISS[9660951]	2
GO:0033689	negative regulation of osteoblast proliferation	Biological Process	IMP[15539560]	1
GO:0032872	regulation of stress-activated MAPK cascade	Biological Process	ISS[9660951]	4
GO:0030514	negative regulation of BMP signaling pathway	Biological Process	IDA[15539560]; IMP[16816361]	2
GO:0030502	negative regulation of bone mineralization	Biological Process	IMP[15539560]	2
GO:0030326	embryonic limb morphogenesis	Biological Process		8
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process		27
GO:0051893	regulation of focal adhesion assembly	Biological Process		2
GO:0048018	receptor agonist activity	Molecular Function	ISS[9660951]	2
GO:0048263	determination of dorsal identity	Biological Process	IMP[9660951]	2
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	ISS[9660951]	131
GO:0046851	negative regulation of bone remodeling	Biological Process	IMP[15539560]	1
GO:0045766	positive regulation of angiogenesis	Biological Process		12
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process		64
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Biological Process		5
GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis	Biological Process		1
GO:0090027	negative regulation of monocyte chemotaxis	Biological Process		2
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	Biological Process	IDA[15539560]	14
GO:0060676	ureteric bud formation	Biological Process		2
GO:0072331	signal transduction by p53 class mediator	Biological Process	ISS[9660951]	1
GO:0051973	positive regulation of telomerase activity	Biological Process	IDA[16545136]	2
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	Biological Process	IDA[15539560]	1
GO:2000727	positive regulation of cardiac muscle cell differentiation	Biological Process	ISS[9660951]	2
GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	Biological Process	ISS[9660951]	2
GO:0090291	negative regulation of osteoclast proliferation	Biological Process	IMP[15539560]	2
GO:1900158	negative regulation of bone mineralization involved in bone maturation	Biological Process	IMP[15539560]	1
GO:1900155	negative regulation of bone trabecula formation	Biological Process	IMP[15539560]	1

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with GREM1 (count: 10)

Gene Symbol	Pathway Count	Pathway List
VEGFA	13	extracellular space; protein binding; cytokine activity; cell surface; positive regulation of cell proliferation; positive regulation of receptor internalization; vascular endothelial growth factor receptor 2 binding; cell migration involved in sprouting angiogenesis; receptor agonist activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of angiogenesis; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of peptidyl-tyrosine autophosphorylation;
EREG	5	cell-cell signaling; extracellular space; protein binding; positive regulation of cell proliferation; negative regulation of transcription, DNA-dependent;
INS	5	cell-cell signaling; extracellular space; protein binding; positive regulation of cell proliferation; positive regulation of NF-kappaB transcription factor activity;
TNFSF18	5	cell-cell signaling; extracellular space; cytokine activity; cell surface; positive regulation of NF-kappaB transcription factor activity;
GATA6	5	apoptotic process; protein binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of angiogenesis; negative regulation of transcription, DNA-dependent;
PRKD1	5	apoptotic process; protein binding; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of angiogenesis;
IL6	5	extracellular space; cytokine activity; positive regulation of cell proliferation; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
TNFSF4	5	extracellular space; cytokine activity; cell surface; positive regulation of cell proliferation; negative regulation of transcription, DNA-dependent;
RELA	5	protein binding; positive regulation of cell proliferation; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent;
GDNF	5	mesenchymal to epithelial transition involved in metanephros morphogenesis; branching involved in ureteric bud morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of branching involved in ureteric bud morphogenesis; ureteric bud formation;

Genes shared at least 2 KEGG pathways with GREM1 (count: 0)

View in gBrowse

Region: chr15:33010175..33026870 View in gBrowse