ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0045892
Name negative regulation of transcription, DNA-dependent
Type biological process
No. of Genes in ADHDgene  77
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 77)

Literature-origin genes (count: 13)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 22q11.22 1(0/0/1) IMP
FOXP2 forkhead box P2 7q31 1(1/0/0) IDA[18987363]
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 6p12 1(1/0/0) IDA
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2p25 1(0/1/0) IDA[14627819]
ATXN1 ataxin 1 6p23 1(0/0/1) IDA[15016912]
PER1 period circadian clock 1 17p13.1 1(0/1/0) ISS
FOXP1 forkhead box P1 3p14.1 1(0/0/1) IDA
HES1 hes family bHLH transcription factor 1 3q28-q29 1(1/0/0) IDA[12535671]
GSK3B glycogen synthase kinase 3 beta 3q13.3 1(1/0/0) IEA
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 9q21.32 1(1/0/0) IDA[9751710]
ZNF423 zinc finger protein 423 16q12 1(0/0/1) IDA[10660046]
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 12q23 2(2/0/0) IDA[12933792]
EREG epiregulin 4q21.21 1(0/0/1) IDA[14581411]

Genes from other sources Help (count: 64)

Approved Symbol Approved Name Source Evidence[PMID]
RREB1 ras responsive element binding protein 1 Mapped by CNV IEA
KAT5 K(lysine) acetyltransferase 5 Mapped by significant region IDA[17360565]
RSF1 remodeling and spacing factor 1 Mapped by significant region IDA[11944984]
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) Mapped by significant region IDA[9931457]; IMP[18818310]
ZNF263 zinc finger protein 263 Mapped by LD-proxy; Mapped by significant region IEA
LHX1 LIM homeobox 1 Mapped by CNV ISS
CIITA class II, major histocompatibility complex, transactivator Mapped by significant region IDA[19041327]
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) Mapped by LD-proxy IDA[16357133]; ISS
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) Mapped by significant region IMP[8621488]
SPI1 spleen focus forming virus (SFFV) proviral integration oncogene Mapped by LD-proxy IDA
KDM1A lysine (K)-specific demethylase 1A Mapped by LD-proxy IDA[19497860]
DAP death-associated protein Mapped by significant region IMP[1087798]
SNW1 SNW domain containing 1 Mapped by PBA pathway IDA[15878163]
HINFP histone H4 transcription factor Mapped by significant region IDA[17163457]
RASD1 RAS, dexamethasone-induced 1 Mapped by significant region IEA
PRAMENP PRAME N-terminal-like, pseudogene Mapped by LD-proxy IEA
CBX3 chromobox homolog 3 Mapped by CNV; Mapped by significant region IDA[9636147]; IMP[9636147]
STRN3 striatin, calmodulin binding protein 3 Mapped by significant region IDA[11570823]; IEA
PTPRK protein tyrosine phosphatase, receptor type, K Mapped by CNV; Mapped by significant region IDA[18276111]
ZBTB16 zinc finger and BTB domain containing 16 Mapped by significant region IDA[12802276]; NAS[9294197]
MEN1 multiple endocrine neoplasia I Mapped by significant region IDA[12226747]
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta Mapped by significant region IDA[15163635]
EED embryonic ectoderm development Mapped by significant region NAS[9584199]
BRMS1 breast cancer metastasis suppressor 1 Mapped by significant region IDA
ERN2 endoplasmic reticulum to nucleus signaling 2 Mapped by significant region IMP[11175748]
THAP7 THAP domain containing 7 Mapped by CNV IDA[17577209]
UBE2I ubiquitin-conjugating enzyme E2I Mapped by significant region IDA[16631117]
ZNF174 zinc finger protein 174 Mapped by significant region IDA[7673192]
NIPBL Nipped-B homolog (Drosophila) Mapped by significant region IDA[18854353]
GATAD2A GATA zinc finger domain containing 2A Mapped by LD-proxy IDA[12183469]
KAT8 K(lysine) acetyltransferase 8 Mapped by CNV IDA[11742995]
RBPJ recombination signal binding protein for immunoglobulin kappa J region Mapped by CNV IDA[10713164]
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta Mapped by PBA pathway IEA
FOXE1 forkhead box E1 (thyroid transcription factor 2) Mapped by significant region ISS
HSPA8 heat shock 70kDa protein 8 Mapped by significant region IDA[10722728]
GLIS2 GLIS family zinc finger 2 Mapped by significant region ISS
BCLAF1 BCL2-associated transcription factor 1 Mapped by significant region IDA[10330179]; TAS[10330179]
KLF4 Kruppel-like factor 4 (gut) Mapped by significant region IDA[9422764]
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 Mapped by significant region ISS
HMGA1 high mobility group AT-hook 1 Mapped by PBA pathway IMP[16901784]
TNP1 transition protein 1 (during histone to protamine replacement) Mapped by significant region IDA[12743712]
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 Mapped by significant region IDA[12535671]
MPHOSPH8 M-phase phosphoprotein 8 Mapped by significant region IMP
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 Mapped by significant region IMP[16628629]
CCDC85B coiled-coil domain containing 85B Mapped by significant region IDA[17014843]
ZSCAN10 zinc finger and SCAN domain containing 10 Mapped by significant region ISS
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) Mapped by significant region IMP[12805222]
CHMP1A charged multivesicular body protein 1A Mapped by significant region IDA[11559747]
GATA6 GATA binding protein 6 Mapped by significant region IDA[18177748]
WNT11 wingless-type MMTV integration site family, member 11 Mapped by significant region IMP
ZNF24 zinc finger protein 24 Mapped by significant region IDA[10585455]
KCTD1 potassium channel tetramerization domain containing 1 Mapped by significant region IDA[19115315]
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 Mapped by LD-proxy IEA
SOX8 SRY (sex determining region Y)-box 8 Mapped by significant region ISS
HOXA7 homeobox A7 Mapped by significant region IDA[11435435]
FOXG1 forkhead box G1 Mapped by significant region IDA[12657635]
GREM1 gremlin 1, DAN family BMP antagonist Mapped by CNV; Mapped by significant region IEA
CREBZF CREB/ATF bZIP transcription factor Mapped by significant region IMP[15705566]
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A Mapped by significant region IDA[17350185]
DAXX death-domain associated protein Mapped by PBA pathway IDA[10698492]
RCOR2 REST corepressor 2 Mapped by significant region IEA
MYB v-myb avian myeloblastosis viral oncogene homolog Mapped by significant region IMP
SBNO2 strawberry notch homolog 2 (Drosophila) Mapped by CNV IMP[18025162]
BASP1 brain abundant, membrane attached signal protein 1 Mapped by significant region IDA[19050011]; IMP[14701728]