ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RREB1
Symbol Alias	HNT
Approved Name	ras responsive element binding protein 1
Name Alias	"hindsight homolog (drosophila)"
Location	6p25
Position	chr6:7107830-7252213, 1
External Links	HGNC: 10449 Entrez Gene: 6239 Ensembl: ENSG00000124782 UCSC: uc003mxb.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_78	chr6:6859406-7198730 (NCBI Build 35 (hg17))	339325	6p25.1-6p24.3	Duplication	Paternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045892	negative regulation of transcription, DNA-dependent	biological process	IEA	77
GO:0016604	nuclear body	cellular component	TAS[9305772]	5
GO:0005634	nucleus	cellular component	TAS[9305772]	877
GO:0008270	zinc ion binding	molecular function	IEA	367
GO:0005737	cytoplasm	cellular component	TAS[9305772]	781
GO:0003677	DNA binding	molecular function	IEA	257
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	148
GO:0045893	positive regulation of transcription, DNA-dependent	biological process	TAS[9305772]	89
GO:0006355	regulation of transcription, DNA-dependent	biological process	TAS[9305772]	182
GO:0007275	multicellular organismal development	biological process	TAS[8816445]	79
GO:0006366	transcription from RNA polymerase II promoter	biological process	TAS[8816445]	63
GO:0016607	nuclear speck	cellular component	IEA	40
GO:0007265	Ras protein signal transduction	biological process	TAS[8816445]	15

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with RREB1 (count: 58)

Gene Symbol	Pathway Count	Pathway List
HINFP	7	negative regulation of transcription, DNA-dependent; nucleus; zinc ion binding; DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent;
ZNF263	7	negative regulation of transcription, DNA-dependent; nucleus; zinc ion binding; cytoplasm; DNA binding; sequence-specific DNA binding transcription factor activity; regulation of transcription, DNA-dependent;
ZBTB16	7	negative regulation of transcription, DNA-dependent; nuclear body; nucleus; zinc ion binding; DNA binding; positive regulation of transcription, DNA-dependent; nuclear speck;
CREBBP	7	nuclear body; nucleus; zinc ion binding; cytoplasm; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent;
GLIS2	6	negative regulation of transcription, DNA-dependent; nucleus; zinc ion binding; cytoplasm; positive regulation of transcription, DNA-dependent; nuclear speck;
TFAP2B	6	negative regulation of transcription, DNA-dependent; nucleus; DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent;
RELA	6	negative regulation of transcription, DNA-dependent; nucleus; cytoplasm; DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent;
HMGA1	6	negative regulation of transcription, DNA-dependent; nucleus; DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent;
SOX8	6	negative regulation of transcription, DNA-dependent; nucleus; cytoplasm; DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent;
LHX1	6	negative regulation of transcription, DNA-dependent; nucleus; zinc ion binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter;
TAF4B	6	nucleus; cytoplasm; DNA binding; sequence-specific DNA binding transcription factor activity; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter;
HOXB1	6	nucleus; cytoplasm; DNA binding; sequence-specific DNA binding transcription factor activity; regulation of transcription, DNA-dependent; multicellular organismal development;
TRIM22	6	nucleus; zinc ion binding; cytoplasm; sequence-specific DNA binding transcription factor activity; regulation of transcription, DNA-dependent; nuclear speck;
KLF4	5	negative regulation of transcription, DNA-dependent; zinc ion binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter;
HES1	5	negative regulation of transcription, DNA-dependent; nucleus; cytoplasm; DNA binding; sequence-specific DNA binding transcription factor activity;
ZNF24	5	negative regulation of transcription, DNA-dependent; nucleus; zinc ion binding; DNA binding; sequence-specific DNA binding transcription factor activity;
GATAD2A	5	negative regulation of transcription, DNA-dependent; nucleus; zinc ion binding; sequence-specific DNA binding transcription factor activity; nuclear speck;
MYB	5	negative regulation of transcription, DNA-dependent; DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent;
ZNF423	5	negative regulation of transcription, DNA-dependent; nucleus; zinc ion binding; DNA binding; positive regulation of transcription, DNA-dependent;
FOXP2	5	negative regulation of transcription, DNA-dependent; zinc ion binding; cytoplasm; DNA binding; sequence-specific DNA binding transcription factor activity;
GATA6	5	negative regulation of transcription, DNA-dependent; nucleus; zinc ion binding; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter;
ZNF174	5	negative regulation of transcription, DNA-dependent; nucleus; zinc ion binding; cytoplasm; sequence-specific DNA binding transcription factor activity;
FOXE1	5	negative regulation of transcription, DNA-dependent; nucleus; DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent;
RBPJ	5	negative regulation of transcription, DNA-dependent; nucleus; cytoplasm; DNA binding; sequence-specific DNA binding transcription factor activity;
ID2	5	negative regulation of transcription, DNA-dependent; nucleus; cytoplasm; positive regulation of transcription, DNA-dependent; multicellular organismal development;
GRHL1	5	nucleus; cytoplasm; DNA binding; regulation of transcription, DNA-dependent; multicellular organismal development;
ZNF77	5	nucleus; zinc ion binding; cytoplasm; DNA binding; regulation of transcription, DNA-dependent;
ZNF131	5	nucleus; zinc ion binding; DNA binding; sequence-specific DNA binding transcription factor activity; regulation of transcription, DNA-dependent;
ZNF74	5	nucleus; zinc ion binding; DNA binding; regulation of transcription, DNA-dependent; multicellular organismal development;
ZNF287	5	nucleus; zinc ion binding; DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent;
ZFR	5	nucleus; zinc ion binding; cytoplasm; DNA binding; multicellular organismal development;
CREB5	5	nucleus; zinc ion binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter;
TADA2A	5	nucleus; zinc ion binding; DNA binding; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter;
PTTG1	5	nucleus; cytoplasm; sequence-specific DNA binding transcription factor activity; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter;
IKZF1	5	nucleus; zinc ion binding; cytoplasm; DNA binding; sequence-specific DNA binding transcription factor activity;
CBL	5	nucleus; zinc ion binding; cytoplasm; sequence-specific DNA binding transcription factor activity; regulation of transcription, DNA-dependent;
ZNF396	5	nucleus; zinc ion binding; cytoplasm; DNA binding; sequence-specific DNA binding transcription factor activity;
IRF7	5	nucleus; cytoplasm; DNA binding; positive regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter;
ZNF215	5	nucleus; zinc ion binding; DNA binding; sequence-specific DNA binding transcription factor activity; regulation of transcription, DNA-dependent;
APBB1	5	nucleus; cytoplasm; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; nuclear speck;
ZFP37	5	nucleus; zinc ion binding; DNA binding; sequence-specific DNA binding transcription factor activity; regulation of transcription, DNA-dependent;
ZNF202	5	nucleus; zinc ion binding; DNA binding; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter;
ETS1	5	nucleus; DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter;
MAPK1	5	nucleus; cytoplasm; DNA binding; positive regulation of transcription, DNA-dependent; Ras protein signal transduction;
ZNF169	5	nucleus; zinc ion binding; DNA binding; sequence-specific DNA binding transcription factor activity; regulation of transcription, DNA-dependent;
EBF1	5	nucleus; DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; multicellular organismal development;
IGHMBP2	5	nucleus; zinc ion binding; cytoplasm; DNA binding; regulation of transcription, DNA-dependent;
ZNF367	5	nucleus; zinc ion binding; cytoplasm; DNA binding; sequence-specific DNA binding transcription factor activity;
DEAF1	5	nucleus; zinc ion binding; cytoplasm; DNA binding; transcription from RNA polymerase II promoter;
ZNF521	5	nucleus; zinc ion binding; DNA binding; regulation of transcription, DNA-dependent; multicellular organismal development;
PNN	5	nucleus; cytoplasm; DNA binding; regulation of transcription, DNA-dependent; nuclear speck;
ZNF397	5	nucleus; zinc ion binding; cytoplasm; DNA binding; sequence-specific DNA binding transcription factor activity;
LMX1B	5	nucleus; zinc ion binding; sequence-specific DNA binding transcription factor activity; regulation of transcription, DNA-dependent; multicellular organismal development;
FOXL1	5	nucleus; DNA binding; sequence-specific DNA binding transcription factor activity; regulation of transcription, DNA-dependent; multicellular organismal development;
ZNF70	5	nucleus; zinc ion binding; DNA binding; sequence-specific DNA binding transcription factor activity; regulation of transcription, DNA-dependent;
KMT2A	5	nucleus; zinc ion binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter;
SSRP1	5	nucleus; cytoplasm; DNA binding; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter;
GFI1B	5	nucleus; zinc ion binding; DNA binding; multicellular organismal development; transcription from RNA polymerase II promoter;

Genes shared at least 2 KEGG pathways with RREB1 (count: 0)

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Region: chr6:7107830..7252213 View in gBrowse