ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CREB5
Symbol Alias	H_GS165L15.1, CRE-BPA
Approved Name	cAMP responsive element binding protein 5
Name Alias	"cAMP response element binding protein CRE-Bpa"
Location	7p15
Position	chr7:28338940-28865511, 1
External Links	HGNC: 16844 Entrez Gene: 9586 Ensembl: ENSG00000146592 UCSC: uc003szr.3
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lesch KP, 2008	Trend associated SNP was mapped in this gene.	Trend

Gene related SNPs (count: 7)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs2237349	chr7:28762963(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/0/1)

LD-proxies (count: 6)

rs_ID	Location	Functional Annotation
rs10486591	chr7:28766878(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs6972081	chr7:28749046(Fwd)	intron_variant; nc_transcript_variant
rs9690752	chr7:28730571(Fwd)	intron_variant; nc_transcript_variant
rs4719947	chr7:28734192(Fwd)	intron_variant; nc_transcript_variant
rs2299110	chr7:28759900(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs2237346	chr7:28760077(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005515	protein binding	molecular function	IPI[8440710]	1015
GO:0043565	sequence-specific DNA binding	molecular function	IEA	80
GO:0008270	zinc ion binding	molecular function	IEA	367
GO:0005634	nucleus	cellular component	IC[8378084]	877
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	molecular function	IEA	8
GO:0060612	adipose tissue development	biological process	IEA	8
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IDA[8378084]	148
GO:0006366	transcription from RNA polymerase II promoter	biological process	TAS[8378084]	63
GO:0045893	positive regulation of transcription, DNA-dependent	biological process	IDA[8378084]	89
GO:0045444	fat cell differentiation	biological process	IEA	12

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05215	Prostate cancer	16

Genes shared at least 5 GO terms with CREB5 (count: 20)

Gene Symbol	Pathway Count	Pathway List
TFAP2B	7	protein binding; sequence-specific DNA binding; nucleus; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; fat cell differentiation;
KMT2A	6	protein binding; zinc ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent;
ETS1	6	protein binding; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent;
LHX1	6	sequence-specific DNA binding; zinc ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent;
KLF4	6	zinc ion binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; fat cell differentiation;
GATAD2A	5	protein binding; sequence-specific DNA binding; zinc ion binding; nucleus; sequence-specific DNA binding transcription factor activity;
GATA6	5	protein binding; zinc ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter;
LMX1B	5	protein binding; sequence-specific DNA binding; zinc ion binding; nucleus; sequence-specific DNA binding transcription factor activity;
RELA	5	protein binding; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent;
MTA2	5	protein binding; sequence-specific DNA binding; zinc ion binding; nucleus; sequence-specific DNA binding transcription factor activity;
MEIS2	5	protein binding; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter;
HINFP	5	protein binding; zinc ion binding; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent;
CREBBP	5	protein binding; zinc ion binding; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent;
HNF1B	5	protein binding; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent;
ZNF24	5	protein binding; sequence-specific DNA binding; zinc ion binding; nucleus; sequence-specific DNA binding transcription factor activity;
FEV	5	sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent;
FOXC2	5	sequence-specific DNA binding; nucleus; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent;
LHX2	5	sequence-specific DNA binding; zinc ion binding; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent;
RREB1	5	zinc ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent;
SOX8	5	nucleus; adipose tissue development; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; fat cell differentiation;

Genes shared at least 2 KEGG pathways with CREB5 (count: 0)

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Region: chr7:28338940..28865511 View in gBrowse