ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	LMX1B
Previous Symbol	NPS1
Approved Name	LIM homeobox transcription factor 1, beta
Location	9q33.3
Position	chr9:129376722-129463311, +
External Links	HGNC: 6654 Entrez Gene: 4010 Ensembl: ENSG00000136944 UCSC: uc004bqi.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q33	chr9:117700000-130300000	2 (1/1/0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IDA[10767331]	158
GO:0005515	protein binding	Molecular Function	IPI[12792813]	910
GO:0005634	nucleus	Cellular Component	IDA[10767331]	770
GO:0009953	dorsal/ventral pattern formation	Biological Process		12
GO:0030182	neuron differentiation	Biological Process		9
GO:0007275	multicellular organismal development	Biological Process	NAS[9618165]	71
GO:0008270	zinc ion binding	Molecular Function		323
GO:0001701	in utero embryonic development	Biological Process	NAS[12792813]	32
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	IDA[10767331]	132

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with LMX1B (count: 49)

Gene Symbol	Pathway Count	Pathway List
HINFP	7	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; nucleus; zinc ion binding; in utero embryonic development; sequence-specific DNA binding transcription factor activity;
HOXA1	6	transcription, DNA-dependent; protein binding; nucleus; multicellular organismal development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
HOXA9	6	transcription, DNA-dependent; protein binding; nucleus; multicellular organismal development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
HOXB1	6	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; multicellular organismal development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
LHX2	6	transcription, DNA-dependent; nucleus; dorsal/ventral pattern formation; zinc ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
TSHZ2	6	transcription, DNA-dependent; nucleus; multicellular organismal development; zinc ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
ZNF24	6	transcription, DNA-dependent; protein binding; nucleus; zinc ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
ATF6	5	transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
BATF2	5	transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
BIRC2	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; nucleus; zinc ion binding;
CREBZF	5	transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
CTNND2	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; nucleus; multicellular organismal development;
ETS1	5	transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
FLII	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; nucleus; multicellular organismal development;
HMGA1	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding transcription factor activity;
HOXA10	5	transcription, DNA-dependent; protein binding; multicellular organismal development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
HOXA11	5	transcription, DNA-dependent; dorsal/ventral pattern formation; multicellular organismal development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
HOXA2	5	transcription, DNA-dependent; nucleus; dorsal/ventral pattern formation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
HOXA5	5	transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
IGHMBP2	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; nucleus; zinc ion binding;
IKZF1	5	transcription, DNA-dependent; nucleus; zinc ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
KDM1A	5	transcription, DNA-dependent; protein binding; nucleus; in utero embryonic development; sequence-specific DNA binding transcription factor activity;
LHX6	5	transcription, DNA-dependent; nucleus; zinc ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
LPXN	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; nucleus; zinc ion binding;
MYB	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; in utero embryonic development; sequence-specific DNA binding transcription factor activity;
NCOR1	5	transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
NR4A2	5	transcription, DNA-dependent; protein binding; nucleus; zinc ion binding; sequence-specific DNA binding;
PCGF3	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; nucleus; zinc ion binding;
POU2F3	5	transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
PRDM1	5	transcription, DNA-dependent; nucleus; zinc ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
SREBF1	5	transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
TRIM22	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; zinc ion binding; sequence-specific DNA binding transcription factor activity;
ZFP37	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; zinc ion binding; sequence-specific DNA binding transcription factor activity;
ZNF169	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; zinc ion binding; sequence-specific DNA binding transcription factor activity;
ZNF215	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; zinc ion binding; sequence-specific DNA binding transcription factor activity;
ZNF263	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; zinc ion binding; sequence-specific DNA binding transcription factor activity;
ZNF521	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; multicellular organismal development; zinc ion binding;
ZNF646	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; nucleus; zinc ion binding;
ZNF70	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; zinc ion binding; sequence-specific DNA binding transcription factor activity;
ZNF74	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; multicellular organismal development; zinc ion binding;
CBL	5	regulation of transcription, DNA-dependent; protein binding; nucleus; zinc ion binding; sequence-specific DNA binding transcription factor activity;
FOXD4	5	regulation of transcription, DNA-dependent; nucleus; multicellular organismal development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
FOXG1	5	regulation of transcription, DNA-dependent; protein binding; nucleus; dorsal/ventral pattern formation; sequence-specific DNA binding;
FOXL1	5	regulation of transcription, DNA-dependent; nucleus; multicellular organismal development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
RREB1	5	regulation of transcription, DNA-dependent; nucleus; multicellular organismal development; zinc ion binding; sequence-specific DNA binding transcription factor activity;
CREB5	5	protein binding; nucleus; zinc ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
GATA6	5	protein binding; nucleus; zinc ion binding; in utero embryonic development; sequence-specific DNA binding transcription factor activity;
MTA2	5	protein binding; nucleus; zinc ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
LHX1	5	nucleus; dorsal/ventral pattern formation; zinc ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;

Genes shared at least 2 KEGG pathways with LMX1B (count: 0)

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Region: chr9:129376722..129463311 View in gBrowse