ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PRDM1
Previous Symbol	BLIMP1
Symbol Alias	PRDI-BF1
Approved Name	PR domain containing 1, with ZNF domain
Location	6q21
Position	chr6:106534195-106557814, +
External Links	HGNC: 9346 Entrez Gene: 639 Ensembl: ENSG00000057657 UCSC: uc003prd.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_65	chr6:106626358-107036437 (NCBI Build 35 (hg17))	410080	6q21	Duplication	Paternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	Biological Process		1
GO:0030889	negative regulation of B cell proliferation	Biological Process		4
GO:0010628	positive regulation of gene expression	Biological Process		28
GO:0008270	zinc ion binding	Molecular Function		323
GO:0045579	positive regulation of B cell differentiation	Biological Process		3
GO:0045165	cell fate commitment	Biological Process		4
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0042826	histone deacetylase binding	Molecular Function		10
GO:0005634	nucleus	Cellular Component		770
GO:0005737	cytoplasm	Cellular Component		690
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0007281	germ cell development	Biological Process		7
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78
GO:0001892	embryonic placenta development	Biological Process		4
GO:0001893	maternal placenta development	Biological Process		2
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	TAS[1851123]	132

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PRDM1 (count: 37)

Gene Symbol	Pathway Count	Pathway List
IKZF1	7	zinc ion binding; sequence-specific DNA binding; nucleus; cytoplasm; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
HEY2	7	cell fate commitment; sequence-specific DNA binding; histone deacetylase binding; nucleus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
NCOR1	7	sequence-specific DNA binding; histone deacetylase binding; nucleus; cytoplasm; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
HES1	6	sequence-specific DNA binding; histone deacetylase binding; nucleus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
HINFP	5	positive regulation of gene expression; zinc ion binding; nucleus; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
TFAP2A	5	positive regulation of gene expression; sequence-specific DNA binding; nucleus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
ISL1	5	zinc ion binding; nucleus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
LHX2	5	zinc ion binding; sequence-specific DNA binding; nucleus; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
LHX6	5	zinc ion binding; sequence-specific DNA binding; nucleus; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
LMX1B	5	zinc ion binding; sequence-specific DNA binding; nucleus; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
MTA2	5	zinc ion binding; sequence-specific DNA binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
MTA3	5	zinc ion binding; sequence-specific DNA binding; nucleus; cytoplasm; sequence-specific DNA binding transcription factor activity;
NR4A2	5	zinc ion binding; sequence-specific DNA binding; nucleus; cytoplasm; transcription, DNA-dependent;
PHF1	5	zinc ion binding; nucleus; cytoplasm; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
TRIM22	5	zinc ion binding; nucleus; cytoplasm; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
TSHZ2	5	zinc ion binding; sequence-specific DNA binding; nucleus; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
ZNF189	5	zinc ion binding; nucleus; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
ZNF24	5	zinc ion binding; sequence-specific DNA binding; nucleus; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
ZNF263	5	zinc ion binding; nucleus; cytoplasm; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
ZNF367	5	zinc ion binding; nucleus; cytoplasm; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
ZNF396	5	zinc ion binding; nucleus; cytoplasm; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
ZNF397	5	zinc ion binding; nucleus; cytoplasm; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
ONECUT2	5	cell fate commitment; sequence-specific DNA binding; nucleus; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
BSX	5	sequence-specific DNA binding; nucleus; cytoplasm; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
DRAP1	5	sequence-specific DNA binding; nucleus; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
HOXA2	5	sequence-specific DNA binding; nucleus; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
HOXA7	5	sequence-specific DNA binding; nucleus; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
HOXA9	5	sequence-specific DNA binding; nucleus; cytoplasm; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
HOXB1	5	sequence-specific DNA binding; nucleus; cytoplasm; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
IRX3	5	sequence-specific DNA binding; nucleus; cytoplasm; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
MAF	5	sequence-specific DNA binding; nucleus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
MEN1	5	sequence-specific DNA binding; nucleus; cytoplasm; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter;
POU2F3	5	sequence-specific DNA binding; nucleus; cytoplasm; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
SREBF1	5	sequence-specific DNA binding; nucleus; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
LPIN1	5	histone deacetylase binding; nucleus; cytoplasm; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter;
TCF25	5	nucleus; cytoplasm; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
TFEB	5	nucleus; cytoplasm; transcription, DNA-dependent; embryonic placenta development; sequence-specific DNA binding transcription factor activity;

Genes shared at least 2 KEGG pathways with PRDM1 (count: 0)

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Region: chr6:106534195..106557814 View in gBrowse