ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	LPIN1
Symbol Alias	KIAA0188
Approved Name	lipin 1
Location	2p25.1
Position	chr2:11864475-11967535, +
External Links	HGNC: 13345 Entrez Gene: 23175 Ensembl: ENSG00000134324 UCSC: uc002rbt.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2p25.1	chr2:7100000-12200000	2 (1/0/1)

Gene related GO terms (count: 31)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 31)

ID	Name	Type	No. of Genes in ADHDgene
GO:0042975	peroxisome proliferator activated receptor binding	Molecular Function	3
GO:0044255	cellular lipid metabolic process	Biological Process	30
GO:0044281	small molecule metabolic process	Biological Process	248
GO:0045598	regulation of fat cell differentiation	Biological Process	2
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	131
GO:0046474	glycerophospholipid biosynthetic process	Biological Process	30
GO:0006644	phospholipid metabolic process	Biological Process	59
GO:0006642	triglyceride mobilization	Biological Process	2
GO:0006351	transcription, DNA-dependent	Biological Process	247
GO:0005829	cytosol	Cellular Component	447
GO:0009062	fatty acid catabolic process	Biological Process	1
GO:0008195	phosphatidate phosphatase activity	Molecular Function	1
GO:0006656	phosphatidylcholine biosynthetic process	Biological Process	6
GO:0006646	phosphatidylethanolamine biosynthetic process	Biological Process	2
GO:0031529	ruffle organization	Biological Process	5
GO:0031100	organ regeneration	Biological Process	11
GO:0031065	positive regulation of histone deacetylation	Biological Process	4
GO:0019432	triglyceride biosynthetic process	Biological Process	12
GO:0042826	histone deacetylase binding	Molecular Function	10
GO:0032869	cellular response to insulin stimulus	Biological Process	7
GO:0031965	nuclear membrane	Cellular Component	27
GO:0031532	actin cytoskeleton reorganization	Biological Process	5
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	78
GO:0003674	molecular_function	Molecular Function	126
GO:0003713	transcription coactivator activity	Molecular Function	52
GO:0000266	mitochondrial fission	Biological Process	2
GO:0001085	RNA polymerase II transcription factor binding	Molecular Function	10
GO:0005737	cytoplasm	Cellular Component	690
GO:0005789	endoplasmic reticulum membrane	Cellular Component	140
GO:0005634	nucleus	Cellular Component	770
GO:0005667	transcription factor complex	Cellular Component	51

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with LPIN1 (count: 47)

Gene Symbol	Pathway Count	Pathway List
NCOR1	9	cellular lipid metabolic process; small molecule metabolic process; transcription, DNA-dependent; positive regulation of histone deacetylation; histone deacetylase binding; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; transcription factor complex;
MED1	8	peroxisome proliferator activated receptor binding; cellular lipid metabolic process; small molecule metabolic process; positive regulation of transcription from RNA polymerase II promoter; organ regeneration; negative regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; nucleus;
KAT5	7	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytosol; negative regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; nucleus; transcription factor complex;
DGAT2	6	cellular lipid metabolic process; small molecule metabolic process; glycerophospholipid biosynthetic process; phospholipid metabolic process; triglyceride biosynthetic process; endoplasmic reticulum membrane;
LPCAT1	6	cellular lipid metabolic process; small molecule metabolic process; glycerophospholipid biosynthetic process; phospholipid metabolic process; triglyceride biosynthetic process; endoplasmic reticulum membrane;
LPCAT4	6	cellular lipid metabolic process; small molecule metabolic process; glycerophospholipid biosynthetic process; phospholipid metabolic process; triglyceride biosynthetic process; endoplasmic reticulum membrane;
NCOA6	6	cellular lipid metabolic process; small molecule metabolic process; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; nucleus; transcription factor complex;
NCOR2	6	cellular lipid metabolic process; small molecule metabolic process; transcription, DNA-dependent; histone deacetylase binding; negative regulation of transcription from RNA polymerase II promoter; nucleus;
NPAS2	6	cellular lipid metabolic process; small molecule metabolic process; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytosol; transcription factor complex;
SMARCD3	6	cellular lipid metabolic process; small molecule metabolic process; transcription, DNA-dependent; transcription coactivator activity; cytoplasm; nucleus;
CHKA	6	small molecule metabolic process; glycerophospholipid biosynthetic process; phospholipid metabolic process; cytosol; phosphatidylcholine biosynthetic process; phosphatidylethanolamine biosynthetic process;
PRKD1	6	small molecule metabolic process; positive regulation of transcription from RNA polymerase II promoter; phospholipid metabolic process; cytosol; cytoplasm; nucleus;
HES1	6	regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; histone deacetylase binding; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus;
KDM1A	6	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II transcription factor binding; nucleus; transcription factor complex;
MEN1	6	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytosol; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus;
NRIP1	6	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; histone deacetylase binding; negative regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; nucleus;
SREBF1	6	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; positive regulation of histone deacetylation; negative regulation of transcription from RNA polymerase II promoter; endoplasmic reticulum membrane; nucleus;
YAP1	6	positive regulation of transcription from RNA polymerase II promoter; cytosol; transcription coactivator activity; cytoplasm; nucleus; transcription factor complex;
HMGA1	5	peroxisome proliferator activated receptor binding; transcription, DNA-dependent; cytosol; nucleus; transcription factor complex;
APOA1	5	cellular lipid metabolic process; small molecule metabolic process; phosphatidylcholine biosynthetic process; organ regeneration; nucleus;
GRHL1	5	cellular lipid metabolic process; small molecule metabolic process; transcription, DNA-dependent; cytoplasm; nucleus;
ACHE	5	small molecule metabolic process; glycerophospholipid biosynthetic process; phospholipid metabolic process; phosphatidylcholine biosynthetic process; nucleus;
APRT	5	small molecule metabolic process; cytosol; cellular response to insulin stimulus; cytoplasm; nucleus;
MTMR2	5	small molecule metabolic process; phospholipid metabolic process; cytosol; cytoplasm; nucleus;
PEMT	5	small molecule metabolic process; glycerophospholipid biosynthetic process; phospholipid metabolic process; phosphatidylcholine biosynthetic process; endoplasmic reticulum membrane;
PLA2G1B	5	small molecule metabolic process; positive regulation of transcription from RNA polymerase II promoter; glycerophospholipid biosynthetic process; phospholipid metabolic process; cellular response to insulin stimulus;
PLA2G4C	5	small molecule metabolic process; glycerophospholipid biosynthetic process; phospholipid metabolic process; cytosol; endoplasmic reticulum membrane;
PLA2G6	5	small molecule metabolic process; glycerophospholipid biosynthetic process; phospholipid metabolic process; cytosol; cytoplasm;
PNPLA3	5	small molecule metabolic process; glycerophospholipid biosynthetic process; phospholipid metabolic process; triglyceride biosynthetic process; endoplasmic reticulum membrane;
PSMC3	5	small molecule metabolic process; cytosol; transcription coactivator activity; cytoplasm; nucleus;
BSX	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; nucleus; transcription factor complex;
GATA6	5	positive regulation of transcription from RNA polymerase II promoter; phospholipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription factor complex;
GSK3B	5	positive regulation of transcription from RNA polymerase II promoter; cytosol; RNA polymerase II transcription factor binding; cytoplasm; nucleus;
HEY2	5	positive regulation of transcription from RNA polymerase II promoter; histone deacetylase binding; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus;
IKZF1	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus;
IRF7	5	positive regulation of transcription from RNA polymerase II promoter; cytosol; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus;
MTA2	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II transcription factor binding; nucleus; transcription factor complex;
NFATC4	5	positive regulation of transcription from RNA polymerase II promoter; cytosol; transcription coactivator activity; cytoplasm; transcription factor complex;
POU2F3	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; nucleus; transcription factor complex;
RELA	5	positive regulation of transcription from RNA polymerase II promoter; cytosol; cytoplasm; nucleus; transcription factor complex;
TFAP2A	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; cytoplasm; nucleus;
TFEB	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; nucleus; transcription factor complex;
UBE3A	5	positive regulation of transcription from RNA polymerase II promoter; cytosol; transcription coactivator activity; cytoplasm; nucleus;
VGLL2	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; transcription coactivator activity; cytoplasm; nucleus;
NEDD4L	5	transcription, DNA-dependent; cytosol; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus;
PRDM1	5	transcription, DNA-dependent; histone deacetylase binding; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus;
PAK1	5	cytosol; cellular response to insulin stimulus; nuclear membrane; actin cytoskeleton reorganization; cytoplasm;

Genes shared at least 2 KEGG pathways with LPIN1 (count: 0)

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Region: chr2:11864475..11967535 View in gBrowse