ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NPAS2
Symbol Alias	MOP4, PASD4, bHLHe9
Approved Name	neuronal PAS domain protein 2
Location	2q11.2
Position	chr2:101436613-101613291, +
External Links	HGNC: 7895 Entrez Gene: 4862 Ensembl: ENSG00000170485 UCSC: uc002tap.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_57	chr2:100194339-100878975 (NCBI Build 36.1 (hg18))	684637	2q11.2	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0007417	central nervous system development	Biological Process	TAS[9012850]	22
GO:0042745	circadian sleep/wake cycle	Biological Process		2
GO:0044255	cellular lipid metabolic process	Biological Process		30
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0045475	locomotor rhythm	Biological Process		1
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IGI[9576906]	131
GO:0046983	protein dimerization activity	Molecular Function		26
GO:0003677	DNA binding	Molecular Function	IPI[9576906]	220
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function		132
GO:0004871	signal transducer activity	Molecular Function		49
GO:0005667	transcription factor complex	Cellular Component	IPI[9576906]	51
GO:0005829	cytosol	Cellular Component		447
GO:0051879	Hsp90 protein binding	Molecular Function	IDA[9079689]	4

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04710	Circadian rhythm - mammal	6

Genes shared at least 5 GO terms with NPAS2 (count: 13)

Gene Symbol	Pathway Count	Pathway List
LPIN1	6	transcription, DNA-dependent; cellular lipid metabolic process; small molecule metabolic process; positive regulation of transcription from RNA polymerase II promoter; transcription factor complex; cytosol;
CLOCK	6	positive regulation of transcription from RNA polymerase II promoter; protein dimerization activity; sequence-specific DNA binding transcription factor activity; signal transducer activity; transcription factor complex; cytosol;
BARX2	5	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex;
E2F5	5	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex;
ETS1	5	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex;
HES6	5	transcription, DNA-dependent; protein dimerization activity; DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex;
HMGA1	5	transcription, DNA-dependent; DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; cytosol;
NCOR1	5	transcription, DNA-dependent; cellular lipid metabolic process; small molecule metabolic process; sequence-specific DNA binding transcription factor activity; transcription factor complex;
NPAS4	5	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; DNA binding; signal transducer activity; transcription factor complex;
POU2F3	5	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; protein dimerization activity; sequence-specific DNA binding transcription factor activity; transcription factor complex;
SREBF1	5	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; protein dimerization activity; DNA binding; sequence-specific DNA binding transcription factor activity;
TBX1	5	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; protein dimerization activity; DNA binding; sequence-specific DNA binding transcription factor activity;
RELA	5	positive regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; cytosol;

Genes shared at least 2 KEGG pathways with NPAS2 (count: 0)

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Region: chr2:101436613..101613291 View in gBrowse