ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HES6
Symbol Alias	bHLHb41
Approved Name	hairy and enhancer of split 6 (Drosophila)
Location	2q37.3
Position	chr2:239146908-239149303, -
External Links	HGNC: 18254 Entrez Gene: 55502 Ensembl: ENSG00000144485 UCSC: uc002vxz.2
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Brookes K, 2006	UNPHASED TDT P-value=0.0949, global P-value=0.228, WHAP TDT P_sum P-value=0.167, no SNP with nominal P-value<0.05 located in this gene	Non-significant

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs11689432	Chr1:11082610(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; missense_variant; upstream_gene_variant	1(1/0/0)

LD-proxies (count: 1)

rs_ID	Location	Functional Annotation
rs6744132	Chr2:239144542(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003677	DNA binding	Molecular Function		220
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function		132
GO:0003712	transcription cofactor activity	Molecular Function	ISS[10851137]	17
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process		42
GO:0006355	regulation of transcription, DNA-dependent	Biological Process		158
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0005667	transcription factor complex	Cellular Component	ISS[10851137]	51
GO:0046983	protein dimerization activity	Molecular Function		26
GO:0030154	cell differentiation	Biological Process		51
GO:0008134	transcription factor binding	Molecular Function	NAS[17611704]	38
GO:0007399	nervous system development	Biological Process		54

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with HES6 (count: 12)

Gene Symbol	Pathway Count	Pathway List
HMGA1	6	DNA binding; sequence-specific DNA binding transcription factor activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent; transcription factor complex; transcription factor binding;
E2F5	5	DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; transcription factor complex; transcription factor binding;
ETS1	5	DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; transcription factor complex; transcription factor binding;
FOXL1	5	DNA binding; sequence-specific DNA binding transcription factor activity; regulation of transcription, DNA-dependent; transcription factor complex; transcription factor binding;
MYT1L	5	DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; cell differentiation; nervous system development;
NEUROD6	5	DNA binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent; protein dimerization activity; cell differentiation;
NPAS2	5	DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; transcription factor complex; protein dimerization activity;
SREBF1	5	DNA binding; sequence-specific DNA binding transcription factor activity; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; protein dimerization activity;
TBX1	5	DNA binding; sequence-specific DNA binding transcription factor activity; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; protein dimerization activity;
CLOCK	5	sequence-specific DNA binding transcription factor activity; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription factor complex; protein dimerization activity;
KDM1A	5	sequence-specific DNA binding transcription factor activity; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; transcription factor complex; transcription factor binding;
POU2F3	5	sequence-specific DNA binding transcription factor activity; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; transcription factor complex; protein dimerization activity;

Genes shared at least 2 KEGG pathways with HES6 (count: 0)

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Region: chr2:239146908..239149303 View in gBrowse