ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HES6
Symbol Alias	bHLHb41
Approved Name	hes family bHLH transcription factor 6
Previous Name	"hairy and enhancer of split 6 (Drosophila)"
Location	2q37.3
Position	chr2:239146908-239149303, -1
External Links	HGNC: 18254 Entrez Gene: 55502 Ensembl: ENSG00000144485 UCSC: uc002vxz.3
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Brookes K, 2006	UNPHASED TDT P-value=0.0949, global P-value=0.228, WHAP TDT P_sum P-value=0.167, no SNP with nominal P-value<0.05 located in this gene	Non-significant

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 0)

LD-proxies (count: 1)

rs_ID	Location	Functional Annotation
rs6744132	chr2:239144542(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006355	regulation of transcription, DNA-dependent	biological process	NAS	182
GO:0006351	transcription, DNA-dependent	biological process	IEA	281
GO:0046983	protein dimerization activity	molecular function	IEA	28
GO:0003677	DNA binding	molecular function	IEA	257
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	148
GO:0005667	transcription factor complex	cellular component	ISS[10851137]	52
GO:0008134	transcription factor binding	molecular function	NAS[17611704]	44
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	IEA	46
GO:0003712	transcription cofactor activity	molecular function	ISS[10851137]	18
GO:0030154	cell differentiation	biological process	IEA	61
GO:0007399	nervous system development	biological process	IEA	60

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with HES6 (count: 11)

Gene Symbol	Pathway Count	Pathway List
HMGA1	6	regulation of transcription, DNA-dependent; transcription, DNA-dependent; DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription factor binding;
NEUROD6	5	regulation of transcription, DNA-dependent; transcription, DNA-dependent; protein dimerization activity; DNA binding; cell differentiation;
CLOCK	5	regulation of transcription, DNA-dependent; protein dimerization activity; sequence-specific DNA binding transcription factor activity; transcription factor complex; regulation of transcription from RNA polymerase II promoter;
FOXL1	5	regulation of transcription, DNA-dependent; DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription factor binding;
NPAS2	5	transcription, DNA-dependent; protein dimerization activity; DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex;
KDM1A	5	transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription factor binding; regulation of transcription from RNA polymerase II promoter;
SREBF1	5	transcription, DNA-dependent; protein dimerization activity; DNA binding; sequence-specific DNA binding transcription factor activity; regulation of transcription from RNA polymerase II promoter;
TBX1	5	transcription, DNA-dependent; protein dimerization activity; DNA binding; sequence-specific DNA binding transcription factor activity; regulation of transcription from RNA polymerase II promoter;
POU2F3	5	transcription, DNA-dependent; protein dimerization activity; sequence-specific DNA binding transcription factor activity; transcription factor complex; regulation of transcription from RNA polymerase II promoter;
MYT1L	5	transcription, DNA-dependent; DNA binding; sequence-specific DNA binding transcription factor activity; cell differentiation; nervous system development;
ETS1	5	transcription, DNA-dependent; DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription factor binding;

Genes shared at least 2 KEGG pathways with HES6 (count: 0)

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Region: chr2:239146908..239149303 View in gBrowse