ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0003700
Name sequence-specific DNA binding transcription factor activity
Type molecular function
No. of Genes in ADHDgene  148
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 148)

Literature-origin genes (count: 17)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
NR3C2 nuclear receptor subfamily 3, group C, member 2 4q31 1(0/1/0) IEA
TFEB transcription factor EB 6p21 1(0/0/1) IDA[19556463]; NAS[2115126]
MEIS2 Meis homeobox 2 15q14 1(0/0/1) IEA
MYT1L myelin transcription factor 1-like 2p25.3 1(0/0/1) IEA
HOXB1 homeobox B1 17q21.32 1(0/0/1) NAS
CREB5 cAMP responsive element binding protein 5 7p15 1(0/0/1) IDA[8378084]
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 12q23 2(2/0/0) IEA
HES6 hes family bHLH transcription factor 6 2q37.3 1(0/1/0) IEA
FOXP2 forkhead box P2 7q31 1(1/0/0) IDA[18987363]
NFIL3 nuclear factor, interleukin 3 regulated 9q22 2(1/1/0) TAS[7565758]
HES1 hes family bHLH transcription factor 1 3q28-q29 1(1/0/0) IDA[17681138]
CLOCK clock circadian regulator 4q12 2(2/0/0) ISS
ISL1 ISL LIM homeobox 1 5q11.2 1(0/1/0) IEA
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 6p12 1(1/0/0) IDA[12169688]
ETV5 ets variant 5 3q28 1(1/0/0) IDA[19443906]
LMO4 LIM domain only 4 1p22.3 1(0/1/0) TAS[10209267]
DMRT2 doublesex and mab-3 related transcription factor 2 9p24.3 1(0/0/1) TAS[10332030]

Genes from other sources Help (count: 131)

Approved Symbol Approved Name Source Evidence[PMID]
ZSCAN10 zinc finger and SCAN domain containing 10 Mapped by significant region ISS
IKZF1 IKAROS family zinc finger 1 (Ikaros) Mapped by LD-proxy IEA
HOXA4 homeobox A4 Mapped by significant region IEA
TCF25 transcription factor 25 (basic helix-loop-helix) Mapped by significant region IDA[16574069]
GATA6 GATA binding protein 6 Mapped by significant region IDA[19666519]
ZNF500 zinc finger protein 500 Mapped by significant region IEA
RORA RAR-related orphan receptor A Mapped by Literature SNP IDA[17545671]
PHF5A PHD finger protein 5A Mapped by PBA pathway ISS
HOXA3 homeobox A3 Mapped by significant region IEA
VENTX VENT homeobox Mapped by CNV IEA
EVX1 even-skipped homeobox 1 Mapped by significant region IEA
SPI1 spleen focus forming virus (SFFV) proviral integration oncogene Mapped by LD-proxy IDA[12833137]
IRX2 iroquois homeobox 2 Mapped by significant region IEA
HOXA10 homeobox A10 Mapped by significant region IEA
KMT2A lysine (K)-specific methyltransferase 2A Mapped by significant region NAS[10821850]
CREBZF CREB/ATF bZIP transcription factor Mapped by significant region IEA
BSX brain-specific homeobox Mapped by significant region IEA
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) Mapped by significant region TAS[8608938]
BARX1 BARX homeobox 1 Mapped by significant region NAS[10995576]
PHOX2A paired-like homeobox 2a Mapped by significant region IEA
AATF apoptosis antagonizing transcription factor Mapped by CNV IDA[10580117]
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A Mapped by significant region IDA[12048232]
HOXA1 homeobox A1 Mapped by significant region IEA
IRF9 interferon regulatory factor 9 Mapped by significant region IEA
ZNF131 zinc finger protein 131 Mapped by significant region NAS[7557990]
ZNF397 zinc finger protein 397 Mapped by significant region IEA
HOXA9 homeobox A9 Mapped by significant region IEA
MTA3 metastasis associated 1 family, member 3 Mapped by Literature SNP IEA
HOXA13 homeobox A13 Mapped by significant region IEA
TRIM29 tripartite motif containing 29 Mapped by significant region TAS[8188213]
HOXA6 homeobox A6 Mapped by significant region IEA
TBX1 T-box 1 Mapped by CNV IDA[11111039]
ATF6 activating transcription factor 6 Mapped by CNV IEA
MTA2 metastasis associated 1 family, member 2 Mapped by significant region IEA
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa Mapped by CNV IDA[9603525]
NPAT nuclear protein, ataxia-telangiectasia locus Mapped by CNV; Mapped by significant region IDA[18850719]
FOXD4 forkhead box D4 Mapped by CNV TAS[9325056]
ZNF202 zinc finger protein 202 Mapped by significant region IEA
PBX3 pre-B-cell leukemia homeobox 3 Mapped by significant region IEA
FOSL1 FOS-like antigen 1 Mapped by significant region IEA
E2F6 E2F transcription factor 6 Mapped by significant region IEA
ZNF287 zinc finger protein 287 Mapped by significant region IEA
ZNF24 zinc finger protein 24 Mapped by significant region IEA
ZNF483 zinc finger protein 483 Mapped by significant region IEA
RBPJ recombination signal binding protein for immunoglobulin kappa J region Mapped by CNV TAS[9874765]
HSF2 heat shock transcription factor 2 Mapped by significant region IEA
HOXA11 homeobox A11 Mapped by significant region IEA
PHF1 PHD finger protein 1 Mapped by LD-proxy TAS[9545646]
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 Mapped by significant region IDA[15485867]
NKX6-2 NK6 homeobox 2 Mapped by CNV NAS[11210186]
LMX1B LIM homeobox transcription factor 1, beta Mapped by significant region IDA[10767331]
RREB1 ras responsive element binding protein 1 Mapped by CNV IEA
HOXB3 homeobox B3 Mapped by LD-proxy IEA
TBX10 T-box 10 Mapped by significant region IEA
KLF11 Kruppel-like factor 11 Mapped by significant region TAS[9748269]
LHX2 LIM homeobox 2 Mapped by significant region IEA
FOXE1 forkhead box E1 (thyroid transcription factor 2) Mapped by significant region IDA[9697705]
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa Mapped by CNV NAS[9695952]
PRDM1 PR domain containing 1, with ZNF domain Mapped by CNV TAS[1851123]
IRX3 iroquois homeobox 3 Mapped by CNV IEA
BARX2 BARX homeobox 2 Mapped by significant region IEA
KDM1A lysine (K)-specific demethylase 1A Mapped by LD-proxy IEA
HOXA5 homeobox A5 Mapped by significant region IDA[10879542]
HMGA1 high mobility group AT-hook 1 Mapped by PBA pathway IMP[10428834]
ZNF213 zinc finger protein 213 Mapped by significant region IEA
ZFP37 ZFP37 zinc finger protein Mapped by significant region NAS[9585434]
HNF1B HNF1 homeobox B Mapped by CNV IDA[15509593]
NPAS2 neuronal PAS domain protein 2 Mapped by CNV IEA
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase Mapped by significant region TAS[2030914]
MKL2 MKL/myocardin-like 2 Mapped by significant region IEA
UBN1 ubinuclein 1 Mapped by significant region TAS[10725330]
ONECUT2 one cut homeobox 2 Mapped by significant region IEA
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa Mapped by significant region NAS[7801123]
HOXA7 homeobox A7 Mapped by significant region IEA
ZSCAN30 zinc finger and SCAN domain containing 30 Mapped by significant region IEA
IRX4 iroquois homeobox 4 Mapped by significant region IEA
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa Mapped by significant region IEA
IRX1 iroquois homeobox 1 Mapped by significant region IEA
KLF4 Kruppel-like factor 4 (gut) Mapped by significant region NAS[9422764]
SCAND3 SCAN domain containing 3 Mapped by LD-proxy IEA
SP4 Sp4 transcription factor Mapped by significant region IEA
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Mapped by significant region IEA
FOXL1 forkhead box L1 Mapped by significant region ISS
STRN3 striatin, calmodulin binding protein 3 Mapped by significant region IDA[11570823]
TADA2A transcriptional adaptor 2A Mapped by CNV TAS[8552087]
CREBBP CREB binding protein Mapped by significant region TAS[7913207]
HINFP histone H4 transcription factor Mapped by significant region IMP[9540062]
MYB v-myb avian myeloblastosis viral oncogene homolog Mapped by significant region IEA
ZNF396 zinc finger protein 396 Mapped by significant region IEA
FEV FEV (ETS oncogene family) Mapped by significant region IEA
MYRF myelin regulatory factor Mapped by LD-proxy; Mapped by significant region IEA
HOXA2 homeobox A2 Mapped by significant region IEA
NANOGP1 Nanog homeobox pseudogene 1 Mapped by CNV IEA
ZNF174 zinc finger protein 174 Mapped by significant region IDA[7673192]
RCOR2 REST corepressor 2 Mapped by significant region IEA
TSHZ2 teashirt zinc finger homeobox 2 Mapped by Literature SNP IEA
ZNF263 zinc finger protein 263 Mapped by LD-proxy; Mapped by significant region IEA
HIRA histone cell cycle regulator Mapped by CNV TAS[9731536]
CAPN15 calpain 15 Mapped by significant region TAS[9722942]
LHX1 LIM homeobox 1 Mapped by CNV IEA
ZSCAN29 zinc finger and SCAN domain containing 29 Mapped by LD-proxy IEA
SOX8 SRY (sex determining region Y)-box 8 Mapped by significant region IEA
ZNF70 zinc finger protein 70 Mapped by CNV NAS
GATAD2A GATA zinc finger domain containing 2A Mapped by LD-proxy IEA
POU2F3 POU class 2 homeobox 3 Mapped by significant region IEA
GSC2 goosecoid homeobox 2 Mapped by CNV IDA[9700206]
EBF1 early B-cell factor 1 Mapped by significant region IEA
ZNF367 zinc finger protein 367 Mapped by significant region IDA[15344908]
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 Mapped by significant region IDA[11909962]
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa Mapped by CNV NAS
SNAI3 snail family zinc finger 3 Mapped by significant region IEA
LZTR1 leucine-zipper-like transcription regulator 1 Mapped by CNV TAS[7633402]
TMEM229A transmembrane protein 229A Mapped by CNV IEA
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) Mapped by significant region IDA[9169153]
BATF2 basic leucine zipper transcription factor, ATF-like 2 Mapped by significant region IEA
RAX retina and anterior neural fold homeobox Mapped by LD-proxy; Mapped by significant region IEA
NEUROD2 neuronal differentiation 2 Mapped by LD-proxy TAS[8816493]
TRIM22 tripartite motif containing 22 Mapped by CNV TAS[7797467]
ZNF169 zinc finger protein 169 Mapped by significant region NAS
ZNF189 zinc finger protein 189 Mapped by significant region TAS[9653648]
SREBF1 sterol regulatory element binding transcription factor 1 Mapped by significant region IDA[16407292]
E4F1 E4F transcription factor 1 Mapped by significant region TAS[9121437]
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 Mapped by significant region IEA
PKNOX2 PBX/knotted 1 homeobox 2 Mapped by significant region IEA
ZNF215 zinc finger protein 215 Mapped by CNV NAS[10762538]
TBX6 T-box 6 Mapped by CNV IEA
NFE2L3 nuclear factor, erythroid 2-like 3 Mapped by CNV; Mapped by significant region IEA
FLI1 Fli-1 proto-oncogene, ETS transcription factor Mapped by significant region IEA
LHX6 LIM homeobox 6 Mapped by significant region NAS[10393337]
PTTG1 pituitary tumor-transforming 1 Mapped by significant region TAS[9811450]
ZEB2 zinc finger E-box binding homeobox 2 Mapped by PBA pathway IEA