ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NPAT
Symbol Alias	E14
Approved Name	nuclear protein, ataxia-telangiectasia locus
Location	11q22-q23
Position	chr11:108027942-108093369, -
External Links	HGNC: 7896 Entrez Gene: 4863 Ensembl: ENSG00000149308 UCSC: uc001pjz.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_143	chr11:107520009-107885084 (NCBI Build 35 (hg17))	365076	11q22.3	Duplication	Paternal

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)
11q22	chr11:97200000-110400000	1 (1/0/0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0010468	regulation of gene expression	Biological Process	IMP[15988025]	7
GO:0015030	Cajal body	Cellular Component	IDA[15988025]	11
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0008022	protein C-terminus binding	Molecular Function	IPI[15988025]	32
GO:0047485	protein N-terminus binding	Molecular Function	IPI[19170105]	23
GO:0044428	nuclear part	Cellular Component	IDA[19170105]	3
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[18850719]	80
GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	Biological Process	IMP[15988025]	7
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	IDA[18850719]	132
GO:0005515	protein binding	Molecular Function	IPI[18850719]	910
GO:0005634	nucleus	Cellular Component	IDA[15988025]	770
GO:0003713	transcription coactivator activity	Molecular Function	IDA[14585971]; IMP[15988025]	52
GO:0003714	transcription corepressor activity	Molecular Function	IMP[17163457]	29

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with NPAT (count: 17)

Gene Symbol	Pathway Count	Pathway List
HINFP	9	regulation of gene expression; Cajal body; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of transcription involved in G1/S phase of mitotic cell cycle; sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription coactivator activity;
NCOR1	6	transcription, DNA-dependent; nuclear part; sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription corepressor activity;
NRIP1	6	transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; protein binding; nucleus; transcription coactivator activity; transcription corepressor activity;
LHX1	5	regulation of gene expression; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; nucleus; transcription corepressor activity;
TRIM22	5	Cajal body; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; nucleus; transcription corepressor activity;
ATF6	5	transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription coactivator activity;
BIRC2	5	transcription, DNA-dependent; protein N-terminus binding; protein binding; nucleus; transcription coactivator activity;
ELK3	5	transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription corepressor activity;
ETS1	5	transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; protein binding; nucleus;
HIRA	5	transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription corepressor activity;
HMGA1	5	transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; protein binding; nucleus;
KAT5	5	transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; protein binding; nucleus; transcription coactivator activity;
MMS19	5	transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; protein binding; nucleus; transcription coactivator activity;
NCOR2	5	transcription, DNA-dependent; protein N-terminus binding; protein binding; nucleus; transcription corepressor activity;
SMARCD3	5	transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; protein binding; nucleus; transcription coactivator activity;
RELA	5	protein N-terminus binding; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; protein binding; nucleus;
SNW1	5	nuclear part; protein binding; nucleus; transcription coactivator activity; transcription corepressor activity;

Genes shared at least 2 KEGG pathways with NPAT (count: 0)

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Region: chr11:108027942..108093369 View in gBrowse