ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NRIP1
Symbol Alias	RIP140
Approved Name	nuclear receptor interacting protein 1
Name Alias	receptor interacting protein 140, "nuclear factor RIP140"
Location	21q11.2
Position	chr21:16333556-16437321, -
External Links	HGNC: 8001 Entrez Gene: 8204 Ensembl: ENSG00000180530 UCSC: uc002yjx.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035257	nuclear hormone receptor binding	Molecular Function	IPI[11518808]	30

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0042826	histone deacetylase binding	Molecular Function		10
GO:0035259	glucocorticoid receptor binding	Molecular Function	IPI[12773562]	2
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[10364267]	131
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	NAS[15572661]	80
GO:0050681	androgen receptor binding	Molecular Function	NAS[15572661]	10
GO:0046965	retinoid X receptor binding	Molecular Function		5
GO:0005515	protein binding	Molecular Function	IPI[19401155]	910
GO:0003714	transcription corepressor activity	Molecular Function	IDA[10364267]	29
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0005634	nucleus	Cellular Component	IDA[12773562]	770
GO:0030331	estrogen receptor binding	Molecular Function	IPI[7641693]	10
GO:0019915	lipid storage	Biological Process		4
GO:0030521	androgen receptor signaling pathway	Biological Process	NAS[15572661]	16
GO:0000118	histone deacetylase complex	Cellular Component		5
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[10364267]	78
GO:0001543	ovarian follicle rupture	Biological Process		1
GO:0003713	transcription coactivator activity	Molecular Function	IDA[11518808]; NAS[15572661]	52

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with NRIP1 (count: 45)

Gene Symbol	Pathway Count	Pathway List
KAT5	9	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; androgen receptor binding; protein binding; transcription, DNA-dependent; nucleus; androgen receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; transcription coactivator activity;
MED1	9	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein binding; nucleus; estrogen receptor binding; nuclear hormone receptor binding; androgen receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; transcription coactivator activity;
NSD1	9	positive regulation of transcription, DNA-dependent; androgen receptor binding; retinoid X receptor binding; transcription corepressor activity; transcription, DNA-dependent; nucleus; estrogen receptor binding; nuclear hormone receptor binding; negative regulation of transcription from RNA polymerase II promoter;
NCOR1	8	histone deacetylase binding; retinoid X receptor binding; protein binding; transcription corepressor activity; transcription, DNA-dependent; nucleus; histone deacetylase complex; negative regulation of transcription from RNA polymerase II promoter;
NCOA6	8	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; retinoid X receptor binding; protein binding; nucleus; estrogen receptor binding; nuclear hormone receptor binding; transcription coactivator activity;
SNW1	7	positive regulation of transcription from RNA polymerase II promoter; protein binding; transcription corepressor activity; nucleus; nuclear hormone receptor binding; negative regulation of transcription from RNA polymerase II promoter; transcription coactivator activity;
THRAP3	7	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein binding; nucleus; nuclear hormone receptor binding; androgen receptor signaling pathway; transcription coactivator activity;
MMS19	7	positive regulation of transcription, DNA-dependent; protein binding; transcription, DNA-dependent; nucleus; estrogen receptor binding; nuclear hormone receptor binding; transcription coactivator activity;
LPIN1	6	histone deacetylase binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleus; negative regulation of transcription from RNA polymerase II promoter; transcription coactivator activity;
NCOR2	6	histone deacetylase binding; protein binding; transcription corepressor activity; transcription, DNA-dependent; nucleus; negative regulation of transcription from RNA polymerase II promoter;
KDM1A	6	positive regulation of transcription from RNA polymerase II promoter; androgen receptor binding; protein binding; transcription, DNA-dependent; nucleus; negative regulation of transcription from RNA polymerase II promoter;
MED12	6	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; nucleus; nuclear hormone receptor binding; androgen receptor signaling pathway; transcription coactivator activity;
MED13	6	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; nucleus; nuclear hormone receptor binding; androgen receptor signaling pathway; transcription coactivator activity;
MED14	6	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; nucleus; nuclear hormone receptor binding; androgen receptor signaling pathway; transcription coactivator activity;
MED17	6	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; nucleus; nuclear hormone receptor binding; androgen receptor signaling pathway; transcription coactivator activity;
PRPF6	6	positive regulation of transcription from RNA polymerase II promoter; androgen receptor binding; protein binding; nucleus; nuclear hormone receptor binding; transcription coactivator activity;
TFAP2A	6	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; transcription coactivator activity;
HMGA1	6	positive regulation of transcription, DNA-dependent; retinoid X receptor binding; protein binding; transcription, DNA-dependent; nucleus; nuclear hormone receptor binding;
NPAT	6	positive regulation of transcription, DNA-dependent; protein binding; transcription corepressor activity; transcription, DNA-dependent; nucleus; transcription coactivator activity;
SMARCD3	6	positive regulation of transcription, DNA-dependent; protein binding; transcription, DNA-dependent; nucleus; nuclear hormone receptor binding; transcription coactivator activity;
TGFB1I1	6	positive regulation of transcription, DNA-dependent; androgen receptor binding; protein binding; nuclear hormone receptor binding; androgen receptor signaling pathway; transcription coactivator activity;
DAXX	6	androgen receptor binding; protein binding; transcription, DNA-dependent; nucleus; nuclear hormone receptor binding; androgen receptor signaling pathway;
HES1	5	histone deacetylase binding; positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter;
HEY2	5	histone deacetylase binding; positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter;
TCF21	5	histone deacetylase binding; positive regulation of transcription from RNA polymerase II promoter; androgen receptor binding; nucleus; negative regulation of transcription from RNA polymerase II promoter;
ETS1	5	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein binding; transcription, DNA-dependent; nucleus;
HNF1B	5	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter;
IRF7	5	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter;
MEIS2	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; transcription corepressor activity; nucleus; negative regulation of transcription from RNA polymerase II promoter;
MEN1	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; transcription, DNA-dependent; nucleus; negative regulation of transcription from RNA polymerase II promoter;
MTA2	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; histone deacetylase complex; negative regulation of transcription from RNA polymerase II promoter;
MYB	5	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein binding; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter;
NCOA7	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; transcription, DNA-dependent; nucleus; nuclear hormone receptor binding;
SMARCB1	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; transcription, DNA-dependent; nucleus; transcription coactivator activity;
SREBF1	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; transcription, DNA-dependent; nucleus; negative regulation of transcription from RNA polymerase II promoter;
UBE3A	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; androgen receptor signaling pathway; transcription coactivator activity;
UTF1	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; transcription, DNA-dependent; nucleus; transcription coactivator activity;
YAP1	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; transcription corepressor activity; nucleus; transcription coactivator activity;
HINFP	5	positive regulation of transcription, DNA-dependent; protein binding; transcription, DNA-dependent; nucleus; transcription coactivator activity;
MED16	5	positive regulation of transcription, DNA-dependent; nucleus; nuclear hormone receptor binding; androgen receptor signaling pathway; transcription coactivator activity;
MED30	5	positive regulation of transcription, DNA-dependent; protein binding; nucleus; nuclear hormone receptor binding; androgen receptor signaling pathway;
MED4	5	positive regulation of transcription, DNA-dependent; protein binding; nucleus; nuclear hormone receptor binding; androgen receptor signaling pathway;
RAN	5	positive regulation of transcription, DNA-dependent; androgen receptor binding; protein binding; androgen receptor signaling pathway; transcription coactivator activity;
SAP18	5	protein binding; transcription corepressor activity; transcription, DNA-dependent; nucleus; histone deacetylase complex;
DDX54	5	transcription corepressor activity; transcription, DNA-dependent; nucleus; estrogen receptor binding; nuclear hormone receptor binding;

Genes shared at least 2 KEGG pathways with NRIP1 (count: 0)

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Region: chr21:16333556..16437321 View in gBrowse