ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PRPF6
Previous Symbol	C20orf14
Symbol Alias	TOM, bB152O15.1, ANT-1, U5-102K, Prp6, hPrp6, SNRNP102, RP60
Approved Name	pre-mRNA processing factor 6
Previous Name	"chromosome 20 open reading frame 14", "PRP6 pre-mRNA processing factor 6 homolog (yeast)", "PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)"
Location	20q13.33
Position	chr20:62612488-62664453, 1
External Links	HGNC: 15860 Entrez Gene: 24148 Ensembl: ENSG00000101161 UCSC: uc002yho.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 21)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	cellular component	NAS[10788320]	43

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003723	RNA binding	molecular function	IDA	115
GO:0006403	RNA localization	biological process	IMP	1
GO:0008380	RNA splicing	biological process	NAS[10788320]; TAS	70
GO:0005634	nucleus	cellular component	IDA[16414017]	877
GO:0000398	mRNA splicing, via spliceosome	biological process	IC[15257298]; TAS	58
GO:0000245	spliceosomal complex assembly	biological process	NAS[10788320]	9
GO:0050681	androgen receptor binding	molecular function	IPI[16414017]	9
GO:0010467	gene expression	biological process	TAS	154
GO:0046540	U4/U6 x U5 tri-snRNP complex	cellular component	IDA[10788320]	3
GO:0005515	protein binding	molecular function	IPI[15840814]	1015
GO:0043021	ribonucleoprotein complex binding	molecular function	IDA[10788320]	4
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[16414017]	141
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0003713	transcription coactivator activity	molecular function	IGI[16414017]	58
GO:0071013	catalytic step 2 spliceosome	cellular component	IDA[11991638]	33
GO:0071001	U4/U6 snRNP	cellular component	IDA[10788320]	3
GO:0000244	assembly of spliceosomal tri-snRNP	biological process	IC[10788320]; IMP[15257298]	2
GO:0000375	RNA splicing, via transesterification reactions	biological process	NAS[10788320]	12
GO:0016607	nuclear speck	cellular component	IEA	40
GO:0005682	U5 snRNP	cellular component	IDA[10788320]	5

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PRPF6 (count: 76)

Gene Symbol	Pathway Count	Pathway List
CD2BP2	11	RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; U4/U6 x U5 tri-snRNP complex; protein binding; ribonucleoprotein complex binding; nucleoplasm; assembly of spliceosomal tri-snRNP; nuclear speck; U5 snRNP;
PRPF8	10	RNA binding; RNA splicing; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm; catalytic step 2 spliceosome; RNA splicing, via transesterification reactions; nuclear speck; U5 snRNP;
U2AF1	10	RNA binding; RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm; catalytic step 2 spliceosome; spliceosomal complex; nuclear speck;
SF3A3	10	RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm; catalytic step 2 spliceosome; spliceosomal complex; RNA splicing, via transesterification reactions; nuclear speck;
PRPF4	10	RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm; spliceosomal complex; U4/U6 snRNP; RNA splicing, via transesterification reactions; nuclear speck;
HNRNPA2B1	9	RNA binding; RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm; catalytic step 2 spliceosome; spliceosomal complex;
SNRPG	9	RNA binding; RNA splicing; mRNA splicing, via spliceosome; spliceosomal complex assembly; gene expression; protein binding; nucleoplasm; catalytic step 2 spliceosome; spliceosomal complex;
SNRPD1	9	RNA binding; RNA splicing; nucleus; mRNA splicing, via spliceosome; spliceosomal complex assembly; gene expression; protein binding; nucleoplasm; catalytic step 2 spliceosome;
SF3A1	9	RNA binding; RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm; catalytic step 2 spliceosome; spliceosomal complex;
DDX23	9	RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm; catalytic step 2 spliceosome; RNA splicing, via transesterification reactions; U5 snRNP;
SNRNP200	9	RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm; catalytic step 2 spliceosome; spliceosomal complex; U5 snRNP;
EFTUD2	9	RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm; catalytic step 2 spliceosome; spliceosomal complex; nuclear speck;
SNW1	9	nucleus; mRNA splicing, via spliceosome; gene expression; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity; catalytic step 2 spliceosome; spliceosomal complex;
HNRNPA1	8	RNA binding; RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; nucleoplasm; catalytic step 2 spliceosome; spliceosomal complex;
SF3B4	8	RNA binding; RNA splicing; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm; spliceosomal complex; RNA splicing, via transesterification reactions;
SNRPA1	8	RNA binding; RNA splicing; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm; catalytic step 2 spliceosome; spliceosomal complex;
HNRNPC	8	RNA binding; RNA splicing; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm; catalytic step 2 spliceosome; spliceosomal complex;
HNRNPH1	8	RNA binding; RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm; catalytic step 2 spliceosome;
RNPS1	8	RNA binding; RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm; nuclear speck;
SNRPD2	8	RNA splicing; mRNA splicing, via spliceosome; spliceosomal complex assembly; gene expression; protein binding; nucleoplasm; catalytic step 2 spliceosome; spliceosomal complex;
GEMIN2	8	RNA splicing; nucleus; spliceosomal complex assembly; gene expression; protein binding; nucleoplasm; spliceosomal complex; RNA splicing, via transesterification reactions;
TXNL4A	8	RNA splicing; mRNA splicing, via spliceosome; spliceosomal complex assembly; gene expression; protein binding; nucleoplasm; spliceosomal complex; RNA splicing, via transesterification reactions;
SMNDC1	7	RNA binding; RNA splicing; nucleus; protein binding; spliceosomal complex; RNA splicing, via transesterification reactions; nuclear speck;
U2AF2	7	RNA binding; RNA splicing; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm; spliceosomal complex;
SNRPA	7	RNA binding; RNA splicing; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm; spliceosomal complex;
FUS	7	RNA binding; RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm;
CPSF7	7	RNA binding; RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm;
NCBP1	7	RNA binding; RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm;
DHX8	7	RNA binding; RNA splicing; nucleus; mRNA splicing, via spliceosome; protein binding; catalytic step 2 spliceosome; spliceosomal complex;
SUGP1	7	RNA binding; RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; nucleoplasm; spliceosomal complex;
SNRPF	7	RNA binding; RNA splicing; mRNA splicing, via spliceosome; gene expression; nucleoplasm; catalytic step 2 spliceosome; spliceosomal complex;
SF3B2	7	RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; nucleoplasm; catalytic step 2 spliceosome; spliceosomal complex;
SNRPB	7	RNA splicing; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm; catalytic step 2 spliceosome; spliceosomal complex;
SF3B3	7	RNA splicing; mRNA splicing, via spliceosome; gene expression; nucleoplasm; catalytic step 2 spliceosome; spliceosomal complex; RNA splicing, via transesterification reactions;
SNRPB2	7	RNA splicing; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm; catalytic step 2 spliceosome; spliceosomal complex;
SNRPD3	7	RNA splicing; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm; catalytic step 2 spliceosome; spliceosomal complex;
MAML1	7	nucleus; gene expression; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity; nuclear speck;
PPIH	7	mRNA splicing, via spliceosome; U4/U6 x U5 tri-snRNP complex; protein binding; ribonucleoprotein complex binding; spliceosomal complex; U4/U6 snRNP; nuclear speck;
POLR2G	6	RNA binding; RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; nucleoplasm;
RBM4	6	RNA binding; RNA splicing; nucleus; protein binding; nucleoplasm; nuclear speck;
CPSF3	6	RNA binding; RNA splicing; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm;
CWC15	6	RNA binding; nucleus; mRNA splicing, via spliceosome; protein binding; catalytic step 2 spliceosome; spliceosomal complex;
DHX9	6	RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm;
SF3A2	6	RNA splicing; mRNA splicing, via spliceosome; gene expression; nucleoplasm; catalytic step 2 spliceosome; spliceosomal complex;
SMC1A	6	RNA splicing; nucleus; mRNA splicing, via spliceosome; gene expression; protein binding; nucleoplasm;
CDC40	6	RNA splicing; mRNA splicing, via spliceosome; gene expression; nucleoplasm; catalytic step 2 spliceosome; spliceosomal complex;
SLU7	6	nucleus; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; spliceosomal complex; RNA splicing, via transesterification reactions; nuclear speck;
YAP1	6	nucleus; gene expression; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity;
MAML2	6	nucleus; gene expression; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity; nuclear speck;
PRPF19	6	nucleus; mRNA splicing, via spliceosome; spliceosomal complex assembly; protein binding; catalytic step 2 spliceosome; nuclear speck;
MED1	6	nucleus; gene expression; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity;
NR5A1	6	nucleus; gene expression; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity;
SRRM2	5	RNA binding; nucleus; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; nuclear speck;
SF1	5	RNA binding; nucleus; mRNA splicing, via spliceosome; spliceosomal complex assembly; spliceosomal complex;
PHF5A	5	RNA splicing; mRNA splicing, via spliceosome; gene expression; nucleoplasm; nuclear speck;
HSPA8	5	RNA splicing; nucleus; gene expression; protein binding; spliceosomal complex;
THRAP3	5	RNA splicing; nucleus; protein binding; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity;
MED14	5	nucleus; gene expression; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity;
NRIP1	5	nucleus; androgen receptor binding; protein binding; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity;
TAF10	5	nucleus; gene expression; protein binding; nucleoplasm; transcription coactivator activity;
SART1	5	nucleus; mRNA splicing, via spliceosome; protein binding; nucleoplasm; catalytic step 2 spliceosome;
PSMC3	5	nucleus; gene expression; protein binding; nucleoplasm; transcription coactivator activity;
MED12	5	nucleus; gene expression; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity;
KDM1A	5	nucleus; androgen receptor binding; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm;
MEN1	5	nucleus; gene expression; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm;
MED13	5	nucleus; gene expression; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity;
MED17	5	nucleus; gene expression; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity;
NR4A2	5	nucleus; gene expression; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm;
SMARCB1	5	nucleus; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity;
KAT5	5	nucleus; androgen receptor binding; protein binding; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity;
MAPK3	5	nucleus; gene expression; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm;
ESRRA	5	nucleus; gene expression; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm;
NCOA6	5	nucleus; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity;
CREBBP	5	nucleus; gene expression; protein binding; nucleoplasm; transcription coactivator activity;
RBPJ	5	nucleus; gene expression; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm;
RAN	5	androgen receptor binding; gene expression; protein binding; nucleoplasm; transcription coactivator activity;

Genes shared at least 2 KEGG pathways with PRPF6 (count: 0)

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Region: chr20:62612488..62664453 View in gBrowse