ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	U2AF2
Symbol Alias	U2AF65
Approved Name	U2 small nuclear RNA auxiliary factor 2
Previous Name	U2 (RNU2) small nuclear RNA auxiliary factor 2
Name Alias	U2 small nuclear ribonucleoprotein auxiliary factor (65kD), "splicing factor U2AF 65 kD subunit", "U2 snRNP auxiliary factor large subunit"
Location	19q13.43
Position	chr19:56165416-56186082, +
External Links	HGNC: 23156 Entrez Gene: 11338 Ensembl: ENSG00000063244 UCSC: uc002qlu.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component	IDA[9731529]	51

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0070742	C2H2 zinc finger domain binding	Molecular Function		2
GO:0031124	mRNA 3'-end processing	Biological Process		8
GO:0048025	negative regulation of mRNA splicing, via spliceosome	Biological Process	IDA[15009664]	2
GO:0010467	gene expression	Biological Process		140
GO:0019899	enzyme binding	Molecular Function	IPI[19574390]	47
GO:0006406	mRNA export from nucleus	Biological Process		12
GO:0008380	RNA splicing	Biological Process		65
GO:0006369	termination of RNA polymerase II transcription	Biological Process		14
GO:0006397	mRNA processing	Biological Process	TAS[1538748]	50
GO:0006366	transcription from RNA polymerase II promoter	Biological Process		62
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005515	protein binding	Molecular Function		910
GO:0003723	RNA binding	Molecular Function		104
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IC[9731529]	54
GO:0000166	nucleotide binding	Molecular Function		73

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

Genes shared at least 5 GO terms with U2AF2 (count: 53)

Gene Symbol	Pathway Count	Pathway List
U2AF1	13	mRNA 3'-end processing; gene expression; mRNA export from nucleus; RNA splicing; termination of RNA polymerase II transcription; mRNA processing; transcription from RNA polymerase II promoter; spliceosomal complex; nucleoplasm; protein binding; RNA binding; mRNA splicing, via spliceosome; nucleotide binding;
CPSF3	11	mRNA 3'-end processing; gene expression; mRNA export from nucleus; RNA splicing; termination of RNA polymerase II transcription; mRNA processing; transcription from RNA polymerase II promoter; nucleoplasm; protein binding; RNA binding; mRNA splicing, via spliceosome;
CPSF7	11	mRNA 3'-end processing; gene expression; RNA splicing; termination of RNA polymerase II transcription; mRNA processing; transcription from RNA polymerase II promoter; nucleoplasm; protein binding; RNA binding; mRNA splicing, via spliceosome; nucleotide binding;
NCBP1	11	mRNA 3'-end processing; gene expression; mRNA export from nucleus; RNA splicing; termination of RNA polymerase II transcription; mRNA processing; transcription from RNA polymerase II promoter; nucleoplasm; protein binding; RNA binding; mRNA splicing, via spliceosome;
HNRNPA2B1	10	negative regulation of mRNA splicing, via spliceosome; gene expression; RNA splicing; mRNA processing; spliceosomal complex; nucleoplasm; protein binding; RNA binding; mRNA splicing, via spliceosome; nucleotide binding;
SNRPD3	10	gene expression; enzyme binding; RNA splicing; termination of RNA polymerase II transcription; mRNA processing; transcription from RNA polymerase II promoter; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SNRPG	10	gene expression; RNA splicing; termination of RNA polymerase II transcription; mRNA processing; transcription from RNA polymerase II promoter; spliceosomal complex; nucleoplasm; protein binding; RNA binding; mRNA splicing, via spliceosome;
CDC40	9	mRNA 3'-end processing; gene expression; mRNA export from nucleus; RNA splicing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome;
SF3B4	9	gene expression; RNA splicing; mRNA processing; spliceosomal complex; nucleoplasm; protein binding; RNA binding; mRNA splicing, via spliceosome; nucleotide binding;
SNRPB	9	gene expression; RNA splicing; termination of RNA polymerase II transcription; mRNA processing; transcription from RNA polymerase II promoter; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SNRPF	9	gene expression; RNA splicing; termination of RNA polymerase II transcription; mRNA processing; transcription from RNA polymerase II promoter; spliceosomal complex; nucleoplasm; RNA binding; mRNA splicing, via spliceosome;
CLP1	8	mRNA 3'-end processing; gene expression; RNA splicing; termination of RNA polymerase II transcription; mRNA processing; transcription from RNA polymerase II promoter; nucleoplasm; mRNA splicing, via spliceosome;
PCF11	8	mRNA 3'-end processing; gene expression; RNA splicing; termination of RNA polymerase II transcription; mRNA processing; transcription from RNA polymerase II promoter; nucleoplasm; mRNA splicing, via spliceosome;
HNRNPA1	8	gene expression; RNA splicing; mRNA processing; spliceosomal complex; nucleoplasm; RNA binding; mRNA splicing, via spliceosome; nucleotide binding;
HNRNPC	8	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; protein binding; RNA binding; mRNA splicing, via spliceosome; nucleotide binding;
PRPF8	8	gene expression; RNA splicing; mRNA processing; spliceosomal complex; nucleoplasm; protein binding; RNA binding; mRNA splicing, via spliceosome;
SF3A1	8	gene expression; RNA splicing; mRNA processing; spliceosomal complex; nucleoplasm; protein binding; RNA binding; mRNA splicing, via spliceosome;
SNRPA	8	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; protein binding; RNA binding; mRNA splicing, via spliceosome; nucleotide binding;
SNRPB2	8	gene expression; RNA splicing; mRNA processing; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome; nucleotide binding;
EFTUD2	7	gene expression; RNA splicing; mRNA processing; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
FUS	7	gene expression; RNA splicing; nucleoplasm; protein binding; RNA binding; mRNA splicing, via spliceosome; nucleotide binding;
HNRNPH1	7	gene expression; RNA splicing; nucleoplasm; protein binding; RNA binding; mRNA splicing, via spliceosome; nucleotide binding;
PRPF6	7	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; protein binding; RNA binding; mRNA splicing, via spliceosome;
SF3A3	7	gene expression; RNA splicing; mRNA processing; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SNRPA1	7	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; protein binding; RNA binding; mRNA splicing, via spliceosome;
DDX23	6	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
LSM11	6	gene expression; termination of RNA polymerase II transcription; mRNA processing; transcription from RNA polymerase II promoter; nucleoplasm; protein binding;
LSM4	6	gene expression; RNA splicing; mRNA processing; spliceosomal complex; protein binding; RNA binding;
POLR2G	6	gene expression; RNA splicing; transcription from RNA polymerase II promoter; nucleoplasm; RNA binding; mRNA splicing, via spliceosome;
PRPF4	6	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SF3A2	6	gene expression; RNA splicing; mRNA processing; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome;
SF3B2	6	gene expression; RNA splicing; mRNA processing; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome;
SF3B3	6	gene expression; RNA splicing; mRNA processing; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome;
SNRNP200	6	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SNRPD1	6	gene expression; RNA splicing; nucleoplasm; protein binding; RNA binding; mRNA splicing, via spliceosome;
SNRPD2	6	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
TXNL4A	6	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
RBM4	6	RNA splicing; mRNA processing; nucleoplasm; protein binding; RNA binding; nucleotide binding;
TARDBP	6	RNA splicing; mRNA processing; transcription from RNA polymerase II promoter; protein binding; RNA binding; nucleotide binding;
ZCRB1	6	RNA splicing; mRNA processing; spliceosomal complex; nucleoplasm; RNA binding; nucleotide binding;
CD2BP2	5	gene expression; RNA splicing; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
DHX9	5	gene expression; RNA splicing; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
HSPA8	5	gene expression; RNA splicing; mRNA processing; spliceosomal complex; protein binding;
NXF1	5	gene expression; mRNA export from nucleus; nucleoplasm; protein binding; nucleotide binding;
PHF5A	5	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome;
SMC1A	5	gene expression; RNA splicing; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SNW1	5	gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
TAF10	5	gene expression; enzyme binding; transcription from RNA polymerase II promoter; nucleoplasm; protein binding;
DHX8	5	RNA splicing; spliceosomal complex; protein binding; RNA binding; mRNA splicing, via spliceosome;
RBFOX1	5	RNA splicing; mRNA processing; protein binding; RNA binding; nucleotide binding;
SCAF8	5	RNA splicing; mRNA processing; spliceosomal complex; RNA binding; nucleotide binding;
SMNDC1	5	RNA splicing; mRNA processing; spliceosomal complex; protein binding; RNA binding;
ZRSR2	5	RNA splicing; spliceosomal complex; protein binding; mRNA splicing, via spliceosome; nucleotide binding;

Genes shared at least 2 KEGG pathways with U2AF2 (count: 0)

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Region: chr19:56165416..56186082 View in gBrowse