ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RBM4
Symbol Alias	LARK, RBM4A, ZCRB3A, ZCCHC21
Approved Name	RNA binding motif protein 4
Location	11q13
Position	chr11:66406088-66434153, +
External Links	HGNC: 9901 Entrez Gene: 5936 Ensembl: ENSG00000173933
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 32)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 32)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051403	stress-activated MAPK cascade	Biological Process	IDA[17284590]	10
GO:0051149	positive regulation of muscle cell differentiation	Biological Process		5
GO:0046822	regulation of nucleocytoplasmic transport	Biological Process	IDA[12628928]	1
GO:0045947	negative regulation of translational initiation	Biological Process	IDA[19801630]	1
GO:0097167	circadian regulation of translation	Biological Process		1
GO:0097158	pre-mRNA intronic pyrimidine-rich binding	Molecular Function	IDA[16260624]	1
GO:0097157	pre-mRNA intronic binding	Molecular Function	IDA[16260624]	2
GO:0032055	negative regulation of translation in response to stress	Biological Process	IDA[17284590]	1
GO:0030154	cell differentiation	Biological Process		51
GO:0017148	negative regulation of translation	Biological Process	IDA[17284590]	5
GO:0016607	nuclear speck	Cellular Component	IDA[12628928]	34
GO:0043153	entrainment of circadian clock by photoperiod	Biological Process		2
GO:0035278	negative regulation of translation involved in gene silencing by miRNA	Biological Process	IDA[19801630]	1
GO:0035198	miRNA binding	Molecular Function	IDA[19801630]	1
GO:0033554	cellular response to stress	Biological Process	IDA[17284590]	12
GO:0005737	cytoplasm	Cellular Component	IDA[12628928]	690
GO:0006396	RNA processing	Biological Process	TAS[9169144]	11
GO:0005654	nucleoplasm	Cellular Component	IDA[12628928]	183
GO:0005730	nucleolus	Cellular Component	IDA[12628928]	243
GO:0008380	RNA splicing	Biological Process		65
GO:0010494	cytoplasmic stress granule	Cellular Component	IDA[17284590]	4
GO:0006397	mRNA processing	Biological Process		50
GO:0008270	zinc ion binding	Molecular Function		323
GO:0002192	IRES-dependent translational initiation	Biological Process	IDA[17284590]	1
GO:0003723	RNA binding	Molecular Function	IDA[19561594]	104
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	Biological Process	IDA[12628928]	4
GO:0002190	cap-independent translational initiation	Biological Process	IDA[17284590]	1
GO:0005515	protein binding	Molecular Function	IPI[16934801]	910
GO:0005634	nucleus	Cellular Component	IDA[17284590]	770
GO:0003729	mRNA binding	Molecular Function		10
GO:0003730	mRNA 3'-UTR binding	Molecular Function		7
GO:0000166	nucleotide binding	Molecular Function		73

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with RBM4 (count: 88)

Gene Symbol	Pathway Count	Pathway List
HNRNPA2B1	10	pre-mRNA intronic binding; cytoplasm; nucleoplasm; nucleolus; RNA splicing; mRNA processing; RNA binding; protein binding; nucleus; nucleotide binding;
U2AF1	10	nuclear speck; nucleoplasm; nucleolus; RNA splicing; mRNA processing; zinc ion binding; RNA binding; protein binding; nucleus; nucleotide binding;
FUS	9	cytoplasm; nucleoplasm; nucleolus; RNA splicing; zinc ion binding; RNA binding; protein binding; nucleus; nucleotide binding;
HNRNPH1	9	cytoplasm; RNA processing; nucleoplasm; nucleolus; RNA splicing; RNA binding; protein binding; nucleus; nucleotide binding;
EFTUD2	8	nuclear speck; cytoplasm; nucleoplasm; nucleolus; RNA splicing; mRNA processing; protein binding; nucleus;
SF3A3	8	nuclear speck; nucleoplasm; nucleolus; RNA splicing; mRNA processing; zinc ion binding; protein binding; nucleus;
HNRNPA1	8	cytoplasm; nucleoplasm; nucleolus; RNA splicing; mRNA processing; RNA binding; nucleus; nucleotide binding;
TARDBP	8	nucleolus; RNA splicing; mRNA processing; RNA binding; protein binding; nucleus; mRNA 3'-UTR binding; nucleotide binding;
IGF2BP3	7	negative regulation of translation; cytoplasm; RNA binding; protein binding; nucleus; mRNA 3'-UTR binding; nucleotide binding;
NSRP1	7	nuclear speck; RNA splicing; mRNA processing; regulation of alternative mRNA splicing, via spliceosome; protein binding; nucleus; mRNA binding;
PRPF4	7	nuclear speck; RNA processing; nucleoplasm; nucleolus; RNA splicing; protein binding; nucleus;
PSPC1	7	nuclear speck; cytoplasm; nucleolus; RNA binding; protein binding; nucleus; nucleotide binding;
RFWD2	7	nuclear speck; cytoplasm; nucleoplasm; nucleolus; zinc ion binding; protein binding; nucleus;
SMNDC1	7	nuclear speck; cytoplasm; RNA splicing; mRNA processing; RNA binding; protein binding; nucleus;
RBM4B	7	entrainment of circadian clock by photoperiod; nucleolus; RNA splicing; mRNA processing; zinc ion binding; RNA binding; nucleotide binding;
CELF1	7	cytoplasm; mRNA processing; RNA binding; protein binding; nucleus; mRNA binding; nucleotide binding;
RBFOX1	7	cytoplasm; RNA splicing; mRNA processing; RNA binding; protein binding; nucleus; nucleotide binding;
CPSF7	7	nucleoplasm; RNA splicing; mRNA processing; RNA binding; protein binding; nucleus; nucleotide binding;
SF3A1	7	nucleoplasm; nucleolus; RNA splicing; mRNA processing; RNA binding; protein binding; nucleus;
MAPK1	6	stress-activated MAPK cascade; cytoplasm; nucleoplasm; nucleolus; protein binding; nucleus;
CD2BP2	6	nuclear speck; cytoplasm; nucleoplasm; RNA splicing; protein binding; nucleus;
CDK12	6	nuclear speck; nucleolus; RNA splicing; mRNA processing; protein binding; nucleus;
PRPF6	6	nuclear speck; nucleoplasm; RNA splicing; RNA binding; protein binding; nucleus;
PRPF8	6	nuclear speck; nucleoplasm; RNA splicing; mRNA processing; RNA binding; protein binding;
RCHY1	6	nuclear speck; cytoplasm; nucleolus; zinc ion binding; protein binding; nucleus;
SETD1A	6	nuclear speck; nucleolus; RNA binding; protein binding; nucleus; nucleotide binding;
SLU7	6	nuclear speck; cellular response to stress; cytoplasm; nucleolus; zinc ion binding; nucleus;
TUT1	6	nuclear speck; nucleolus; zinc ion binding; RNA binding; protein binding; mRNA 3'-UTR binding;
NR4A2	6	cellular response to stress; cytoplasm; nucleoplasm; zinc ion binding; protein binding; nucleus;
ATXN1	6	cytoplasm; RNA processing; nucleoplasm; nucleolus; protein binding; nucleus;
ATXN2	6	cytoplasm; nucleolus; cytoplasmic stress granule; RNA binding; protein binding; nucleus;
CELF4	6	cytoplasm; nucleolus; regulation of alternative mRNA splicing, via spliceosome; nucleus; mRNA binding; nucleotide binding;
DHX9	6	cytoplasm; nucleoplasm; nucleolus; RNA splicing; protein binding; nucleus;
LARP7	6	cytoplasm; RNA processing; nucleoplasm; RNA binding; nucleus; nucleotide binding;
NOL8	6	cytoplasm; nucleolus; RNA binding; protein binding; nucleus; nucleotide binding;
PGR	6	cytoplasm; nucleoplasm; nucleolus; zinc ion binding; protein binding; nucleus;
SMC1A	6	cytoplasm; nucleoplasm; nucleolus; RNA splicing; protein binding; nucleus;
ZFR	6	cytoplasm; nucleolus; zinc ion binding; RNA binding; protein binding; nucleus;
ZMAT5	6	cytoplasm; nucleolus; RNA splicing; mRNA processing; zinc ion binding; nucleus;
DHX8	6	RNA processing; nucleolus; RNA splicing; RNA binding; protein binding; nucleus;
NCBP1	6	nucleoplasm; RNA splicing; mRNA processing; RNA binding; protein binding; nucleus;
SF3B4	6	nucleoplasm; RNA splicing; mRNA processing; RNA binding; protein binding; nucleotide binding;
U2AF2	6	nucleoplasm; RNA splicing; mRNA processing; RNA binding; protein binding; nucleotide binding;
ZCRB1	6	nucleoplasm; RNA splicing; mRNA processing; zinc ion binding; RNA binding; nucleotide binding;
SCAF8	6	nucleolus; RNA splicing; mRNA processing; RNA binding; nucleus; nucleotide binding;
THRAP3	6	nucleolus; RNA splicing; mRNA processing; regulation of alternative mRNA splicing, via spliceosome; protein binding; nucleus;
MAPK3	5	stress-activated MAPK cascade; nucleoplasm; nucleolus; protein binding; nucleus;
MAPK7	5	stress-activated MAPK cascade; cell differentiation; nucleoplasm; protein binding; nucleus;
NR5A1	5	cell differentiation; nucleoplasm; zinc ion binding; protein binding; nucleus;
SMARCB1	5	cell differentiation; nucleoplasm; nucleolus; protein binding; nucleus;
MAML1	5	nuclear speck; nucleoplasm; nucleolus; protein binding; nucleus;
NXF1	5	nuclear speck; nucleoplasm; protein binding; mRNA binding; nucleotide binding;
EGLN3	5	cellular response to stress; cytoplasm; nucleoplasm; protein binding; nucleus;
ALKBH8	5	cytoplasm; nucleolus; RNA binding; protein binding; nucleus;
BARD1	5	cytoplasm; zinc ion binding; RNA binding; protein binding; nucleus;
CHD1L	5	cytoplasm; nucleolus; protein binding; nucleus; nucleotide binding;
DGCR8	5	cytoplasm; nucleoplasm; nucleolus; protein binding; nucleus;
IGHMBP2	5	cytoplasm; zinc ion binding; RNA binding; protein binding; nucleus;
MEN1	5	cytoplasm; nucleoplasm; nucleolus; protein binding; nucleus;
MPHOSPH6	5	cytoplasm; nucleolus; RNA binding; protein binding; nucleus;
NUMA1	5	cytoplasm; nucleoplasm; nucleolus; protein binding; nucleus;
PDCD4	5	cytoplasm; nucleolus; RNA binding; protein binding; nucleus;
RAD23B	5	cytoplasm; nucleoplasm; nucleolus; protein binding; nucleus;
RAD9A	5	cytoplasm; nucleoplasm; nucleolus; protein binding; nucleus;
RBPJ	5	cytoplasm; nucleoplasm; nucleolus; protein binding; nucleus;
RCC1	5	cytoplasm; nucleoplasm; nucleolus; protein binding; nucleus;
RNF40	5	cytoplasm; nucleolus; zinc ion binding; protein binding; nucleus;
SART1	5	cytoplasm; nucleoplasm; nucleolus; protein binding; nucleus;
SSRP1	5	cytoplasm; nucleoplasm; nucleolus; protein binding; nucleus;
TRIM32	5	cytoplasm; zinc ion binding; RNA binding; protein binding; nucleus;
TRIM5	5	cytoplasm; nucleolus; zinc ion binding; protein binding; nucleus;
XPO1	5	cytoplasm; nucleoplasm; nucleolus; RNA binding; protein binding;
XRCC5	5	cytoplasm; nucleoplasm; nucleolus; protein binding; nucleus;
NOVA1	5	RNA processing; RNA splicing; RNA binding; nucleus; mRNA binding;
CPSF3	5	nucleoplasm; RNA splicing; mRNA processing; RNA binding; protein binding;
DDX23	5	nucleoplasm; nucleolus; RNA splicing; protein binding; nucleus;
HINFP	5	nucleoplasm; nucleolus; zinc ion binding; protein binding; nucleus;
HNRNPC	5	nucleoplasm; RNA splicing; RNA binding; protein binding; nucleotide binding;
SF3B2	5	nucleoplasm; nucleolus; RNA splicing; mRNA processing; nucleus;
SNRNP200	5	nucleoplasm; nucleolus; RNA splicing; protein binding; nucleus;
SNRPA	5	nucleoplasm; RNA splicing; RNA binding; protein binding; nucleotide binding;
SNRPB2	5	nucleoplasm; RNA splicing; mRNA processing; protein binding; nucleotide binding;
SNRPD1	5	nucleoplasm; RNA splicing; RNA binding; protein binding; nucleus;
SNRPG	5	nucleoplasm; RNA splicing; mRNA processing; RNA binding; protein binding;
HSPA8	5	nucleolus; RNA splicing; mRNA processing; protein binding; nucleus;
RBM14	5	nucleolus; RNA binding; protein binding; nucleus; nucleotide binding;
SNRNP35	5	RNA splicing; mRNA processing; RNA binding; nucleus; nucleotide binding;
SRSF8	5	RNA splicing; mRNA processing; RNA binding; nucleus; nucleotide binding;

Genes shared at least 2 KEGG pathways with RBM4 (count: 0)

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Region: chr11:66406088..66434153 View in gBrowse