ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CPSF3
Symbol Alias	CPSF-73, CPSF73, YSH1
Approved Name	cleavage and polyadenylation specific factor 3, 73kDa
Previous Name	"cleavage and polyadenylation specific factor 3, 73kD subunit"
Location	2p25.1
Position	chr2:9563697-9613230, 1
External Links	HGNC: 2326 Entrez Gene: 51692 Ensembl: ENSG00000119203 UCSC: uc002qzo.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2p25.1	chr2:7100000-12200000	2 (1/0/1)

Gene related GO terms (count: 19)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	cellular component	IDA[18305108]	2
GO:0006397	mRNA processing	biological process	TAS	53
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0003723	RNA binding	molecular function	ISS	115
GO:0005515	protein binding	molecular function	IPI[18288197]	1015
GO:0010467	gene expression	biological process	TAS	154
GO:0030529	ribonucleoprotein complex	cellular component	IEA	24
GO:0006406	mRNA export from nucleus	biological process	TAS	15
GO:0004521	endoribonuclease activity	molecular function	ISS	2
GO:0031124	mRNA 3'-end processing	biological process	TAS	9
GO:0046872	metal ion binding	molecular function	IEA	200
GO:0006366	transcription from RNA polymerase II promoter	biological process	TAS	63
GO:0006398	histone mRNA 3'-end processing	biological process	IDA[18688255]	2
GO:0008409	5'-3' exonuclease activity	molecular function	ISS	3
GO:0000398	mRNA splicing, via spliceosome	biological process	TAS	58
GO:0006369	termination of RNA polymerase II transcription	biological process	TAS	15
GO:0006379	mRNA cleavage	biological process	TAS[8929409]	4
GO:0006378	mRNA polyadenylation	biological process	TAS[8929409]	2
GO:0008380	RNA splicing	biological process	TAS	70

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with CPSF3 (count: 47)

Gene Symbol	Pathway Count	Pathway List
NCBP1	13	mRNA processing; nucleoplasm; RNA binding; protein binding; gene expression; ribonucleoprotein complex; mRNA export from nucleus; mRNA 3'-end processing; transcription from RNA polymerase II promoter; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA cleavage; RNA splicing;
U2AF1	11	mRNA processing; nucleoplasm; RNA binding; protein binding; gene expression; mRNA export from nucleus; mRNA 3'-end processing; transcription from RNA polymerase II promoter; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; RNA splicing;
U2AF2	11	mRNA processing; nucleoplasm; RNA binding; protein binding; gene expression; mRNA export from nucleus; mRNA 3'-end processing; transcription from RNA polymerase II promoter; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; RNA splicing;
CPSF7	10	mRNA processing; nucleoplasm; RNA binding; protein binding; gene expression; mRNA 3'-end processing; transcription from RNA polymerase II promoter; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; RNA splicing;
RNPS1	10	nucleoplasm; RNA binding; protein binding; gene expression; mRNA export from nucleus; mRNA 3'-end processing; transcription from RNA polymerase II promoter; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; RNA splicing;
PCF11	9	mRNA processing; nucleoplasm; gene expression; mRNA 3'-end processing; transcription from RNA polymerase II promoter; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA cleavage; RNA splicing;
SNRPG	9	mRNA processing; nucleoplasm; RNA binding; protein binding; gene expression; transcription from RNA polymerase II promoter; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; RNA splicing;
SNRPF	8	mRNA processing; nucleoplasm; RNA binding; gene expression; transcription from RNA polymerase II promoter; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; RNA splicing;
SNRPB	8	mRNA processing; nucleoplasm; protein binding; gene expression; transcription from RNA polymerase II promoter; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; RNA splicing;
HNRNPA2B1	8	mRNA processing; nucleoplasm; RNA binding; protein binding; gene expression; ribonucleoprotein complex; mRNA splicing, via spliceosome; RNA splicing;
SNRPD3	8	mRNA processing; nucleoplasm; protein binding; gene expression; transcription from RNA polymerase II promoter; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; RNA splicing;
CLP1	8	mRNA processing; nucleoplasm; gene expression; mRNA 3'-end processing; transcription from RNA polymerase II promoter; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; RNA splicing;
CDC40	8	nucleoplasm; gene expression; mRNA export from nucleus; mRNA 3'-end processing; transcription from RNA polymerase II promoter; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; RNA splicing;
PRPF8	7	mRNA processing; nucleoplasm; RNA binding; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
HNRNPA1	7	mRNA processing; nucleoplasm; RNA binding; gene expression; ribonucleoprotein complex; mRNA splicing, via spliceosome; RNA splicing;
LSM11	7	mRNA processing; nucleoplasm; protein binding; gene expression; transcription from RNA polymerase II promoter; histone mRNA 3'-end processing; termination of RNA polymerase II transcription;
SF3B4	7	mRNA processing; nucleoplasm; RNA binding; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
SF3A1	7	mRNA processing; nucleoplasm; RNA binding; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
EFTUD2	6	mRNA processing; nucleoplasm; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
SF3A3	6	mRNA processing; nucleoplasm; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
SNRPB2	6	mRNA processing; nucleoplasm; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
HNRNPH1	6	nucleoplasm; RNA binding; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
HNRNPC	6	nucleoplasm; RNA binding; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
POLR2G	6	nucleoplasm; RNA binding; gene expression; transcription from RNA polymerase II promoter; mRNA splicing, via spliceosome; RNA splicing;
SNRPA	6	nucleoplasm; RNA binding; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
SNRPD1	6	nucleoplasm; RNA binding; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
SNRPA1	6	nucleoplasm; RNA binding; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
DHX9	6	nucleoplasm; protein binding; gene expression; ribonucleoprotein complex; mRNA splicing, via spliceosome; RNA splicing;
FUS	6	nucleoplasm; RNA binding; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
PRPF6	6	nucleoplasm; RNA binding; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
TUT1	5	mRNA cleavage and polyadenylation specificity factor complex; RNA binding; protein binding; mRNA cleavage; mRNA polyadenylation;
SF3B2	5	mRNA processing; nucleoplasm; gene expression; mRNA splicing, via spliceosome; RNA splicing;
HSPA8	5	mRNA processing; protein binding; gene expression; ribonucleoprotein complex; RNA splicing;
GEMIN2	5	mRNA processing; nucleoplasm; protein binding; gene expression; RNA splicing;
LSM4	5	mRNA processing; RNA binding; protein binding; gene expression; RNA splicing;
SF3B3	5	mRNA processing; nucleoplasm; gene expression; mRNA splicing, via spliceosome; RNA splicing;
SF3A2	5	mRNA processing; nucleoplasm; gene expression; mRNA splicing, via spliceosome; RNA splicing;
RBM4	5	mRNA processing; nucleoplasm; RNA binding; protein binding; RNA splicing;
SNRNP200	5	nucleoplasm; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
XPO1	5	nucleoplasm; RNA binding; protein binding; gene expression; ribonucleoprotein complex;
TXNL4A	5	nucleoplasm; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
CD2BP2	5	nucleoplasm; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
SUGP1	5	nucleoplasm; RNA binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
SNRPD2	5	nucleoplasm; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
PRPF4	5	nucleoplasm; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
DDX23	5	nucleoplasm; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;
SMC1A	5	nucleoplasm; protein binding; gene expression; mRNA splicing, via spliceosome; RNA splicing;

Genes shared at least 2 KEGG pathways with CPSF3 (count: 0)

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Region: chr2:9563697..9613230 View in gBrowse