ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CPSF3
Symbol Alias	CPSF-73, CPSF73, YSH1
Approved Name	cleavage and polyadenylation specific factor 3, 73kDa
Previous Name	cleavage and polyadenylation specific factor 3, 73kD subunit
Location	2p25.1
Position	chr2:9563697-9613230, +
External Links	HGNC: 2326 Entrez Gene: 51692 Ensembl: ENSG00000119203 UCSC: uc002qzo.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2p25.1	chr2:7100000-12200000	2 (1/0/1)

Gene related GO terms (count: 19)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0046872	metal ion binding	Molecular Function		170
GO:0030529	ribonucleoprotein complex	Cellular Component		23
GO:0031124	mRNA 3'-end processing	Biological Process		8
GO:0008409	5'-3' exonuclease activity	Molecular Function		3
GO:0010467	gene expression	Biological Process		140
GO:0000398	mRNA splicing, via spliceosome	Biological Process		54
GO:0003723	RNA binding	Molecular Function		104
GO:0004521	endoribonuclease activity	Molecular Function		2
GO:0005515	protein binding	Molecular Function	IPI[18288197]	910
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	Cellular Component	IDA[18305108]	2
GO:0006366	transcription from RNA polymerase II promoter	Biological Process		62
GO:0006369	termination of RNA polymerase II transcription	Biological Process		14
GO:0006378	mRNA polyadenylation	Biological Process	TAS[8929409]	2
GO:0006379	mRNA cleavage	Biological Process	TAS[8929409]	4
GO:0006397	mRNA processing	Biological Process		50
GO:0006398	histone mRNA 3'-end processing	Biological Process	IDA[18688255]	2
GO:0006406	mRNA export from nucleus	Biological Process		12
GO:0008380	RNA splicing	Biological Process		65

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03015	mRNA surveillance pathway	17	The mRNA surveillance pathway is a quality control mechanism...... The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins. More...

Genes shared at least 5 GO terms with CPSF3 (count: 45)

Gene Symbol	Pathway Count	Pathway List
NCBP1	13	ribonucleoprotein complex; mRNA 3'-end processing; gene expression; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA cleavage; mRNA processing; mRNA export from nucleus; RNA splicing;
U2AF1	11	mRNA 3'-end processing; gene expression; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; mRNA export from nucleus; RNA splicing;
U2AF2	11	mRNA 3'-end processing; gene expression; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; mRNA export from nucleus; RNA splicing;
CPSF7	10	mRNA 3'-end processing; gene expression; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; RNA splicing;
PCF11	9	mRNA 3'-end processing; gene expression; mRNA splicing, via spliceosome; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA cleavage; mRNA processing; RNA splicing;
SNRPG	9	gene expression; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; RNA splicing;
HNRNPA2B1	8	ribonucleoprotein complex; gene expression; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; mRNA processing; RNA splicing;
CDC40	8	mRNA 3'-end processing; gene expression; mRNA splicing, via spliceosome; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA export from nucleus; RNA splicing;
CLP1	8	mRNA 3'-end processing; gene expression; mRNA splicing, via spliceosome; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; RNA splicing;
SNRPB	8	gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; RNA splicing;
SNRPD3	8	gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; RNA splicing;
SNRPF	8	gene expression; mRNA splicing, via spliceosome; RNA binding; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; RNA splicing;
HNRNPA1	7	ribonucleoprotein complex; gene expression; mRNA splicing, via spliceosome; RNA binding; nucleoplasm; mRNA processing; RNA splicing;
LSM11	7	gene expression; protein binding; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; histone mRNA 3'-end processing;
PRPF8	7	gene expression; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; mRNA processing; RNA splicing;
SF3A1	7	gene expression; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; mRNA processing; RNA splicing;
SF3B4	7	gene expression; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; mRNA processing; RNA splicing;
DHX9	6	ribonucleoprotein complex; gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm; RNA splicing;
EFTUD2	6	gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm; mRNA processing; RNA splicing;
FUS	6	gene expression; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing;
HNRNPC	6	gene expression; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing;
HNRNPH1	6	gene expression; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing;
POLR2G	6	gene expression; mRNA splicing, via spliceosome; RNA binding; nucleoplasm; transcription from RNA polymerase II promoter; RNA splicing;
PRPF6	6	gene expression; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing;
SF3A3	6	gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm; mRNA processing; RNA splicing;
SNRPA	6	gene expression; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing;
SNRPA1	6	gene expression; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing;
SNRPB2	6	gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm; mRNA processing; RNA splicing;
SNRPD1	6	gene expression; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing;
HSPA8	5	ribonucleoprotein complex; gene expression; protein binding; mRNA processing; RNA splicing;
XPO1	5	ribonucleoprotein complex; gene expression; RNA binding; protein binding; nucleoplasm;
CD2BP2	5	gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm; RNA splicing;
DDX23	5	gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm; RNA splicing;
LSM4	5	gene expression; RNA binding; protein binding; mRNA processing; RNA splicing;
PRPF4	5	gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm; RNA splicing;
SF3A2	5	gene expression; mRNA splicing, via spliceosome; nucleoplasm; mRNA processing; RNA splicing;
SF3B2	5	gene expression; mRNA splicing, via spliceosome; nucleoplasm; mRNA processing; RNA splicing;
SF3B3	5	gene expression; mRNA splicing, via spliceosome; nucleoplasm; mRNA processing; RNA splicing;
SMC1A	5	gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm; RNA splicing;
SNRNP200	5	gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm; RNA splicing;
SNRPD2	5	gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm; RNA splicing;
TXNL4A	5	gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm; RNA splicing;
RBM4	5	RNA binding; protein binding; nucleoplasm; mRNA processing; RNA splicing;
TARDBP	5	RNA binding; protein binding; transcription from RNA polymerase II promoter; mRNA processing; RNA splicing;
TUT1	5	RNA binding; protein binding; mRNA cleavage and polyadenylation specificity factor complex; mRNA polyadenylation; mRNA cleavage;

Genes shared at least 2 KEGG pathways with CPSF3 (count: 0)

View in gBrowse

Region: chr2:9563697..9613230 View in gBrowse