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KEGG Pathway Report
Basic Info
| ID | hsa03015 |
|---|---|
| Name | mRNA surveillance pathway |
| Description | The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins. |
| No. of Genes in ADHDgene | 17 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 17)
Literature-origin genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | 4p16.1 | 1(1/0/0) |
Genes from other sources (count: 16)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| CPSF7 | cleavage and polyadenylation specific factor 7, 59kDa | 11q12.2 | Mapped by significant region |
| SMG1 | smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) | 16p12.3 | Mapped by significant region |
| PELO | pelota homolog (Drosophila) | 5q11.2 | Mapped by LD-proxy; Mapped by literature SNP |
| CPSF3 | cleavage and polyadenylation specific factor 3, 73kDa | 2p25.1 | Mapped by significant region |
| SMG7 | smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) | 1q25 | Mapped by significant region |
| SAP18 | Sin3A-associated protein, 18kDa | 13q12.11 | Mapped by significant region |
| CLP1 | CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae) | 11q12 | Mapped by significant region |
| NCBP1 | nuclear cap binding protein subunit 1, 80kDa | 9q34.1 | Mapped by significant region |
| PPP2R5B | protein phosphatase 2, regulatory subunit B', beta | 11q12 | Mapped by significant region |
| PCF11 | PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae) | 11q13 | Mapped by significant region |
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | 11q23.1 | Mapped by significant region |
| HBS1L | HBS1-like (S. cerevisiae) | 6q23.3 | Mapped by significant region |
| CSTF2T | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant | 10q11 | Mapped by CNV |
| NXF1 | nuclear RNA export factor 1 | 11q12-q13 | Mapped by significant region |
| PABPN1L | poly(A) binding protein, nuclear 1-like (cytoplasmic) | 16q24.3 | Mapped by significant region |
| PPP2R2D | protein phosphatase 2, regulatory subunit B, delta | 10q26.3 | Mapped by CNV |