Gene Report
Basic Info
| Approved Symbol |
NXF1
|
| Symbol Alias |
TAP, Mex67, DKFZp667O0311 |
| Approved Name |
nuclear RNA export factor 1 |
| Name Alias |
tip associating protein |
| Location |
11q12-q13 |
| Position |
chr11:62559598-62573774, - |
| External Links |
HGNC: 8071
Entrez Gene: 10482
Ensembl: ENSG00000162231
UCSC: uc001nvf.1
|
| No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
| Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 13)
Gene related KEGG pathways (count: 3)
| ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
| hsa03015 |
mRNA surveillance pathway |
17 |
The mRNA surveillance pathway is a quality control mechanism......
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
More...
|
| hsa03008 |
Ribosome biogenesis in eukaryotes |
12 |
Ribosomes are the cellular factories responsible for making ......
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
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|
| hsa03013 |
RNA transport |
15 |
RNA transport from the nucleus to the cytoplasm is fundamen......
RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs, are transported by specific export receptors, which belong to the karyopherin-beta family proteins. A feature of karyopherins is their regulation by the small GTPase Ran. However, general mRNA export is mechanistically different. Nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3'-end formation and even translation.
More...
|
Genes shared at least 5 GO terms with NXF1 (count: 11)
Genes shared at least 2 KEGG pathways with NXF1 (count: 7)
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