ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NMD3
Symbol Alias	CGI-07
Approved Name	NMD3 homolog (S. cerevisiae)
Location	3q26.1
Position	chr3:160822484-160971320, +
External Links	HGNC: 24250 Entrez Gene: 51068 Ensembl: ENSG00000169251 UCSC: uc003feb.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_38	chr3:162419058-163993833 (NCBI Build 36.1 (hg18))	1574775	3q26.1	Loss

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 5)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 5)

ID	Name	Type	No. of Genes in ADHDgene
GO:0005654	nucleoplasm	Cellular Component	183
GO:0005730	nucleolus	Cellular Component	243
GO:0005737	cytoplasm	Cellular Component	690
GO:0015031	protein transport	Biological Process	75
GO:0005634	nucleus	Cellular Component	770

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03008	Ribosome biogenesis in eukaryotes	12	Ribosomes are the cellular factories responsible for making ...... Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage. More...
hsa03013	RNA transport	15	RNA transport from the nucleus to the cytoplasm is fundamen...... RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs, are transported by specific export receptors, which belong to the karyopherin-beta family proteins. A feature of karyopherins is their regulation by the small GTPase Ran. However, general mRNA export is mechanistically different. Nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3'-end formation and even translation. More...

Genes shared at least 5 GO terms with NMD3 (count: 0)

Genes shared at least 2 KEGG pathways with NMD3 (count: 5)

Gene Symbol	Pathway Count	Pathway List
C9orf23	2	Ribosome biogenesis in eukaryotes; RNA transport;
NXF1	2	Ribosome biogenesis in eukaryotes; RNA transport;
RAN	2	Ribosome biogenesis in eukaryotes; RNA transport;
RPP30	2	Ribosome biogenesis in eukaryotes; RNA transport;
XPO1	2	Ribosome biogenesis in eukaryotes; RNA transport;

View in gBrowse

Region: chr3:160822484..160971320 View in gBrowse