ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0005654
Name nucleoplasm
Type cellular component
No. of Genes in ADHDgene  210
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 210)

Literature-origin genes (count: 16)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 11p11.2 1(0/0/1) TAS
TLE4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 9q21.32 1(1/0/0) TAS
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 9q21.32 1(1/0/0) TAS
ATXN1 ataxin 1 6p23 1(0/0/1) IDA[12757932]
MED27 mediator complex subunit 27 9q34.13 1(0/1/0) TAS
NR3C2 nuclear receptor subfamily 3, group C, member 2 4q31 1(0/1/0) TAS
DUSP1 dual specificity phosphatase 1 5q35.1 1(0/1/0) IBA
GEMIN2 gem (nuclear organelle) associated protein 2 14q21.1 1(1/0/0) TAS
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 8q13.3 1(0/0/1) TAS
LARP7 La ribonucleoprotein domain family, member 7 4q25 1(1/0/0) IEA
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 7q35-q36 1(0/0/1) TAS
MAP2K3 mitogen-activated protein kinase kinase 3 17q11.2 1(0/1/0) TAS
NR4A2 nuclear receptor subfamily 4, group A, member 2 2q22-q23 2(0/2/0) TAS
XPO1 exportin 1 2p15 1(0/0/1) TAS
DSCC1 DNA replication and sister chromatid cohesion 1 8q24.12 1(0/1/0) IDA[16682347]
FANCL Fanconi anemia, complementation group L 2p16.1 1(0/1/0) TAS

Genes from other sources Help (count: 194)

Approved Symbol Approved Name Source Evidence[PMID]
CENPP centromere protein P Mapped by significant region TAS
IRF7 interferon regulatory factor 7 Mapped by LD-proxy TAS
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa Mapped by PBA pathway TAS
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 Mapped by significant region TAS
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A Mapped by significant region TAS
NCBP1 nuclear cap binding protein subunit 1, 80kDa Mapped by significant region TAS
NR6A1 nuclear receptor subfamily 6, group A, member 1 Mapped by significant region TAS
NCOR2 nuclear receptor corepressor 2 Mapped by CNV TAS
RNPS1 RNA binding protein S1, serine-rich domain Mapped by significant region TAS
SNRPA1 small nuclear ribonucleoprotein polypeptide A' Mapped by PBA pathway TAS
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa Mapped by significant region TAS
TXN thioredoxin Mapped by significant region TAS
HEMGN hemogen Mapped by significant region IEA
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa Mapped by CNV TAS
DHFRP1 dihydrofolate reductase pseudogene 1 Mapped by significant region TAS
CDC45 cell division cycle 45 Mapped by CNV TAS
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 Mapped by CNV IDA[15840814]; TAS
MED13 mediator complex subunit 13 Mapped by PBA pathway TAS
PALB2 partner and localizer of BRCA2 Mapped by significant region TAS
TERF2IP telomeric repeat binding factor 2, interacting protein Mapped by significant region TAS
MED4 mediator complex subunit 4 Mapped by PBA pathway TAS
DUSP2 dual specificity phosphatase 2 Mapped by LD-proxy IBA
ANAPC4 anaphase promoting complex subunit 4 Mapped by CNV TAS
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 Mapped by significant region TAS
CDC40 cell division cycle 40 Mapped by PBA pathway TAS
SNRPA small nuclear ribonucleoprotein polypeptide A Mapped by PBA pathway TAS
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) Mapped by CNV TAS
CREBBP CREB binding protein Mapped by significant region TAS
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa Mapped by significant region TAS
MED24 mediator complex subunit 24 Mapped by PBA pathway TAS
DGCR8 DGCR8 microprocessor complex subunit Mapped by CNV TAS
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) Mapped by CNV; Mapped by significant region TAS
RCC1 regulator of chromosome condensation 1 Mapped by PBA pathway TAS
SNW1 SNW domain containing 1 Mapped by PBA pathway TAS
RNF169 ring finger protein 169 Mapped by significant region IDA
ZFPM1 zinc finger protein, FOG family member 1 Mapped by significant region TAS
IRF9 interferon regulatory factor 9 Mapped by significant region TAS
XPA xeroderma pigmentosum, complementation group A Mapped by significant region TAS
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 Mapped by CNV ISS
PRM1 protamine 1 Mapped by significant region TAS[2081589]
MAPK9 mitogen-activated protein kinase 9 Mapped by CNV TAS
FUS fused in sarcoma Mapped by CNV TAS
SNRPF small nuclear ribonucleoprotein polypeptide F Mapped by PBA pathway TAS
PRPF8 pre-mRNA processing factor 8 Mapped by PBA pathway TAS
BANF1 barrier to autointegration factor 1 Mapped by significant region TAS
MAPK7 mitogen-activated protein kinase 7 Mapped by significant region TAS
SF3A2 splicing factor 3a, subunit 2, 66kDa Mapped by PBA pathway TAS
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa Mapped by significant region TAS
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa Mapped by significant region TAS
CLP1 cleavage and polyadenylation factor I subunit 1 Mapped by significant region TAS
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) Mapped by significant region TAS
PRM2 protamine 2 Mapped by significant region TAS[2081589]
PRPF6 pre-mRNA processing factor 6 Mapped by PBA pathway TAS
FANCA Fanconi anemia, complementation group A Mapped by significant region TAS
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 Mapped by significant region TAS
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa Mapped by CNV TAS
UBB ubiquitin B Mapped by significant region TAS
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) Mapped by significant region TAS
CHEK1 checkpoint kinase 1 Mapped by significant region TAS
PHF5A PHD finger protein 5A Mapped by PBA pathway TAS
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) Mapped by significant region TAS
KPNA5 karyopherin alpha 5 (importin alpha 6) Mapped by CNV; Mapped by significant region TAS
NMD3 NMD3 ribosome export adaptor Mapped by CNV IEA
H2AFX H2A histone family, member X Mapped by significant region TAS
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 Mapped by significant region TAS
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Mapped by PBA pathway TAS
NPAP1 nuclear pore associated protein 1 Mapped by CNV; Mapped by significant region IEA
SNRPB2 small nuclear ribonucleoprotein polypeptide B Mapped by PBA pathway TAS
KIF23 kinesin family member 23 Mapped by PBA pathway TAS
SF3A3 splicing factor 3a, subunit 3, 60kDa Mapped by PBA pathway TAS
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa Mapped by CNV TAS
TP53BP1 tumor protein p53 binding protein 1 Mapped by Literature SNP TAS
HINFP histone H4 transcription factor Mapped by significant region IDA[11553631]
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase Mapped by significant region TAS
CDC25B cell division cycle 25B Mapped by CNV TAS
CIRBP cold inducible RNA binding protein Mapped by CNV IEA
MED30 mediator complex subunit 30 Mapped by PBA pathway TAS
USP28 ubiquitin specific peptidase 28 Mapped by significant region IDA[17558397]
GTF3A general transcription factor IIIA Mapped by LD-proxy TAS
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 Mapped by CNV; Mapped by significant region; Mapped by PBA pathway TAS
UBC ubiquitin C Mapped by CNV TAS
SQSTM1 sequestosome 1 Mapped by CNV TAS
POLA2 polymerase (DNA directed), alpha 2, accessory subunit Mapped by significant region TAS
U2AF1 U2 small nuclear RNA auxiliary factor 1 Mapped by PBA pathway TAS
CENPN centromere protein N Mapped by significant region TAS
RBM4 RNA binding motif protein 4 Mapped by significant region IDA[12628928]
E4F1 E4F transcription factor 1 Mapped by significant region IEA
PDPK1 3-phosphoinositide dependent protein kinase-1 Mapped by significant region TAS
MED7 mediator complex subunit 7 Mapped by significant region TAS
YAP1 Yes-associated protein 1 Mapped by significant region TAS
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 Mapped by significant region TAS
ERCC8 excision repair cross-complementing rodent repair deficiency, complementation group 8 Mapped by CNV TAS
NXF1 nuclear RNA export factor 1 Mapped by significant region TAS
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 Mapped by PBA pathway IDA[8521471]; TAS
MAPK3 mitogen-activated protein kinase 3 Mapped by CNV TAS
NR5A1 nuclear receptor subfamily 5, group A, member 1 Mapped by significant region TAS
RSF1 remodeling and spacing factor 1 Mapped by significant region TAS
U2AF2 U2 small nuclear RNA auxiliary factor 2 Mapped by PBA pathway TAS
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa Mapped by CNV; Mapped by significant region TAS
CDC26 cell division cycle 26 Mapped by significant region TAS
EGLN3 egl-9 family hypoxia-inducible factor 3 Mapped by Literature SNP TAS
NUMA1 nuclear mitotic apparatus protein 1 Mapped by significant region TAS
PGR progesterone receptor Mapped by significant region TAS
FEN1 flap structure-specific endonuclease 1 Mapped by Literature SNP; Mapped by significant region TAS
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 Mapped by PBA pathway IEA
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Mapped by CNV TAS[7801128]
LSM11 LSM11, U7 small nuclear RNA associated Mapped by significant region TAS
TRIP12 thyroid hormone receptor interactor 12 Mapped by PBA pathway IDA
SF3B2 splicing factor 3b, subunit 2, 145kDa Mapped by significant region; Mapped by PBA pathway TAS
POLD4 polymerase (DNA-directed), delta 4, accessory subunit Mapped by significant region TAS
ERCC4 excision repair cross-complementing rodent repair deficiency, complementation group 4 Mapped by significant region TAS
MED23 mediator complex subunit 23 Mapped by significant region TAS
NCOA6 nuclear receptor coactivator 6 Mapped by PBA pathway TAS
CDC14B cell division cycle 14B Mapped by significant region IDA[18662541]
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) Mapped by PBA pathway TAS
ATF6 activating transcription factor 6 Mapped by CNV TAS
JMJD1C jumonji domain containing 1C Mapped by PBA pathway TAS
SUGP1 SURP and G patch domain containing 1 Mapped by LD-proxy TAS
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) Mapped by CNV; Mapped by significant region TAS
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 Mapped by PBA pathway TAS
SF3A1 splicing factor 3a, subunit 1, 120kDa Mapped by PBA pathway TAS
MED17 mediator complex subunit 17 Mapped by significant region; Mapped by PBA pathway TAS
RAD23B RAD23 homolog B (S. cerevisiae) Mapped by significant region TAS
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase Mapped by significant region TAS
MAU2 MAU2 sister chromatid cohesion factor Mapped by LD-proxy IDA[16682347]
GRHL1 grainyhead-like 1 (Drosophila) Mapped by significant region TAS
POLR1A polymerase (RNA) I polypeptide A, 194kDa Mapped by CNV TAS
SMC1A structural maintenance of chromosomes 1A Mapped by PBA pathway TAS
KDM1A lysine (K)-specific demethylase 1A Mapped by LD-proxy TAS
PCF11 PCF11 cleavage and polyadenylation factor subunit Mapped by significant region TAS
SART1 squamous cell carcinoma antigen recognized by T cells Mapped by significant region IDA[16687569]
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa Mapped by CNV; Mapped by PBA pathway TAS
RPS2 ribosomal protein S2 Mapped by significant region IDA[16263090]
POLD3 polymerase (DNA-directed), delta 3, accessory subunit Mapped by significant region TAS
MAML2 mastermind-like 2 (Drosophila) Mapped by significant region TAS
PRDM9 PR domain containing 9 Mapped by significant region TAS
PRPF4 pre-mRNA processing factor 4 Mapped by significant region TAS
HMGA1 high mobility group AT-hook 1 Mapped by PBA pathway TAS
MED14 mediator complex subunit 14 Mapped by PBA pathway TAS
SF3B4 splicing factor 3b, subunit 4, 49kDa Mapped by PBA pathway TAS
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit Mapped by CNV TAS
MAML1 mastermind-like 1 (Drosophila) Mapped by CNV TAS
SMC3 structural maintenance of chromosomes 3 Mapped by PBA pathway TAS
ATM ataxia telangiectasia mutated Mapped by CNV; Mapped by significant region TAS
KDM2A lysine (K)-specific demethylase 2A Mapped by significant region IEA
RAD1 RAD1 homolog (S. pombe) Mapped by significant region TAS
DDB1 damage-specific DNA binding protein 1, 127kDa Mapped by significant region TAS
MPG N-methylpurine-DNA glycosylase Mapped by significant region TAS
ESRRA estrogen-related receptor alpha Mapped by significant region TAS
EFTUD2 elongation factor Tu GTP binding domain containing 2 Mapped by PBA pathway TAS
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 Mapped by significant region TAS
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) Mapped by LD-proxy IEA
RRM2 ribonucleotide reductase M2 Mapped by significant region TAS
CAMK2D calcium/calmodulin-dependent protein kinase II delta Mapped by CNV TAS
SF3B3 splicing factor 3b, subunit 3, 130kDa Mapped by PBA pathway TAS
DROSHA drosha, ribonuclease type III Mapped by significant region TAS
SSRP1 structure specific recognition protein 1 Mapped by significant region TAS
POLR2G polymerase (RNA) II (DNA directed) polypeptide G Mapped by significant region TAS
NTHL1 nth endonuclease III-like 1 (E. coli) Mapped by significant region TAS
MEN1 multiple endocrine neoplasia I Mapped by significant region TAS
NCL nucleolin Mapped by Literature SNP IEA
TERT telomerase reverse transcriptase Mapped by significant region IDA[19567472]; TAS
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) Mapped by CNV IEA
RBPJ recombination signal binding protein for immunoglobulin kappa J region Mapped by CNV TAS
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 Mapped by significant region TAS
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) Mapped by significant region TAS
CCND1 cyclin D1 Mapped by significant region TAS
RAN RAN, member RAS oncogene family Mapped by PBA pathway TAS
GATA6 GATA binding protein 6 Mapped by significant region TAS
STRN3 striatin, calmodulin binding protein 3 Mapped by significant region IDA[11570823]
MED1 mediator complex subunit 1 Mapped by LD-proxy; Mapped by PBA pathway TAS
RAD9A RAD9 homolog A (S. pombe) Mapped by significant region TAS
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa Mapped by significant region TAS
MED12 mediator complex subunit 12 Mapped by PBA pathway TAS
FANCC Fanconi anemia, complementation group C Mapped by significant region TAS
TXNL4A thioredoxin-like 4A Mapped by PBA pathway TAS
GINS2 GINS complex subunit 2 (Psf2 homolog) Mapped by significant region TAS
MED15 mediator complex subunit 15 Mapped by CNV TAS
MED16 mediator complex subunit 16 Mapped by PBA pathway TAS
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 Mapped by PBA pathway TAS
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 Mapped by significant region IEA
CIITA class II, major histocompatibility complex, transactivator Mapped by significant region TAS
CDT1 chromatin licensing and DNA replication factor 1 Mapped by significant region TAS
MAPK1 mitogen-activated protein kinase 1 Mapped by LD-proxy TAS
MUSTN1 musculoskeletal, embryonic nuclear protein 1 Mapped by LD-proxy IEA
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) Mapped by LD-proxy TAS
SNRPG small nuclear ribonucleoprotein polypeptide G Mapped by PBA pathway TAS
PLK1 polo-like kinase 1 Mapped by significant region TAS
RORA RAR-related orphan receptor A Mapped by Literature SNP TAS
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) Mapped by significant region TAS
MED20 mediator complex subunit 20 Mapped by CNV TAS
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa Mapped by significant region TAS
MED10 mediator complex subunit 10 Mapped by significant region TAS
NRBP1 nuclear receptor binding protein 1 Mapped by PBA pathway TAS