ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	POLA2
Symbol Alias	FLJ21662
Approved Name	polymerase (DNA directed), alpha 2 (70kD subunit)
Location	11q13
Position	chr11:65029233-65073060, +
External Links	HGNC: 30073 Entrez Gene: 23649 Ensembl: ENSG00000014138 UCSC: uc001odj.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000084	S phase of mitotic cell cycle	Biological Process		20
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process		26
GO:0000060	protein import into nucleus, translocation	Biological Process		5
GO:0046982	protein heterodimerization activity	Molecular Function		68
GO:0005730	nucleolus	Cellular Component		243
GO:0005737	cytoplasm	Cellular Component		690
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005658	alpha DNA polymerase:primase complex	Cellular Component		1
GO:0006271	DNA strand elongation involved in DNA replication	Biological Process		6
GO:0032201	telomere maintenance via semi-conservative replication	Biological Process		5
GO:0006260	DNA replication	Biological Process	NAS[8223465]	27
GO:0006270	DNA replication initiation	Biological Process		3
GO:0000722	telomere maintenance via recombination	Biological Process		6
GO:0000723	telomere maintenance	Biological Process		10
GO:0000216	M/G1 transition of mitotic cell cycle	Biological Process		13
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0003887	DNA-directed DNA polymerase activity	Molecular Function		5
GO:0005634	nucleus	Cellular Component		770
GO:0003674	molecular_function	Molecular Function		126
GO:0003677	DNA binding	Molecular Function		220

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00230	Purine metabolism	22
hsa01100	Metabolic pathways	237
hsa03030	DNA replication	7	A complex network of interacting proteins and enzymes is req...... A complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (DnaB or MCM complex) precedes the DNA synthetic machinery and unwinds the duplex parental DNA in cooperation with the SSB or RPA. On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, DNA replication occurs discontinuously by synthesis and joining of short Okazaki fragments. In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). The DNA primase (DnaG) is needed to form RNA primers. Normally, during replication of the lagging-strand DNA template, an RNA primer is removed either by an RNase H or by the 5 to 3 exonuclease activity of DNA pol I, and the DNA ligase joins the Okazaki fragments. In eukaryotes, three DNA polymerases (alpha, delta, and epsilon) have been identified. DNA primase forms a permanent complex with DNA polymerase alpha. PCNA and RFC function as a clamp and a clamp loader. FEN 1 and RNase H1 remove the RNA from the Okazaki fragments and DNA ligase I joins the DNA. More...
hsa00240	Pyrimidine metabolism	13

Genes shared at least 5 GO terms with POLA2 (count: 35)

Gene Symbol	Pathway Count	Pathway List
POLE	13	S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; telomere maintenance via semi-conservative replication; DNA replication; DNA replication initiation; telomere maintenance via recombination; telomere maintenance; M/G1 transition of mitotic cell cycle; mitotic cell cycle; DNA-directed DNA polymerase activity; nucleus; DNA binding;
FEN1	11	S phase of mitotic cell cycle; nucleolus; nucleoplasm; DNA strand elongation involved in DNA replication; telomere maintenance via semi-conservative replication; DNA replication; telomere maintenance via recombination; telomere maintenance; mitotic cell cycle; nucleus; DNA binding;
CDC45	10	S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; cytoplasm; nucleoplasm; DNA strand elongation involved in DNA replication; DNA replication; DNA replication initiation; M/G1 transition of mitotic cell cycle; mitotic cell cycle; nucleus;
POLD3	10	S phase of mitotic cell cycle; nucleolus; nucleoplasm; DNA strand elongation involved in DNA replication; telomere maintenance via semi-conservative replication; telomere maintenance via recombination; telomere maintenance; mitotic cell cycle; DNA-directed DNA polymerase activity; nucleus;
POLD4	10	S phase of mitotic cell cycle; nucleoplasm; DNA strand elongation involved in DNA replication; telomere maintenance via semi-conservative replication; DNA replication; telomere maintenance via recombination; telomere maintenance; mitotic cell cycle; DNA-directed DNA polymerase activity; nucleus;
CDT1	8	S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; DNA replication; M/G1 transition of mitotic cell cycle; mitotic cell cycle; nucleus; DNA binding;
PSMC3	7	S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; cytoplasm; nucleoplasm; M/G1 transition of mitotic cell cycle; mitotic cell cycle; nucleus;
PSME1	6	S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; cytoplasm; nucleoplasm; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
SMC1A	6	protein heterodimerization activity; nucleolus; cytoplasm; nucleoplasm; mitotic cell cycle; nucleus;
TAF4B	6	protein heterodimerization activity; nucleolus; cytoplasm; nucleoplasm; nucleus; DNA binding;
SSRP1	6	nucleolus; cytoplasm; nucleoplasm; DNA replication; nucleus; DNA binding;
XRCC5	6	nucleolus; cytoplasm; nucleoplasm; telomere maintenance; nucleus; DNA binding;
CCND1	5	S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; mitotic cell cycle; nucleus;
PSMB7	5	S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
PSMD5	5	S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
PSMD7	5	S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
PSME2	5	S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
UBB	5	S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
UBC	5	S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
HINFP	5	G1/S transition of mitotic cell cycle; nucleolus; nucleoplasm; nucleus; DNA binding;
RCC1	5	G1/S transition of mitotic cell cycle; nucleolus; cytoplasm; nucleoplasm; nucleus;
RRM2	5	G1/S transition of mitotic cell cycle; cytoplasm; nucleoplasm; DNA replication; mitotic cell cycle;
CEP57	5	protein import into nucleus, translocation; nucleolus; cytoplasm; mitotic cell cycle; nucleus;
SMC3	5	protein heterodimerization activity; cytoplasm; nucleoplasm; mitotic cell cycle; nucleus;
TAF13	5	protein heterodimerization activity; nucleolus; nucleoplasm; nucleus; DNA binding;
ATXN1	5	nucleolus; cytoplasm; nucleoplasm; nucleus; DNA binding;
DHX9	5	nucleolus; cytoplasm; nucleoplasm; nucleus; DNA binding;
FUS	5	nucleolus; cytoplasm; nucleoplasm; nucleus; DNA binding;
MAPK1	5	nucleolus; cytoplasm; nucleoplasm; nucleus; DNA binding;
NUMA1	5	nucleolus; cytoplasm; nucleoplasm; mitotic cell cycle; nucleus;
PGR	5	nucleolus; cytoplasm; nucleoplasm; nucleus; DNA binding;
RAD9A	5	nucleolus; cytoplasm; nucleoplasm; DNA replication; nucleus;
RBPJ	5	nucleolus; cytoplasm; nucleoplasm; nucleus; DNA binding;
SART1	5	nucleolus; cytoplasm; nucleoplasm; nucleus; molecular_function;
ZNF77	5	nucleolus; cytoplasm; nucleus; molecular_function; DNA binding;

Genes shared at least 2 KEGG pathways with POLA2 (count: 15)

Gene Symbol	Pathway Count	Pathway List
POLD3	4	Purine metabolism; Metabolic pathways; DNA replication; Pyrimidine metabolism;
POLD4	4	Purine metabolism; Metabolic pathways; DNA replication; Pyrimidine metabolism;
POLE	4	Purine metabolism; Metabolic pathways; DNA replication; Pyrimidine metabolism;
POLE3	4	Purine metabolism; Metabolic pathways; DNA replication; Pyrimidine metabolism;
ITPA	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
NT5M	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
POLR1A	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
POLR2G	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
RRM2	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
APRT	2	Purine metabolism; Metabolic pathways;
ATIC	2	Purine metabolism; Metabolic pathways;
ENPP1	2	Purine metabolism; Metabolic pathways;
ENPP3	2	Purine metabolism; Metabolic pathways;
POLR3E	2	Purine metabolism; Pyrimidine metabolism;
UPB1	2	Metabolic pathways; Pyrimidine metabolism;

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Region: chr11:65029233..65073060 View in gBrowse