ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	POLA2
Symbol Alias	FLJ21662
Approved Name	polymerase (DNA directed), alpha 2, accessory subunit
Previous Name	"polymerase (DNA directed), alpha 2 (70kD subunit)"
Name Alias	"DNA polymerase alpha subunit B", "DNA polymerase alpha 70 kDa subunit"
Location	11q13
Position	chr11:65029233-65073060, 1
External Links	HGNC: 30073 Entrez Gene: 23649 Ensembl: ENSG00000014138 UCSC: uc001odj.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006270	DNA replication initiation	biological process	TAS	2
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0003677	DNA binding	molecular function	IEA	257
GO:0032201	telomere maintenance via semi-conservative replication	biological process	TAS	4
GO:0000060	protein import into nucleus, translocation	biological process	IEA	5
GO:0000722	telomere maintenance via recombination	biological process	TAS	5
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0005658	alpha DNA polymerase:primase complex	cellular component	IEA	1
GO:0000278	mitotic cell cycle	biological process	TAS	66
GO:0005634	nucleus	cellular component	IDA; NAS	877
GO:0000082	G1/S transition of mitotic cell cycle	biological process	TAS	27
GO:0005730	nucleolus	cellular component	IDA	271
GO:0003674	molecular_function	molecular function	ND	149
GO:0006260	DNA replication	biological process	NAS[8223465]	31
GO:0006271	DNA strand elongation involved in DNA replication	biological process	TAS	6
GO:0000084	S phase of mitotic cell cycle	biological process	TAS	19
GO:0000216	M/G1 transition of mitotic cell cycle	biological process	TAS	12
GO:0000723	telomere maintenance	biological process	TAS	11
GO:0046982	protein heterodimerization activity	molecular function	IEA	73
GO:0003887	DNA-directed DNA polymerase activity	molecular function	IEA	5

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene
hsa00230	Purine metabolism	27
hsa00240	Pyrimidine metabolism	14
hsa03030	DNA replication	6

Genes shared at least 5 GO terms with POLA2 (count: 34)

Gene Symbol	Pathway Count	Pathway List
FEN1	11	DNA binding; telomere maintenance via semi-conservative replication; telomere maintenance via recombination; nucleoplasm; mitotic cell cycle; nucleus; nucleolus; DNA replication; DNA strand elongation involved in DNA replication; S phase of mitotic cell cycle; telomere maintenance;
CDC45	10	DNA replication initiation; cytoplasm; nucleoplasm; mitotic cell cycle; nucleus; G1/S transition of mitotic cell cycle; DNA replication; DNA strand elongation involved in DNA replication; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle;
POLD4	10	telomere maintenance via semi-conservative replication; telomere maintenance via recombination; nucleoplasm; mitotic cell cycle; nucleus; DNA replication; DNA strand elongation involved in DNA replication; S phase of mitotic cell cycle; telomere maintenance; DNA-directed DNA polymerase activity;
POLD3	10	telomere maintenance via semi-conservative replication; telomere maintenance via recombination; nucleoplasm; mitotic cell cycle; nucleus; nucleolus; DNA strand elongation involved in DNA replication; S phase of mitotic cell cycle; telomere maintenance; DNA-directed DNA polymerase activity;
CDT1	8	DNA binding; nucleoplasm; mitotic cell cycle; nucleus; G1/S transition of mitotic cell cycle; DNA replication; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle;
PSMC3	7	cytoplasm; nucleoplasm; mitotic cell cycle; nucleus; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle;
SMC1A	6	cytoplasm; nucleoplasm; mitotic cell cycle; nucleus; nucleolus; protein heterodimerization activity;
SSRP1	6	cytoplasm; DNA binding; nucleoplasm; nucleus; nucleolus; DNA replication;
PSME1	6	cytoplasm; nucleoplasm; mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle;
TAF4B	6	cytoplasm; DNA binding; nucleoplasm; nucleus; nucleolus; protein heterodimerization activity;
XRCC5	6	cytoplasm; DNA binding; nucleoplasm; nucleus; nucleolus; telomere maintenance;
DHX9	5	cytoplasm; DNA binding; nucleoplasm; nucleus; nucleolus;
RAD9A	5	cytoplasm; nucleoplasm; nucleus; nucleolus; DNA replication;
SART1	5	cytoplasm; nucleoplasm; nucleus; nucleolus; molecular_function;
ZNF77	5	cytoplasm; DNA binding; nucleus; nucleolus; molecular_function;
FUS	5	cytoplasm; DNA binding; nucleoplasm; nucleus; nucleolus;
RRM2	5	cytoplasm; nucleoplasm; mitotic cell cycle; G1/S transition of mitotic cell cycle; DNA replication;
RBPJ	5	cytoplasm; DNA binding; nucleoplasm; nucleus; nucleolus;
ATXN1	5	cytoplasm; DNA binding; nucleoplasm; nucleus; nucleolus;
RCC1	5	cytoplasm; nucleoplasm; nucleus; G1/S transition of mitotic cell cycle; nucleolus;
CEP57	5	cytoplasm; protein import into nucleus, translocation; mitotic cell cycle; nucleus; nucleolus;
NUMA1	5	cytoplasm; nucleoplasm; mitotic cell cycle; nucleus; nucleolus;
PGR	5	cytoplasm; DNA binding; nucleoplasm; nucleus; nucleolus;
MAPK1	5	cytoplasm; DNA binding; nucleoplasm; nucleus; nucleolus;
SMC3	5	cytoplasm; nucleoplasm; mitotic cell cycle; nucleus; protein heterodimerization activity;
TAF13	5	DNA binding; nucleoplasm; nucleus; nucleolus; protein heterodimerization activity;
HINFP	5	DNA binding; nucleoplasm; nucleus; G1/S transition of mitotic cell cycle; nucleolus;
PSMD7	5	nucleoplasm; mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle;
PSMD5	5	nucleoplasm; mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle;
PSMB7	5	nucleoplasm; mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle;
UBC	5	nucleoplasm; mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle;
CCND1	5	nucleoplasm; mitotic cell cycle; nucleus; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle;
UBB	5	nucleoplasm; mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle;
PSME2	5	nucleoplasm; mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle;

Genes shared at least 2 KEGG pathways with POLA2 (count: 11)

Gene Symbol	Pathway Count	Pathway List
POLD3	3	Purine metabolism; Pyrimidine metabolism; DNA replication;
POLD4	3	Purine metabolism; Pyrimidine metabolism; DNA replication;
POLE3	3	Purine metabolism; Pyrimidine metabolism; DNA replication;
NT5C2	2	Purine metabolism; Pyrimidine metabolism;
POLR3K	2	Purine metabolism; Pyrimidine metabolism;
ITPA	2	Purine metabolism; Pyrimidine metabolism;
NME4	2	Purine metabolism; Pyrimidine metabolism;
POLR2G	2	Purine metabolism; Pyrimidine metabolism;
RRM2	2	Purine metabolism; Pyrimidine metabolism;
POLR1A	2	Purine metabolism; Pyrimidine metabolism;
NT5M	2	Purine metabolism; Pyrimidine metabolism;

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Region: chr11:65029233..65073060 View in gBrowse