ADHDgene Database

Gene Report

Basic Info

Approved Symbol	ATIC
Symbol Alias	PURH, AICARFT, IMPCHASE
Approved Name	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Name Alias	phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
Location	2q35
Position	chr2:216176540-216214496, +
External Links	HGNC: 794 Entrez Gene: 471 Ensembl: ENSG00000138363 UCSC: uc002vex.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003937	IMP cyclohydrolase activity	Molecular Function		1
GO:0003360	brainstem development	Biological Process		2
GO:0006139	nucleobase-containing compound metabolic process	Biological Process	TAS[8567683]	5
GO:0005829	cytosol	Cellular Component		447
GO:0005739	mitochondrion	Cellular Component		183
GO:0004643	phosphoribosylaminoimidazolecarboxamide formyltransferase activity	Molecular Function		1
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	Biological Process		2
GO:0009116	nucleoside metabolic process	Biological Process		1
GO:0006189	'de novo' IMP biosynthetic process	Biological Process		1
GO:0006144	purine nucleobase metabolic process	Biological Process		4
GO:0031100	organ regeneration	Biological Process		11
GO:0021987	cerebral cortex development	Biological Process		11
GO:0021549	cerebellum development	Biological Process		4
GO:0010035	response to inorganic substance	Biological Process		2
GO:0055086	nucleobase-containing small molecule metabolic process	Biological Process		9
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0042803	protein homodimerization activity	Molecular Function	IPI[14966129]	113
GO:0046654	tetrahydrofolate biosynthetic process	Biological Process		2
GO:0046452	dihydrofolate metabolic process	Biological Process		1

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene
hsa00230	Purine metabolism	22
hsa01100	Metabolic pathways	237
hsa00670	One carbon pool by folate	6

Genes shared at least 5 GO terms with ATIC (count: 1)

Gene Symbol	Pathway Count	Pathway List
ADAL	5	cytosol; purine ribonucleoside monophosphate biosynthetic process; purine nucleobase metabolic process; nucleobase-containing small molecule metabolic process; small molecule metabolic process;

Genes shared at least 2 KEGG pathways with ATIC (count: 17)

Gene Symbol	Pathway Count	Pathway List
APRT	2	Purine metabolism; Metabolic pathways;
ENPP1	2	Purine metabolism; Metabolic pathways;
ENPP3	2	Purine metabolism; Metabolic pathways;
ITPA	2	Purine metabolism; Metabolic pathways;
NT5M	2	Purine metabolism; Metabolic pathways;
POLA2	2	Purine metabolism; Metabolic pathways;
POLD3	2	Purine metabolism; Metabolic pathways;
POLD4	2	Purine metabolism; Metabolic pathways;
POLE	2	Purine metabolism; Metabolic pathways;
POLE3	2	Purine metabolism; Metabolic pathways;
POLR1A	2	Purine metabolism; Metabolic pathways;
POLR2G	2	Purine metabolism; Metabolic pathways;
RRM2	2	Purine metabolism; Metabolic pathways;
MTHFD2L	2	Metabolic pathways; One carbon pool by folate;
MTHFR	2	Metabolic pathways; One carbon pool by folate;
SHMT1	2	Metabolic pathways; One carbon pool by folate;
SHMT2	2	Metabolic pathways; One carbon pool by folate;

View in gBrowse

Region: chr2:216176540..216214496 View in gBrowse