ADHDgene Database

Gene Report

Basic Info

Approved Symbol	POLR1A
Symbol Alias	DKFZP586M0122, FLJ21915, RPO1-4, RPA1
Approved Name	polymerase (RNA) I polypeptide A, 194kDa
Location	2p11.2
Position	chr2:86253451-86333278, -
External Links	HGNC: 17264 Entrez Gene: 25885 Ensembl: ENSG00000068654 UCSC: uc002sqs.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_13	chr2:86219282-86401846 (NCBI Build 35 (hg17))	182565	2p11.2	Duplication	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

ID	Name	Type	No. of Genes in ADHDgene
GO:0006361	transcription initiation from RNA polymerase I promoter	Biological Process	6
GO:0006360	transcription from RNA polymerase I promoter	Biological Process	6
GO:0006363	termination of RNA polymerase I transcription	Biological Process	4
GO:0006362	transcription elongation from RNA polymerase I promoter	Biological Process	4
GO:0005515	protein binding	Molecular Function	910
GO:0003899	DNA-directed RNA polymerase activity	Molecular Function	3
GO:0005736	DNA-directed RNA polymerase I complex	Cellular Component	1
GO:0005654	nucleoplasm	Cellular Component	183
GO:0003677	DNA binding	Molecular Function	220
GO:0008270	zinc ion binding	Molecular Function	323
GO:0010467	gene expression	Biological Process	140

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene
hsa03020	RNA polymerase	3
hsa00230	Purine metabolism	22
hsa01100	Metabolic pathways	237
hsa00240	Pyrimidine metabolism	13

Genes shared at least 5 GO terms with POLR1A (count: 8)

Gene Symbol	Pathway Count	Pathway List
TAF1C	7	transcription initiation from RNA polymerase I promoter; transcription from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription elongation from RNA polymerase I promoter; nucleoplasm; DNA binding; gene expression;
GTF2H3	6	transcription initiation from RNA polymerase I promoter; transcription from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription elongation from RNA polymerase I promoter; nucleoplasm; gene expression;
TAF1B	6	transcription initiation from RNA polymerase I promoter; transcription from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription elongation from RNA polymerase I promoter; nucleoplasm; gene expression;
MAPK3	5	transcription initiation from RNA polymerase I promoter; transcription from RNA polymerase I promoter; protein binding; nucleoplasm; gene expression;
ESRRA	5	protein binding; nucleoplasm; DNA binding; zinc ion binding; gene expression;
FUS	5	protein binding; nucleoplasm; DNA binding; zinc ion binding; gene expression;
NR5A1	5	protein binding; nucleoplasm; DNA binding; zinc ion binding; gene expression;
PGR	5	protein binding; nucleoplasm; DNA binding; zinc ion binding; gene expression;

Genes shared at least 2 KEGG pathways with POLR1A (count: 15)

Gene Symbol	Pathway Count	Pathway List
POLR2G	4	RNA polymerase; Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
POLR3E	3	RNA polymerase; Purine metabolism; Pyrimidine metabolism;
ITPA	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
NT5M	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
POLA2	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
POLD3	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
POLD4	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
POLE	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
POLE3	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
RRM2	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
APRT	2	Purine metabolism; Metabolic pathways;
ATIC	2	Purine metabolism; Metabolic pathways;
ENPP1	2	Purine metabolism; Metabolic pathways;
ENPP3	2	Purine metabolism; Metabolic pathways;
UPB1	2	Metabolic pathways; Pyrimidine metabolism;

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Region: chr2:86253451..86333278 View in gBrowse