ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RRM2
Approved Name	ribonucleotide reductase M2
Previous Name	"ribonucleotide reductase M2 polypeptide"
Location	2p25-p24
Position	chr2:10262455-10271545, 1
External Links	HGNC: 10452 Entrez Gene: 6241 Ensembl: ENSG00000171848 UCSC: uc021vdr.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2p25.1	chr2:7100000-12200000	2 (1/0/1)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	molecular function	ISS; NAS[1627826]	1
GO:0005515	protein binding	molecular function	IPI	1015
GO:0000082	G1/S transition of mitotic cell cycle	biological process	TAS	27
GO:0015949	nucleobase-containing small molecule interconversion	biological process	TAS	3
GO:0046914	transition metal ion binding	molecular function	IEA	3
GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	biological process	TAS	7
GO:0005737	cytoplasm	cellular component	NAS	781
GO:0009186	deoxyribonucleoside diphosphate metabolic process	biological process	IEA	1
GO:0005971	ribonucleoside-diphosphate reductase complex	cellular component	IEA	1
GO:0055086	nucleobase-containing small molecule metabolic process	biological process	TAS	12
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0009263	deoxyribonucleotide biosynthetic process	biological process	ISS	1
GO:0006260	DNA replication	biological process	IEA; NAS	31
GO:0000278	mitotic cell cycle	biological process	TAS	66
GO:0005829	cytosol	cellular component	TAS	485

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene
hsa00230	Purine metabolism	27
hsa00240	Pyrimidine metabolism	14
hsa04115	p53 signaling pathway	14
hsa00480	Glutathione metabolism	8

Genes shared at least 5 GO terms with RRM2 (count: 17)

Gene Symbol	Pathway Count	Pathway List
CDT1	7	protein binding; G1/S transition of mitotic cell cycle; regulation of transcription involved in G1/S phase of mitotic cell cycle; nucleoplasm; DNA replication; mitotic cell cycle; cytosol;
PSMC3	7	protein binding; G1/S transition of mitotic cell cycle; cytoplasm; small molecule metabolic process; nucleoplasm; mitotic cell cycle; cytosol;
CDC45	7	protein binding; G1/S transition of mitotic cell cycle; regulation of transcription involved in G1/S phase of mitotic cell cycle; cytoplasm; nucleoplasm; DNA replication; mitotic cell cycle;
PSMD7	6	protein binding; G1/S transition of mitotic cell cycle; small molecule metabolic process; nucleoplasm; mitotic cell cycle; cytosol;
TXN	6	protein binding; nucleobase-containing small molecule interconversion; nucleobase-containing small molecule metabolic process; small molecule metabolic process; nucleoplasm; cytosol;
PSMB7	6	protein binding; G1/S transition of mitotic cell cycle; small molecule metabolic process; nucleoplasm; mitotic cell cycle; cytosol;
PSMD5	6	protein binding; G1/S transition of mitotic cell cycle; small molecule metabolic process; nucleoplasm; mitotic cell cycle; cytosol;
PSME1	6	G1/S transition of mitotic cell cycle; cytoplasm; small molecule metabolic process; nucleoplasm; mitotic cell cycle; cytosol;
DHFRP1	6	G1/S transition of mitotic cell cycle; regulation of transcription involved in G1/S phase of mitotic cell cycle; small molecule metabolic process; nucleoplasm; mitotic cell cycle; cytosol;
SKP2	5	protein binding; G1/S transition of mitotic cell cycle; nucleoplasm; mitotic cell cycle; cytosol;
CCND1	5	protein binding; G1/S transition of mitotic cell cycle; nucleoplasm; mitotic cell cycle; cytosol;
XPO1	5	protein binding; cytoplasm; nucleoplasm; mitotic cell cycle; cytosol;
NUMA1	5	protein binding; cytoplasm; nucleoplasm; mitotic cell cycle; cytosol;
UBC	5	protein binding; G1/S transition of mitotic cell cycle; nucleoplasm; mitotic cell cycle; cytosol;
UBB	5	protein binding; G1/S transition of mitotic cell cycle; nucleoplasm; mitotic cell cycle; cytosol;
POLA2	5	G1/S transition of mitotic cell cycle; cytoplasm; nucleoplasm; DNA replication; mitotic cell cycle;
PSME2	5	G1/S transition of mitotic cell cycle; small molecule metabolic process; nucleoplasm; mitotic cell cycle; cytosol;

Genes shared at least 2 KEGG pathways with RRM2 (count: 11)

Gene Symbol	Pathway Count	Pathway List
NT5C2	2	Purine metabolism; Pyrimidine metabolism;
POLA2	2	Purine metabolism; Pyrimidine metabolism;
POLR3K	2	Purine metabolism; Pyrimidine metabolism;
POLD3	2	Purine metabolism; Pyrimidine metabolism;
POLD4	2	Purine metabolism; Pyrimidine metabolism;
ITPA	2	Purine metabolism; Pyrimidine metabolism;
NME4	2	Purine metabolism; Pyrimidine metabolism;
POLR2G	2	Purine metabolism; Pyrimidine metabolism;
POLE3	2	Purine metabolism; Pyrimidine metabolism;
POLR1A	2	Purine metabolism; Pyrimidine metabolism;
NT5M	2	Purine metabolism; Pyrimidine metabolism;

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Region: chr2:10262455..10271545 View in gBrowse