ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RRM2
Approved Name	ribonucleotide reductase M2
Previous Name	ribonucleotide reductase M2 polypeptide
Location	2p25-p24
Position	chr2:10262455-10271546, +
External Links	HGNC: 10452 Entrez Gene: 6241 Ensembl: ENSG00000171848 UCSC: uc002rah.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2p25.1	chr2:7100000-12200000	2 (1/0/1)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0046914	transition metal ion binding	Molecular Function		3
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0015949	nucleobase-containing small molecule interconversion	Biological Process		2
GO:0009263	deoxyribonucleotide biosynthetic process	Biological Process		1
GO:0055086	nucleobase-containing small molecule metabolic process	Biological Process		9
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	Molecular Function	NAS[1627826]	1
GO:0005515	protein binding	Molecular Function		910
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005737	cytoplasm	Cellular Component		690
GO:0005829	cytosol	Cellular Component		447
GO:0005971	ribonucleoside-diphosphate reductase complex	Cellular Component		1
GO:0006260	DNA replication	Biological Process		27
GO:0009186	deoxyribonucleoside diphosphate metabolic process	Biological Process		1
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process		26
GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	Biological Process		7
GO:0000278	mitotic cell cycle	Biological Process		63

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00230	Purine metabolism	22
hsa01100	Metabolic pathways	237
hsa00240	Pyrimidine metabolism	13
hsa04115	p53 signaling pathway	14	p53 activation is induced by a number of stress signals, inc...... p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways. More...
hsa00480	Glutathione metabolism	9

Genes shared at least 5 GO terms with RRM2 (count: 17)

Gene Symbol	Pathway Count	Pathway List
PSMC3	7	small molecule metabolic process; protein binding; nucleoplasm; cytoplasm; cytosol; G1/S transition of mitotic cell cycle; mitotic cell cycle;
CDC45	7	protein binding; nucleoplasm; cytoplasm; DNA replication; G1/S transition of mitotic cell cycle; regulation of transcription involved in G1/S phase of mitotic cell cycle; mitotic cell cycle;
CDT1	7	protein binding; nucleoplasm; cytosol; DNA replication; G1/S transition of mitotic cell cycle; regulation of transcription involved in G1/S phase of mitotic cell cycle; mitotic cell cycle;
DHFRP1	6	small molecule metabolic process; nucleoplasm; cytosol; G1/S transition of mitotic cell cycle; regulation of transcription involved in G1/S phase of mitotic cell cycle; mitotic cell cycle;
PSMB7	6	small molecule metabolic process; protein binding; nucleoplasm; cytosol; G1/S transition of mitotic cell cycle; mitotic cell cycle;
PSMD5	6	small molecule metabolic process; protein binding; nucleoplasm; cytosol; G1/S transition of mitotic cell cycle; mitotic cell cycle;
PSMD7	6	small molecule metabolic process; protein binding; nucleoplasm; cytosol; G1/S transition of mitotic cell cycle; mitotic cell cycle;
PSME1	6	small molecule metabolic process; nucleoplasm; cytoplasm; cytosol; G1/S transition of mitotic cell cycle; mitotic cell cycle;
TXN	6	small molecule metabolic process; nucleobase-containing small molecule interconversion; nucleobase-containing small molecule metabolic process; protein binding; nucleoplasm; cytosol;
PSME2	5	small molecule metabolic process; nucleoplasm; cytosol; G1/S transition of mitotic cell cycle; mitotic cell cycle;
CCND1	5	protein binding; nucleoplasm; cytosol; G1/S transition of mitotic cell cycle; mitotic cell cycle;
NUMA1	5	protein binding; nucleoplasm; cytoplasm; cytosol; mitotic cell cycle;
SKP2	5	protein binding; nucleoplasm; cytosol; G1/S transition of mitotic cell cycle; mitotic cell cycle;
UBB	5	protein binding; nucleoplasm; cytosol; G1/S transition of mitotic cell cycle; mitotic cell cycle;
UBC	5	protein binding; nucleoplasm; cytosol; G1/S transition of mitotic cell cycle; mitotic cell cycle;
XPO1	5	protein binding; nucleoplasm; cytoplasm; cytosol; mitotic cell cycle;
POLA2	5	nucleoplasm; cytoplasm; DNA replication; G1/S transition of mitotic cell cycle; mitotic cell cycle;

Genes shared at least 2 KEGG pathways with RRM2 (count: 18)

Gene Symbol	Pathway Count	Pathway List
ITPA	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
NT5M	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
POLA2	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
POLD3	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
POLD4	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
POLE	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
POLE3	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
POLR1A	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
POLR2G	3	Purine metabolism; Metabolic pathways; Pyrimidine metabolism;
APRT	2	Purine metabolism; Metabolic pathways;
ATIC	2	Purine metabolism; Metabolic pathways;
ENPP1	2	Purine metabolism; Metabolic pathways;
ENPP3	2	Purine metabolism; Metabolic pathways;
POLR3E	2	Purine metabolism; Pyrimidine metabolism;
GGT1	2	Metabolic pathways; Glutathione metabolism;
GGT5	2	Metabolic pathways; Glutathione metabolism;
ODC1	2	Metabolic pathways; Glutathione metabolism;
UPB1	2	Metabolic pathways; Pyrimidine metabolism;

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Region: chr2:10262455..10271546 View in gBrowse