ADHDgene Database

Gene Report

Basic Info

Approved Symbol	GGT1
Previous Symbol	GGT
Symbol Alias	D22S672, D22S732, CD224
Approved Name	gamma-glutamyltransferase 1
Location	22q11.23
Position	chr22:24979718-25024972, +
External Links	HGNC: 4250 Entrez Gene: 2678 Ensembl: ENSG00000100031 UCSC: uc003aan.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_37	chr22:22020325-23326630 (NCBI Build 36.1 (hg18))	1306306	22q11.23	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003840	gamma-glutamyltransferase activity	Molecular Function	TAS[18357469]	4
GO:0005515	protein binding	Molecular Function	IPI[15528406]	910
GO:0002682	regulation of immune system process	Biological Process		3
GO:0050727	regulation of inflammatory response	Biological Process		8
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0031362	anchored to external side of plasma membrane	Cellular Component	TAS[18357469]	5
GO:0019370	leukotriene biosynthetic process	Biological Process	IMP[14754911]	10
GO:0019344	cysteine biosynthetic process	Biological Process		1
GO:0016787	hydrolase activity	Molecular Function		12
GO:0016021	integral to membrane	Cellular Component		845
GO:0016020	membrane	Cellular Component		139
GO:0007283	spermatogenesis	Biological Process		35
GO:0006805	xenobiotic metabolic process	Biological Process		25
GO:0006750	glutathione biosynthetic process	Biological Process		4
GO:0006749	glutathione metabolic process	Biological Process	TAS[18357469]	7
GO:0006520	cellular amino acid metabolic process	Biological Process	TAS[2904146]	8
GO:0005886	plasma membrane	Cellular Component		772

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene
hsa01100	Metabolic pathways	237
hsa00590	Arachidonic acid metabolism	16
hsa00480	Glutathione metabolism	9
hsa00460	Cyanoamino acid metabolism	4
hsa00430	Taurine and hypotaurine metabolism	3

Genes shared at least 5 GO terms with GGT1 (count: 4)

Gene Symbol	Pathway Count	Pathway List
GGT5	9	gamma-glutamyltransferase activity; anchored to external side of plasma membrane; leukotriene biosynthetic process; hydrolase activity; integral to membrane; glutathione biosynthetic process; glutathione metabolic process; cellular amino acid metabolic process; plasma membrane;
GGTA1P	5	gamma-glutamyltransferase activity; anchored to external side of plasma membrane; leukotriene biosynthetic process; integral to membrane; glutathione metabolic process;
ACHE	5	protein binding; small molecule metabolic process; hydrolase activity; membrane; plasma membrane;
ADCY4	5	protein binding; small molecule metabolic process; integral to membrane; membrane; plasma membrane;

Genes shared at least 2 KEGG pathways with GGT1 (count: 20)

Gene Symbol	Pathway Count	Pathway List
GGT5	5	Metabolic pathways; Arachidonic acid metabolism; Glutathione metabolism; Cyanoamino acid metabolism; Taurine and hypotaurine metabolism;
BAAT	2	Metabolic pathways; Taurine and hypotaurine metabolism;
CYP2E1	2	Metabolic pathways; Arachidonic acid metabolism;
LTC4S	2	Metabolic pathways; Arachidonic acid metabolism;
ODC1	2	Metabolic pathways; Glutathione metabolism;
PLA2G10	2	Metabolic pathways; Arachidonic acid metabolism;
PLA2G1B	2	Metabolic pathways; Arachidonic acid metabolism;
PLA2G2A	2	Metabolic pathways; Arachidonic acid metabolism;
PLA2G2D	2	Metabolic pathways; Arachidonic acid metabolism;
PLA2G2E	2	Metabolic pathways; Arachidonic acid metabolism;
PLA2G3	2	Metabolic pathways; Arachidonic acid metabolism;
PLA2G4B	2	Metabolic pathways; Arachidonic acid metabolism;
PLA2G5	2	Metabolic pathways; Arachidonic acid metabolism;
PLA2G6	2	Metabolic pathways; Arachidonic acid metabolism;
PTGS1	2	Metabolic pathways; Arachidonic acid metabolism;
RRM2	2	Metabolic pathways; Glutathione metabolism;
SHMT1	2	Metabolic pathways; Cyanoamino acid metabolism;
SHMT2	2	Metabolic pathways; Cyanoamino acid metabolism;
GPX5	2	Arachidonic acid metabolism; Glutathione metabolism;
GPX6	2	Arachidonic acid metabolism; Glutathione metabolism;

View in gBrowse

Region: chr22:24979718..25024972 View in gBrowse