ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PSME1
Symbol Alias	IFI5111, PA28alpha
Approved Name	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
Location	14q11.2
Position	chr14:24605367-24608176, 1
External Links	HGNC: 9568 Entrez Gene: 5720 Ensembl: ENSG00000092010 UCSC: uc001wmh.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
14q12	chr14:24600000-33300000	1 (1/0/0)

Gene related GO terms (count: 28)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 28)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016070	RNA metabolic process	biological process	TAS	54
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological process	TAS	12
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0042981	regulation of apoptotic process	biological process	TAS	34
GO:0006521	regulation of cellular amino acid metabolic process	biological process	TAS	9
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological process	TAS	12
GO:0000084	S phase of mitotic cell cycle	biological process	TAS	19
GO:0008537	proteasome activator complex	cellular component	IEA	2
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	biological process	TAS	18
GO:0000209	protein polyubiquitination	biological process	TAS	26
GO:0006915	apoptotic process	biological process	TAS	127
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS	30
GO:0005829	cytosol	cellular component	TAS	485
GO:0000216	M/G1 transition of mitotic cell cycle	biological process	TAS	12
GO:0000075	cell cycle checkpoint	biological process	TAS	21
GO:0016032	viral reproduction	biological process	TAS	66
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological process	TAS	10
GO:0000278	mitotic cell cycle	biological process	TAS	66
GO:0000082	G1/S transition of mitotic cell cycle	biological process	TAS	27
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	biological process	TAS	14
GO:0010467	gene expression	biological process	TAS	154
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	biological process	TAS	10
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	biological process	TAS	14
GO:0005737	cytoplasm	cellular component	TAS[16130169]	781
GO:0016071	mRNA metabolic process	biological process	TAS	41
GO:0000502	proteasome complex	cellular component	TAS[8811196]	14
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	biological process	TAS	14

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04612	Antigen processing and presentation	12

Genes shared at least 5 GO terms with PSME1 (count: 48)

Gene Symbol	Pathway Count	Pathway List
PSMC3	27	RNA metabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; small molecule metabolic process; regulation of apoptotic process; regulation of cellular amino acid metabolic process; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; S phase of mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; protein polyubiquitination; apoptotic process; cellular nitrogen compound metabolic process; cytosol; M/G1 transition of mitotic cell cycle; cell cycle checkpoint; viral reproduction; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle; G1/S transition of mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; antigen processing and presentation of exogenous peptide antigen via MHC class I; cytoplasm; mRNA metabolic process; proteasome complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
PSME2	27	RNA metabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; small molecule metabolic process; regulation of apoptotic process; regulation of cellular amino acid metabolic process; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; S phase of mitotic cell cycle; proteasome activator complex; antigen processing and presentation of peptide antigen via MHC class I; protein polyubiquitination; apoptotic process; cellular nitrogen compound metabolic process; cytosol; M/G1 transition of mitotic cell cycle; cell cycle checkpoint; viral reproduction; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle; G1/S transition of mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; antigen processing and presentation of exogenous peptide antigen via MHC class I; mRNA metabolic process; proteasome complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
PSMD7	26	RNA metabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; small molecule metabolic process; regulation of apoptotic process; regulation of cellular amino acid metabolic process; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; S phase of mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; protein polyubiquitination; apoptotic process; cellular nitrogen compound metabolic process; cytosol; M/G1 transition of mitotic cell cycle; cell cycle checkpoint; viral reproduction; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle; G1/S transition of mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; antigen processing and presentation of exogenous peptide antigen via MHC class I; mRNA metabolic process; proteasome complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
PSMD5	26	RNA metabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; small molecule metabolic process; regulation of apoptotic process; regulation of cellular amino acid metabolic process; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; S phase of mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; protein polyubiquitination; apoptotic process; cellular nitrogen compound metabolic process; cytosol; M/G1 transition of mitotic cell cycle; cell cycle checkpoint; viral reproduction; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle; G1/S transition of mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; antigen processing and presentation of exogenous peptide antigen via MHC class I; mRNA metabolic process; proteasome complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
PSMB7	26	RNA metabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; small molecule metabolic process; regulation of apoptotic process; regulation of cellular amino acid metabolic process; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; S phase of mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; protein polyubiquitination; apoptotic process; cellular nitrogen compound metabolic process; cytosol; M/G1 transition of mitotic cell cycle; cell cycle checkpoint; viral reproduction; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle; G1/S transition of mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; antigen processing and presentation of exogenous peptide antigen via MHC class I; mRNA metabolic process; proteasome complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
PSMA8	22	RNA metabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; small molecule metabolic process; regulation of apoptotic process; regulation of cellular amino acid metabolic process; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; S phase of mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; protein polyubiquitination; apoptotic process; cellular nitrogen compound metabolic process; cytosol; M/G1 transition of mitotic cell cycle; cell cycle checkpoint; viral reproduction; mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; antigen processing and presentation of exogenous peptide antigen via MHC class I; mRNA metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
UBC	22	RNA metabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of apoptotic process; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; S phase of mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; protein polyubiquitination; apoptotic process; cytosol; M/G1 transition of mitotic cell cycle; cell cycle checkpoint; viral reproduction; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle; G1/S transition of mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; antigen processing and presentation of exogenous peptide antigen via MHC class I; mRNA metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
UBB	22	RNA metabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of apoptotic process; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; S phase of mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; protein polyubiquitination; apoptotic process; cytosol; M/G1 transition of mitotic cell cycle; cell cycle checkpoint; viral reproduction; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle; G1/S transition of mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; antigen processing and presentation of exogenous peptide antigen via MHC class I; mRNA metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
XPO1	8	RNA metabolic process; nucleoplasm; cytosol; viral reproduction; mitotic cell cycle; gene expression; cytoplasm; mRNA metabolic process;
CDC26	8	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; cytosol; cell cycle checkpoint; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
ANAPC4	8	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; cytosol; cell cycle checkpoint; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
SKP2	7	nucleoplasm; S phase of mitotic cell cycle; protein polyubiquitination; cytosol; mitotic cell cycle; G1/S transition of mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
CDC45	7	nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; cell cycle checkpoint; mitotic cell cycle; G1/S transition of mitotic cell cycle; cytoplasm;
RPL35	6	RNA metabolic process; cytosol; viral reproduction; gene expression; cytoplasm; mRNA metabolic process;
RPS15A	6	RNA metabolic process; cytosol; viral reproduction; gene expression; cytoplasm; mRNA metabolic process;
RPS9	6	RNA metabolic process; cytosol; viral reproduction; gene expression; cytoplasm; mRNA metabolic process;
NCBP1	6	RNA metabolic process; nucleoplasm; cytosol; viral reproduction; gene expression; mRNA metabolic process;
RPS3	6	RNA metabolic process; cytosol; viral reproduction; gene expression; cytoplasm; mRNA metabolic process;
RPL14	6	RNA metabolic process; cytosol; viral reproduction; gene expression; cytoplasm; mRNA metabolic process;
RPS25	6	RNA metabolic process; cytosol; viral reproduction; gene expression; cytoplasm; mRNA metabolic process;
RPS2	6	RNA metabolic process; nucleoplasm; cytosol; viral reproduction; gene expression; mRNA metabolic process;
RNPS1	6	RNA metabolic process; nucleoplasm; cytosol; gene expression; cytoplasm; mRNA metabolic process;
PLK1	6	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; cytosol; mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
RRM2	6	small molecule metabolic process; nucleoplasm; cytosol; mitotic cell cycle; G1/S transition of mitotic cell cycle; cytoplasm;
CDT1	6	nucleoplasm; S phase of mitotic cell cycle; cytosol; M/G1 transition of mitotic cell cycle; mitotic cell cycle; G1/S transition of mitotic cell cycle;
POLA2	6	nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; mitotic cell cycle; G1/S transition of mitotic cell cycle; cytoplasm;
RPS10	5	RNA metabolic process; cytosol; viral reproduction; gene expression; mRNA metabolic process;
PAIP1	5	RNA metabolic process; cytosol; gene expression; cytoplasm; mRNA metabolic process;
RPL13	5	RNA metabolic process; cytosol; viral reproduction; gene expression; mRNA metabolic process;
DCPS	5	RNA metabolic process; cytosol; gene expression; cytoplasm; mRNA metabolic process;
SMG7	5	RNA metabolic process; cytosol; gene expression; cytoplasm; mRNA metabolic process;
RPL37	5	RNA metabolic process; cytosol; viral reproduction; gene expression; mRNA metabolic process;
PARN	5	RNA metabolic process; cytosol; gene expression; cytoplasm; mRNA metabolic process;
FAU	5	RNA metabolic process; cytosol; viral reproduction; gene expression; mRNA metabolic process;
TNKS1BP1	5	RNA metabolic process; cytosol; gene expression; cytoplasm; mRNA metabolic process;
RPL27A	5	RNA metabolic process; cytosol; viral reproduction; gene expression; mRNA metabolic process;
SMG1	5	RNA metabolic process; cytosol; gene expression; cytoplasm; mRNA metabolic process;
RPL12	5	RNA metabolic process; cytosol; viral reproduction; gene expression; mRNA metabolic process;
RPS12	5	RNA metabolic process; cytosol; viral reproduction; gene expression; mRNA metabolic process;
GEMIN2	5	RNA metabolic process; nucleoplasm; cytosol; gene expression; cytoplasm;
RPL37A	5	RNA metabolic process; cytosol; viral reproduction; gene expression; mRNA metabolic process;
RPL3L	5	RNA metabolic process; cytosol; viral reproduction; gene expression; mRNA metabolic process;
RPL38	5	RNA metabolic process; cytosol; viral reproduction; gene expression; mRNA metabolic process;
DHFRP1	5	small molecule metabolic process; nucleoplasm; cytosol; mitotic cell cycle; G1/S transition of mitotic cell cycle;
RAN	5	nucleoplasm; cytosol; viral reproduction; gene expression; cytoplasm;
SMC1A	5	nucleoplasm; cell cycle checkpoint; mitotic cell cycle; gene expression; cytoplasm;
CCND1	5	nucleoplasm; S phase of mitotic cell cycle; cytosol; mitotic cell cycle; G1/S transition of mitotic cell cycle;
NCF2	5	antigen processing and presentation of peptide antigen via MHC class I; cytosol; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; cytoplasm;

Genes shared at least 2 KEGG pathways with PSME1 (count: 0)

View in gBrowse

Region: chr14:24605367..24608176 View in gBrowse