ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	XPO1
Symbol Alias	CRM1, emb
Approved Name	exportin 1
Previous Name	"exportin 1 (CRM1, yeast, homolog)", "exportin 1 (CRM1 homolog, yeast)"
Name Alias	"chromosome region maintenance 1 homolog (yeast)"
Location	2p15
Position	chr2:61704984-61765761, -1
External Links	HGNC: 12825 Entrez Gene: 7514 Ensembl: ENSG00000082898 UCSC: uc002sbj.3
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Stergiakouli E., 2012	One of the top 20 independent SNPs with P=0.0000289 locates 3'-UTR relative to this gene.	Trend

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs1050567	chr2:61705663(Fwd)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant; upstream_gene_variant	1(0/0/1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 34)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 34)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0019048	virus-host interaction	biological process	IEA	61
GO:0042176	regulation of protein catabolic process	biological process	IEA	3
GO:0046825	regulation of protein export from nucleus	biological process	IEA	2
GO:0007179	transforming growth factor beta receptor signaling pathway	biological process	TAS	13
GO:0005643	nuclear pore	cellular component	IEA	11
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0019058	viral infectious cycle	biological process	TAS	19
GO:0016071	mRNA metabolic process	biological process	TAS	41
GO:0015030	Cajal body	cellular component	IEA	13
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IEA	90
GO:0005215	transporter activity	molecular function	TAS	44
GO:0010824	regulation of centrosome duplication	biological process	IEA	3
GO:0000278	mitotic cell cycle	biological process	TAS	66
GO:0034504	protein localization to nucleus	biological process	IEA	3
GO:0051028	mRNA transport	biological process	IEA	8
GO:0005730	nucleolus	cellular component	IEA	271
GO:0042493	response to drug	biological process	IEA	73
GO:0030529	ribonucleoprotein complex	cellular component	IDA[18809582]	24
GO:0010467	gene expression	biological process	TAS	154
GO:0000776	kinetochore	cellular component	IDA[17363900]	19
GO:0005635	nuclear envelope	cellular component	TAS[9368044]	22
GO:0016032	viral reproduction	biological process	TAS	66
GO:0005829	cytosol	cellular component	TAS	485
GO:0005515	protein binding	molecular function	IPI[16319068]	1015
GO:0008565	protein transporter activity	molecular function	IEA	11
GO:0003723	RNA binding	molecular function	IEA	115
GO:0016070	RNA metabolic process	biological process	TAS	54
GO:0006611	protein export from nucleus	biological process	IEA	5
GO:0005737	cytoplasm	cellular component	TAS[9368044]	781
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	biological process	TAS	16
GO:0005642	annulate lamellae	cellular component	IDA[12210765]	1
GO:0019904	protein domain specific binding	molecular function	IEA	43
GO:0000236	mitotic prometaphase	biological process	TAS	19
GO:0000087	M phase of mitotic cell cycle	biological process	TAS	21

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with XPO1 (count: 131)

Gene Symbol	Pathway Count	Pathway List
UBB	11	transforming growth factor beta receptor signaling pathway; nucleoplasm; mRNA metabolic process; negative regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; gene expression; viral reproduction; cytosol; protein binding; RNA metabolic process; negative regulation of transforming growth factor beta receptor signaling pathway;
UBC	11	transforming growth factor beta receptor signaling pathway; nucleoplasm; mRNA metabolic process; negative regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; gene expression; viral reproduction; cytosol; protein binding; RNA metabolic process; negative regulation of transforming growth factor beta receptor signaling pathway;
PSMC3	10	virus-host interaction; nucleoplasm; mRNA metabolic process; mitotic cell cycle; gene expression; viral reproduction; cytosol; protein binding; RNA metabolic process; cytoplasm;
RAN	10	virus-host interaction; nuclear pore; nucleoplasm; viral infectious cycle; gene expression; viral reproduction; cytosol; protein binding; protein export from nucleus; cytoplasm;
NEDD4L	10	virus-host interaction; regulation of protein catabolic process; transforming growth factor beta receptor signaling pathway; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; gene expression; cytosol; protein binding; cytoplasm; negative regulation of transforming growth factor beta receptor signaling pathway;
RPS2	10	nucleoplasm; viral infectious cycle; mRNA metabolic process; nucleolus; gene expression; viral reproduction; cytosol; protein binding; RNA binding; RNA metabolic process;
RPS9	10	viral infectious cycle; mRNA metabolic process; nucleolus; ribonucleoprotein complex; gene expression; viral reproduction; cytosol; protein binding; RNA metabolic process; cytoplasm;
PSMB7	9	virus-host interaction; nucleoplasm; mRNA metabolic process; mitotic cell cycle; gene expression; viral reproduction; cytosol; protein binding; RNA metabolic process;
NUP160	9	nuclear pore; mitotic cell cycle; kinetochore; nuclear envelope; viral reproduction; cytosol; protein binding; mitotic prometaphase; M phase of mitotic cell cycle;
NCBP1	9	nucleoplasm; mRNA metabolic process; ribonucleoprotein complex; gene expression; viral reproduction; cytosol; protein binding; RNA binding; RNA metabolic process;
SMC1A	9	nucleoplasm; mitotic cell cycle; nucleolus; gene expression; kinetochore; protein binding; cytoplasm; mitotic prometaphase; M phase of mitotic cell cycle;
RPL14	9	viral infectious cycle; mRNA metabolic process; gene expression; viral reproduction; cytosol; protein binding; RNA binding; RNA metabolic process; cytoplasm;
RPS3	9	viral infectious cycle; mRNA metabolic process; ribonucleoprotein complex; gene expression; viral reproduction; cytosol; protein binding; RNA metabolic process; cytoplasm;
RPS25	9	viral infectious cycle; mRNA metabolic process; nucleolus; gene expression; viral reproduction; cytosol; RNA binding; RNA metabolic process; cytoplasm;
PAFAH1B1	9	mitotic cell cycle; nucleolus; kinetochore; nuclear envelope; cytosol; protein binding; cytoplasm; mitotic prometaphase; M phase of mitotic cell cycle;
HNRNPA1	8	virus-host interaction; nucleoplasm; mRNA transport; nucleolus; ribonucleoprotein complex; gene expression; RNA binding; cytoplasm;
HSPA8	8	virus-host interaction; mRNA metabolic process; nucleolus; ribonucleoprotein complex; gene expression; cytosol; protein binding; RNA metabolic process;
MEN1	8	transforming growth factor beta receptor signaling pathway; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; nucleolus; gene expression; cytosol; protein binding; cytoplasm;
MAD1L1	8	nuclear pore; mitotic cell cycle; kinetochore; cytosol; protein binding; cytoplasm; mitotic prometaphase; M phase of mitotic cell cycle;
PSMD7	8	nucleoplasm; mRNA metabolic process; mitotic cell cycle; gene expression; viral reproduction; cytosol; protein binding; RNA metabolic process;
RNPS1	8	nucleoplasm; mRNA metabolic process; gene expression; cytosol; protein binding; RNA binding; RNA metabolic process; cytoplasm;
PSMD5	8	nucleoplasm; mRNA metabolic process; mitotic cell cycle; gene expression; viral reproduction; cytosol; protein binding; RNA metabolic process;
PSME1	8	nucleoplasm; mRNA metabolic process; mitotic cell cycle; gene expression; viral reproduction; cytosol; RNA metabolic process; cytoplasm;
PLK1	8	nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; kinetochore; cytosol; protein binding; mitotic prometaphase; M phase of mitotic cell cycle;
RPS15A	8	viral infectious cycle; mRNA metabolic process; gene expression; viral reproduction; cytosol; RNA binding; RNA metabolic process; cytoplasm;
RPL13	8	viral infectious cycle; mRNA metabolic process; gene expression; viral reproduction; cytosol; protein binding; RNA binding; RNA metabolic process;
RPL27A	8	viral infectious cycle; mRNA metabolic process; gene expression; viral reproduction; cytosol; protein binding; RNA binding; RNA metabolic process;
RPL35	8	viral infectious cycle; mRNA metabolic process; nucleolus; gene expression; viral reproduction; cytosol; RNA metabolic process; cytoplasm;
RPS10	8	viral infectious cycle; mRNA metabolic process; nucleolus; gene expression; viral reproduction; cytosol; protein binding; RNA metabolic process;
NUP62	7	nuclear pore; mRNA transport; ribonucleoprotein complex; nuclear envelope; viral reproduction; protein binding; cytoplasm;
HNRNPA2B1	7	nucleoplasm; nucleolus; ribonucleoprotein complex; gene expression; protein binding; RNA binding; cytoplasm;
GEMIN2	7	nucleoplasm; Cajal body; gene expression; cytosol; protein binding; RNA metabolic process; cytoplasm;
PSME2	7	nucleoplasm; mRNA metabolic process; mitotic cell cycle; gene expression; viral reproduction; cytosol; RNA metabolic process;
RPL3L	7	viral infectious cycle; mRNA metabolic process; gene expression; viral reproduction; cytosol; RNA binding; RNA metabolic process;
FAU	7	viral infectious cycle; mRNA metabolic process; gene expression; viral reproduction; cytosol; RNA binding; RNA metabolic process;
RPL37	7	viral infectious cycle; mRNA metabolic process; gene expression; viral reproduction; cytosol; RNA binding; RNA metabolic process;
RPL38	7	viral infectious cycle; mRNA metabolic process; gene expression; viral reproduction; cytosol; RNA binding; RNA metabolic process;
RPL12	7	viral infectious cycle; mRNA metabolic process; gene expression; viral reproduction; cytosol; RNA binding; RNA metabolic process;
DCPS	7	mRNA metabolic process; nucleolus; gene expression; cytosol; protein binding; RNA metabolic process; cytoplasm;
PAIP1	7	mRNA metabolic process; gene expression; cytosol; protein binding; RNA binding; RNA metabolic process; cytoplasm;
PARN	7	mRNA metabolic process; nucleolus; gene expression; cytosol; protein binding; RNA metabolic process; cytoplasm;
NDE1	7	mitotic cell cycle; kinetochore; cytosol; protein binding; protein domain specific binding; mitotic prometaphase; M phase of mitotic cell cycle;
GSK3B	7	nucleolus; response to drug; ribonucleoprotein complex; cytosol; protein binding; protein export from nucleus; cytoplasm;
MAPK3	6	virus-host interaction; nucleoplasm; nucleolus; gene expression; cytosol; protein binding;
SNW1	6	virus-host interaction; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; nucleolus; gene expression; protein binding;
CREBBP	6	virus-host interaction; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; gene expression; protein binding; cytoplasm;
MAPK1	6	virus-host interaction; nucleoplasm; nucleolus; cytosol; protein binding; cytoplasm;
RELA	6	virus-host interaction; nucleoplasm; response to drug; cytosol; protein binding; cytoplasm;
NXF1	6	virus-host interaction; nuclear pore; nucleoplasm; gene expression; cytosol; protein binding;
TCEB1	6	virus-host interaction; nucleoplasm; gene expression; viral reproduction; cytosol; protein binding;
PPP1CA	6	transforming growth factor beta receptor signaling pathway; nucleolus; cytosol; protein binding; cytoplasm; negative regulation of transforming growth factor beta receptor signaling pathway;
NCOR2	6	transforming growth factor beta receptor signaling pathway; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; nucleolus; gene expression; protein binding;
MVP	6	nuclear pore; mRNA transport; response to drug; ribonucleoprotein complex; protein binding; cytoplasm;
U2AF1	6	nucleoplasm; Cajal body; nucleolus; gene expression; protein binding; RNA binding;
RBPJ	6	nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; nucleolus; gene expression; protein binding; cytoplasm;
HNRNPH1	6	nucleoplasm; nucleolus; gene expression; protein binding; RNA binding; cytoplasm;
SSRP1	6	nucleoplasm; nucleolus; gene expression; viral reproduction; protein binding; cytoplasm;
SART1	6	nucleoplasm; Cajal body; nucleolus; cytosol; protein binding; cytoplasm;
SNRPD1	6	nucleoplasm; gene expression; cytosol; protein binding; RNA binding; RNA metabolic process;
NUMA1	6	nucleoplasm; mitotic cell cycle; nucleolus; cytosol; protein binding; cytoplasm;
DHX9	6	nucleoplasm; nucleolus; ribonucleoprotein complex; gene expression; protein binding; cytoplasm;
SNRPG	6	nucleoplasm; gene expression; cytosol; protein binding; RNA binding; RNA metabolic process;
FUS	6	nucleoplasm; nucleolus; gene expression; protein binding; RNA binding; cytoplasm;
SMC3	6	nucleoplasm; mitotic cell cycle; protein binding; cytoplasm; mitotic prometaphase; M phase of mitotic cell cycle;
EFTUD2	6	nucleoplasm; Cajal body; nucleolus; gene expression; protein binding; cytoplasm;
RPS12	6	viral infectious cycle; mRNA metabolic process; gene expression; viral reproduction; cytosol; RNA metabolic process;
RPL37A	6	viral infectious cycle; mRNA metabolic process; gene expression; viral reproduction; cytosol; RNA metabolic process;
LSM4	6	mRNA metabolic process; gene expression; cytosol; protein binding; RNA binding; RNA metabolic process;
SMG1	6	mRNA metabolic process; gene expression; cytosol; protein binding; RNA metabolic process; cytoplasm;
PATL1	6	mRNA metabolic process; gene expression; cytosol; protein binding; RNA binding; RNA metabolic process;
PSMA8	6	mRNA metabolic process; mitotic cell cycle; gene expression; viral reproduction; cytosol; RNA metabolic process;
DDX6	6	mRNA metabolic process; gene expression; cytosol; protein binding; RNA binding; RNA metabolic process;
SMG7	6	mRNA metabolic process; gene expression; cytosol; protein binding; RNA metabolic process; cytoplasm;
CNOT6	6	mRNA metabolic process; gene expression; cytosol; protein binding; RNA binding; RNA metabolic process;
INCENP	6	mitotic cell cycle; kinetochore; cytosol; protein binding; mitotic prometaphase; M phase of mitotic cell cycle;
ZW10	6	mitotic cell cycle; kinetochore; cytosol; protein binding; mitotic prometaphase; M phase of mitotic cell cycle;
CLASP1	6	mitotic cell cycle; kinetochore; cytosol; protein binding; mitotic prometaphase; M phase of mitotic cell cycle;
MAPRE1	6	mitotic cell cycle; cytosol; protein binding; cytoplasm; mitotic prometaphase; M phase of mitotic cell cycle;
CLASP2	6	mitotic cell cycle; cytosol; protein binding; cytoplasm; mitotic prometaphase; M phase of mitotic cell cycle;
CENPC	6	mitotic cell cycle; kinetochore; cytosol; cytoplasm; mitotic prometaphase; M phase of mitotic cell cycle;
KIF2C	6	mitotic cell cycle; kinetochore; cytosol; protein binding; mitotic prometaphase; M phase of mitotic cell cycle;
ATXN2	6	nucleolus; ribonucleoprotein complex; protein binding; RNA binding; RNA metabolic process; cytoplasm;
PDCD4	6	nucleolus; cytosol; protein binding; RNA binding; RNA metabolic process; cytoplasm;
KAT5	5	virus-host interaction; negative regulation of transcription from RNA polymerase II promoter; nucleolus; cytosol; protein binding;
DAXX	5	virus-host interaction; nucleolus; cytosol; protein binding; cytoplasm;
BNIP3	5	virus-host interaction; nucleoplasm; nuclear envelope; protein binding; cytoplasm;
HMGA1	5	virus-host interaction; nucleoplasm; viral reproduction; cytosol; protein binding;
BANF1	5	virus-host interaction; nucleoplasm; viral reproduction; cytosol; protein binding;
E4F1	5	virus-host interaction; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; protein binding; cytoplasm;
ARRB2	5	transforming growth factor beta receptor signaling pathway; cytosol; protein binding; cytoplasm; protein domain specific binding;
STUB1	5	transforming growth factor beta receptor signaling pathway; cytosol; protein binding; cytoplasm; negative regulation of transforming growth factor beta receptor signaling pathway;
NUPL2	5	nuclear pore; mRNA transport; viral reproduction; cytosol; protein export from nucleus;
SNRPD3	5	nucleoplasm; gene expression; cytosol; protein binding; RNA metabolic process;
CENPP	5	nucleoplasm; mitotic cell cycle; cytosol; mitotic prometaphase; M phase of mitotic cell cycle;
TAF10	5	nucleoplasm; gene expression; viral reproduction; protein binding; cytoplasm;
RBM4	5	nucleoplasm; nucleolus; protein binding; RNA binding; cytoplasm;
TCEB2	5	nucleoplasm; gene expression; viral reproduction; cytosol; protein binding;
CENPN	5	nucleoplasm; mitotic cell cycle; cytosol; mitotic prometaphase; M phase of mitotic cell cycle;
SF3A1	5	nucleoplasm; nucleolus; gene expression; protein binding; RNA binding;
SNRPB	5	nucleoplasm; gene expression; cytosol; protein binding; RNA metabolic process;
YAP1	5	nucleoplasm; gene expression; cytosol; protein binding; cytoplasm;
DGCR8	5	nucleoplasm; nucleolus; gene expression; protein binding; cytoplasm;
CPSF3	5	nucleoplasm; ribonucleoprotein complex; gene expression; protein binding; RNA binding;
SNRPD2	5	nucleoplasm; gene expression; cytosol; protein binding; RNA metabolic process;
PDPK1	5	nucleoplasm; cytosol; protein binding; cytoplasm; negative regulation of transforming growth factor beta receptor signaling pathway;
IRF7	5	nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; cytosol; protein binding; cytoplasm;
PRPF4	5	nucleoplasm; Cajal body; nucleolus; gene expression; protein binding;
TAF13	5	nucleoplasm; nucleolus; gene expression; viral reproduction; protein binding;
KIF23	5	nucleoplasm; mitotic cell cycle; cytosol; protein binding; M phase of mitotic cell cycle;
PGR	5	nucleoplasm; nucleolus; gene expression; protein binding; cytoplasm;
XRCC5	5	nucleoplasm; nucleolus; viral reproduction; protein binding; cytoplasm;
SNRPF	5	nucleoplasm; gene expression; cytosol; RNA binding; RNA metabolic process;
TAF4B	5	nucleoplasm; nucleolus; gene expression; viral reproduction; cytoplasm;
CCND1	5	nucleoplasm; mitotic cell cycle; response to drug; cytosol; protein binding;
MED1	5	nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; nucleolus; gene expression; protein binding;
RRM2	5	nucleoplasm; mitotic cell cycle; cytosol; protein binding; cytoplasm;
RCC1	5	nucleoplasm; nucleolus; viral reproduction; protein binding; cytoplasm;
NCL	5	nucleoplasm; nucleolus; ribonucleoprotein complex; protein binding; RNA binding;
RQCD1	5	mRNA metabolic process; gene expression; cytosol; protein binding; RNA metabolic process;
TNKS1BP1	5	mRNA metabolic process; gene expression; cytosol; RNA metabolic process; cytoplasm;
ID2	5	negative regulation of transcription from RNA polymerase II promoter; nucleolus; cytosol; protein binding; cytoplasm;
CEP164	5	mitotic cell cycle; nucleolus; cytosol; protein binding; cytoplasm;
CEP57	5	mitotic cell cycle; nucleolus; cytosol; protein binding; cytoplasm;
CKAP5	5	mitotic cell cycle; cytosol; protein binding; mitotic prometaphase; M phase of mitotic cell cycle;
SRP19	5	nucleolus; response to drug; gene expression; cytosol; cytoplasm;
ALKBH8	5	nucleolus; cytosol; protein binding; RNA binding; cytoplasm;
NCF2	5	nucleolus; response to drug; cytosol; protein binding; cytoplasm;
IARS	5	nucleolus; gene expression; cytosol; protein binding; cytoplasm;
MPHOSPH6	5	nucleolus; protein binding; RNA binding; cytoplasm; M phase of mitotic cell cycle;
SNCA	5	response to drug; cytosol; protein binding; cytoplasm; protein domain specific binding;
TJP1	5	response to drug; cytosol; protein binding; cytoplasm; protein domain specific binding;

Genes shared at least 2 KEGG pathways with XPO1 (count: 0)

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Region: chr2:61704984..61765761 View in gBrowse