ADHDgene Database

Gene Report

Basic Info

Approved Symbol	NUPL2
Symbol Alias	NLP_1, CG1, hCG1, H_RG271G13.9
Approved Name	nucleoporin like 2
Name Alias	nucleoporin-like protein 1
Location	7p15
Position	chr7:23221446-23240630, +
External Links	HGNC: 17010 Entrez Gene: 11097 Ensembl: ENSG00000136243 UCSC: uc003svu.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Lesch[2011]_6	chr7:23010000-26070000 (NCBI Build 35 (hg17))	3060000	7p15.2-7p15.3	Duplication	Paternal (affected)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
7p15	chr7:20900000-28800000	2 (1/1/0)

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005634	nucleus	Cellular Component	TAS[10358091]	770
GO:0005643	nuclear pore	Cellular Component		9
GO:0003676	nucleic acid binding	Molecular Function		41
GO:0005049	nuclear export signal receptor activity	Molecular Function	TAS[10358091]	1
GO:0010827	regulation of glucose transport	Biological Process		3
GO:0008645	hexose transport	Biological Process		6
GO:0016032	viral reproduction	Biological Process		57
GO:0015758	glucose transport	Biological Process		13
GO:0005975	carbohydrate metabolic process	Biological Process		50
GO:0005829	cytosol	Cellular Component		447
GO:0008270	zinc ion binding	Molecular Function		323
GO:0006611	protein export from nucleus	Biological Process	TAS[10358091]	4
GO:0055085	transmembrane transport	Biological Process		82
GO:0031965	nuclear membrane	Cellular Component		27
GO:0019221	cytokine-mediated signaling pathway	Biological Process		28
GO:0051028	mRNA transport	Biological Process		8
GO:0044281	small molecule metabolic process	Biological Process		248

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03013	RNA transport	15	RNA transport from the nucleus to the cytoplasm is fundamen...... RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs, are transported by specific export receptors, which belong to the karyopherin-beta family proteins. A feature of karyopherins is their regulation by the small GTPase Ran. However, general mRNA export is mechanistically different. Nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3'-end formation and even translation. More...

Genes shared at least 5 GO terms with NUPL2 (count: 6)

Gene Symbol	Pathway Count	Pathway List
NUP62	11	nuclear pore; regulation of glucose transport; hexose transport; viral reproduction; glucose transport; carbohydrate metabolic process; transmembrane transport; nuclear membrane; cytokine-mediated signaling pathway; mRNA transport; small molecule metabolic process;
NUP155	10	nuclear pore; regulation of glucose transport; hexose transport; viral reproduction; glucose transport; carbohydrate metabolic process; transmembrane transport; nuclear membrane; cytokine-mediated signaling pathway; small molecule metabolic process;
HK1	7	nucleus; hexose transport; glucose transport; carbohydrate metabolic process; cytosol; transmembrane transport; small molecule metabolic process;
XPO1	5	nuclear pore; viral reproduction; cytosol; protein export from nucleus; mRNA transport;
SLC2A3	5	hexose transport; glucose transport; carbohydrate metabolic process; transmembrane transport; small molecule metabolic process;
SLC37A4	5	hexose transport; glucose transport; carbohydrate metabolic process; transmembrane transport; small molecule metabolic process;

Genes shared at least 2 KEGG pathways with NUPL2 (count: 0)

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Region: chr7:23221446..23240630 View in gBrowse