ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SLC37A4
Previous Symbol	G6PT1, G6PT2, G6PT3
Symbol Alias	GSD1b, GSD1c, GSD1d
Approved Name	solute carrier family 37 (glucose-6-phosphate transporter), member 4
Previous Name	glucose-6-phosphatase, transport (glucose-6-phosphate) protein 1
Location	11q23.3
Position	chr11:118894824-118901616, -
External Links	HGNC: 4061 Entrez Gene: 2542 UCSC: uc010ryt.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0042593	glucose homeostasis	Biological Process	IDA[11140953]	18
GO:0030176	integral to endoplasmic reticulum membrane	Cellular Component	IDA[10318794]	14
GO:0016021	integral to membrane	Cellular Component	NAS[9428641]	845
GO:0015760	glucose-6-phosphate transport	Biological Process	IDA[11140953]; IMP[12560945]	1
GO:0015758	glucose transport	Biological Process		13
GO:0015152	glucose-6-phosphate transmembrane transporter activity	Molecular Function	IDA[11140953]; IMP[12560945]	1
GO:0008645	hexose transport	Biological Process		6
GO:0006810	transport	Biological Process	NAS[9428641]	62
GO:0006006	glucose metabolic process	Biological Process	NAS[9428641]	19
GO:0005975	carbohydrate metabolic process	Biological Process		50
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0005783	endoplasmic reticulum	Cellular Component	NAS[212064]	100
GO:0005215	transporter activity	Molecular Function	NAS[9428641]	41
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0055085	transmembrane transport	Biological Process		82

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04973	Carbohydrate digestion and absorption	9	Dietary carbohydrate in humans and omnivorous animals is a m...... Dietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we ingest vary from the lactose in milk to complex carbohydrates. These carbohydrates are digested to monosaccharides, mostly glucose, galactose and fructose, prior to absorption in the small intestine. Glucose and galactose are initially transported into the enterocyte by SGLT1 located in the apical brush border membrane and then exit through the basolateral membrane by either GLUT2 or exocytosis. In a new model of intestinal glucose absorption, transport by SGLT1 induces rapid insertion and activation of GLUT2 in the brush border membrane by a PKC betaII-dependent mechanism. Moreover, trafficking of apical GLUT2 is rapidly up-regulated by glucose and artificial sweeteners, which act through T1R2 + T1R3/alpha-gustducin to activate PLC-beta2 and PKC-beta II. Fructose is transported separately by the brush border GLUT5 and then released out of the enterocyte into the blood by GLUT2. More...

Genes shared at least 5 GO terms with SLC37A4 (count: 7)

Gene Symbol	Pathway Count	Pathway List
SLC2A3	6	integral to membrane; glucose transport; hexose transport; carbohydrate metabolic process; small molecule metabolic process; transmembrane transport;
NUP155	6	glucose transport; hexose transport; carbohydrate metabolic process; transporter activity; small molecule metabolic process; transmembrane transport;
DGAT2	5	integral to endoplasmic reticulum membrane; integral to membrane; endoplasmic reticulum membrane; endoplasmic reticulum; small molecule metabolic process;
ABCG2	5	integral to membrane; transport; transporter activity; small molecule metabolic process; transmembrane transport;
HK1	5	glucose transport; hexose transport; carbohydrate metabolic process; small molecule metabolic process; transmembrane transport;
NUP62	5	glucose transport; hexose transport; carbohydrate metabolic process; small molecule metabolic process; transmembrane transport;
NUPL2	5	glucose transport; hexose transport; carbohydrate metabolic process; small molecule metabolic process; transmembrane transport;

Genes shared at least 2 KEGG pathways with SLC37A4 (count: 0)

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Region: chr11:118894824..118901616 View in gBrowse