ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HK1
Approved Name	hexokinase 1
Location	10q22
Position	chr10:71029740-71161638, 1
External Links	HGNC: 4922 Entrez Gene: 3098 Ensembl: ENSG00000156515 UCSC: uc001jpi.4
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Neale BM, 2010 (b)	No significant or Trend associated SNP was mapped in this gene.	Non-significant

Gene related SNPs (count: 9)

Literature-origin SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs2394538	chr10:71033697(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/1/0)
rs2394534	chr10:71029302(Fwd)	downstream_gene_variant; upstream_gene_variant	1(0/1/0)
rs906219	chr10:71026510(Fwd)	downstream_gene_variant; intron_variant; missense_variant; nc_transcript_variant; upstream_gene_variant	1(0/1/0)

LD-proxies (count: 6)

rs_ID	Location	Functional Annotation
rs4746834	chr10:71041806(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs10762275	chr10:71040619(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs10998692	chr10:71041527(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs10823333	chr10:71052888(Fwd)	intron_variant; nc_transcript_variant
rs5030949	chr10:71038340(Fwd)	intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant
rs12218331	chr10:71049561(Fwd)	intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0055085	transmembrane transport	biological process	TAS	95
GO:0004396	hexokinase activity	molecular function	TAS[3207429]	1
GO:0005515	protein binding	molecular function	IPI	1015
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0005741	mitochondrial outer membrane	cellular component	IEA	22
GO:0001678	cellular glucose homeostasis	biological process	IBA	2
GO:0015758	glucose transport	biological process	TAS	14
GO:0005829	cytosol	cellular component	TAS	485
GO:0005524	ATP binding	molecular function	IEA	265
GO:0005730	nucleolus	cellular component	IDA	271
GO:0008865	fructokinase activity	molecular function	IBA	2
GO:0019158	mannokinase activity	molecular function	IBA	2
GO:0005739	mitochondrion	cellular component	IDA	221
GO:0004340	glucokinase activity	molecular function	IBA	2
GO:0005975	carbohydrate metabolic process	biological process	TAS	59
GO:0006096	glycolysis	biological process	IBA	4
GO:0051156	glucose 6-phosphate metabolic process	biological process	IBA	2
GO:0005634	nucleus	cellular component	IDA	877
GO:0045121	membrane raft	cellular component	IEA	24
GO:0008645	hexose transport	biological process	TAS	7

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene
hsa00530	Aminosugars metabolism	7
hsa00521	Streptomycin biosynthesis	1
hsa00051	Fructose and mannose metabolism	12
hsa00052	Galactose metabolism	2
hsa00500	Starch and sucrose metabolism	27

Genes shared at least 5 GO terms with HK1 (count: 23)

Gene Symbol	Pathway Count	Pathway List
HKDC1	11	cellular glucose homeostasis; cytosol; ATP binding; nucleolus; fructokinase activity; mannokinase activity; mitochondrion; glucokinase activity; glycolysis; glucose 6-phosphate metabolic process; nucleus;
NUPL2	7	transmembrane transport; small molecule metabolic process; glucose transport; cytosol; carbohydrate metabolic process; nucleus; hexose transport;
NUP160	7	transmembrane transport; protein binding; small molecule metabolic process; glucose transport; cytosol; carbohydrate metabolic process; hexose transport;
NUP62	6	transmembrane transport; protein binding; small molecule metabolic process; glucose transport; carbohydrate metabolic process; hexose transport;
STK11	6	protein binding; small molecule metabolic process; cytosol; ATP binding; mitochondrion; nucleus;
GSK3B	6	protein binding; cytosol; ATP binding; nucleolus; nucleus; membrane raft;
MAPK1	6	protein binding; cytosol; ATP binding; nucleolus; mitochondrion; nucleus;
MAPK3	6	protein binding; cytosol; ATP binding; nucleolus; mitochondrion; nucleus;
SLC37A4	5	transmembrane transport; small molecule metabolic process; glucose transport; carbohydrate metabolic process; hexose transport;
NUP155	5	transmembrane transport; small molecule metabolic process; glucose transport; carbohydrate metabolic process; hexose transport;
SLC2A3	5	transmembrane transport; small molecule metabolic process; glucose transport; carbohydrate metabolic process; hexose transport;
IARS	5	protein binding; cytosol; ATP binding; nucleolus; nucleus;
PMAIP1	5	protein binding; mitochondrial outer membrane; cytosol; mitochondrion; nucleus;
HSPA8	5	protein binding; cytosol; ATP binding; nucleolus; nucleus;
PPP1CA	5	protein binding; small molecule metabolic process; cytosol; nucleolus; nucleus;
GSTP1	5	protein binding; small molecule metabolic process; cytosol; mitochondrion; nucleus;
DCPS	5	protein binding; cytosol; nucleolus; mitochondrion; nucleus;
TH	5	protein binding; small molecule metabolic process; cytosol; mitochondrion; nucleus;
DDX23	5	protein binding; ATP binding; nucleolus; mitochondrion; nucleus;
ALDOB	5	protein binding; small molecule metabolic process; cytosol; carbohydrate metabolic process; glycolysis;
PSMC3	5	protein binding; small molecule metabolic process; cytosol; ATP binding; nucleus;
PRKD1	5	protein binding; small molecule metabolic process; cytosol; ATP binding; nucleus;
ACACA	5	protein binding; small molecule metabolic process; cytosol; ATP binding; mitochondrion;

Genes shared at least 2 KEGG pathways with HK1 (count: 1)

Gene Symbol	Pathway Count	Pathway List
MTMR2	2	Aminosugars metabolism; Fructose and mannose metabolism;

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Region: chr10:71029740..71161638 View in gBrowse