ADHDgene Database

SNP Report

Basic Info

Name	rs906219 dbSNP Ensembl
Location	Chr10:71026510(Fwd)
Variant Alleles	C/A
Ancestral Allele	C
Functional Annotation	downstream_gene_variant; intron_variant; missense_variant; nc_transcript_variant; upstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000395086) intron_variant(ENST00000413220; ENST00000486754) missense_variant(ENST00000354624) nc_transcript_variant(ENST00000413220; ENST00000486754) upstream_gene_variant(ENST00000464803; ENST00000450646; ENST00000480047; ENST00000479594; ENST00000483077; ENST00000476368; ENST00000360289; ENST00000448642)
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Neale BM, 2010 (b)	A:C		GLM P-value=3.73E-05, meta-analysis P-value=0.0368 GLM P-value=3.73E-05, meta-analysis P-value=0.0368	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
HK1	hexokinase 1	10q22	1(0/1/0)
HKDC1	hexokinase domain containing 1	10q22.1	1(0/1/0)

SNPs in LD with rs906219 (count: 5) View in gBrowse (chr10:71026510..71041806 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.


rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]
rs2394538	intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/1/0)	0.82[ASW]; 0.946[CEU]; 0.907[CHB]; 0.951[CHD]; 0.905[GIH]; 0.904[JPT]; 0.957[MEX]; 0.814[MKK]; 0.839[TSI]; 1.0[YRI]

rs_ID	Functional Annotation	r²[population]
rs10998692	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CHB]; 0.852[JPT]; 0.9[YRI]
rs5030949	intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	1.0[CHB]; 0.928[CHD]; 0.905[GIH]; 0.952[JPT]; 0.957[MEX]; 0.814[MKK]; 1.0[YRI]
rs4746834	intron_variant; nc_transcript_variant; upstream_gene_variant	0.942[MKK]
rs10762275	intron_variant; nc_transcript_variant; upstream_gene_variant	0.943[MKK]