ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Study Report

Basic Info

Reference	Neale BM, 2010 (b)20732627
Citation	Neale B. M., Medland S., Ripke S., Anney R. J., Asherson P., Buitelaar J., Franke B., Gill M., Kent L., Holmans P., Middleton F., Thapar A., Lesch K. P., Faraone S. V., Daly M., Nguyen T. T., Schafer H., Steinhausen H. C., Reif A., Renner T. J., Romanos M., Romanos J., Warnke A., Walitza S., Freitag C., Meyer J., Palmason H., Rothenberger A., Hawi Z., Sergeant J., Roeyers H., Mick E. and Biederman J. (2010) "Case-control genome-wide association study of attention-deficit/hyperactivity disorder." J Am Acad Child Adolesc Psychiatry, 49(9): 906-20.
Study Design	case-control
Study Type	GWAS
Sample Size	1,150 cases and 2,653 controls
Predominant Ethnicity	Caucasian
Population	United Kingdom, Ireland, Germany, the Netherlands, USA
Gender	730(84%) males
Age Group	Children/Adolescents : aged 5-17, mean age 10.5 years (SD=2.9) in case sample

Detail Info

Summary	They used case-control analyses of 896 cases with DSM-IV ADHD genotyped using the Affymetrix 5.0 array and 2,455 repository controls screened for psychotic and bipolar symptoms genotyped using Affymetrix 6.0 arrays. A consensus SNP set was imputed using BEAGLE 3.0, resulting in an analysis dataset of 1,033,244 SNPs. Data were analyzed using a generalized linear model. No genomewide significant associations were found. The most significant results implicated the following genes: PRKG1, FLNC, TCERG1L, PPM1H, NXPH1, PPM1H, CDH13, HK1, and HKDC1.
Total Sample	In total, there are 1,150 cases and 2,653 controls. After QC, 896 cases and 2455 controls were used for analysis.
Sample Collection	The cases used in this analysis consist of (a) samples collected by a subset of the International Multicenter ADHD Genetics (IMAGE) Project sites but not included in the IMAGE GWAS; and (b) samples collected at additional sites (Frankfurt/Homburg, Trier, Wuerzburg, Germany, Scotland, and Cardiff, United Kingdom) that were assessed in a manner similar to IMAGE samples. They were predominantly of European origin from the United Kingdom, Ireland, Germany, the Netherlands, and the United States.
Diagnosis Description	Cases were identified mainly through outpatient clinics at the data collection sites. Of the cases, 81% met criteria for DSM-IV ADHD. Children had been referred for assessment of hyperactive, disruptive or disorganized behavior and had been clinically diagnosed as ADHD (or hyperkinetic disorder, the most closely equivalent category in the ICD-10 nomenclature used at some of the clinics). Clinical and demographic features of the case sample stratified by site are provided in original publication. For detailed information, please refer to the original publication.
Technique	Cases were genotyped using the Affymetrix 5.0 array at the State University of New York Upstate Medical University, Syracuse using the standard protocol issued by Affymetrix. The genotypes were called using both BRLMM-P and BIRDSUITE, with any calling discrepancies coded as missing. Controls were genotyped using the Affymetrix 6.0 array, at the Broad Institute National Center for Genotyping and Analysis. Genotype calls were made with the BIRDSEED program, a module of the BIRDSUITE package. The control genotype data initially quality controlled by the National Center for Biotechnology Information (NCBI). Please refer to original publication for the details of quality control.
Analysis Method	After the QC, they conducted association analysis using a generalized linear model (GLM) in R, using the 10 principal components from the MDS procedure as covariates. The P-value reported is the Wald statistic from the GLM, which is asymptotically distributed as a chi-square with 1 degree of freedom under the null hypothesis.
Result Description	None of the SNPs achieved genome-wide significance (P-value<5.0e-08), either in the sample reported here or in a meta-analysis or our results with other samples. However several of their top findings deserve further comment.

SNPs reported by this study (count: 100)

SNP	Allele Change	Statistical Values	Author Comments	Result of Statistical Analysis
rs1021055	A:G	GLM P-value=1.27E-05, meta-analysis P-value=0.1103	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs10506445	A:G	GLM P-value=1.44E-05, meta-analysis P-value=0.0199	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs10498690	A:G	GLM P-value=2.80E-05, meta-analysis P-value=0.3496	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs10762539	T:G	GLM P-value=3.24E-05, meta-analysis P-value=0.1289	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs10762524	T:G	GLM P-value=9.89E-07, meta-analysis P-value=0.3336	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs10258145	A:G	GLM P-value=3.58E-05, meta-analysis P-value=0.3281	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs1023556	T:C	GLM P-value=2.61E-05, meta-analysis P-value=0.4215	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs10490827	T:C	GLM P-value=4.48E-06, meta-analysis P-value=0.01823	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs10456831	T:C	GLM P-value=3.74E-05, meta-analysis P-value=0.5029	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs10895454	A:C	GLM P-value=3.61E-05, meta-analysis P-value=0.1831	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs10895458	A:C	GLM P-value=2.81E-05, meta-analysis P-value=0.009655	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs10823978	A:G	GLM P-value=3.51E-05, meta-analysis P-value=0.02782	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs10895437	A:G	GLM P-value=2.22E-05, meta-analysis P-value=0.712	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs10823964	T:G	GLM P-value=7.84E-07, meta-analysis P-value=0.2744	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs10823973	C:G	GLM P-value=6.32E-07, meta-analysis P-value=0.3663	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs10762540	A:C	GLM P-value=3.62E-05, meta-analysis P-value=0.1287	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs10823954	A:G	GLM P-value=3.01E-05, meta-analysis P-value=0.02442	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs11853869	T:C	GLM P-value=1.97E-05, meta-analysis P-value=0.34	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs12317552	T:C	GLM P-value=9.14E-06, meta-analysis P-value=0.005663	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs11625217	A:G	GLM P-value=2.71E-05, meta-analysis P-value=0.05322	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs11731185	A:C	GLM P-value=4.09E-06, meta-analysis P-value=0.03243	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs11239157	T:C	GLM P-value=1.52E-05, meta-analysis P-value=0.1195	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs11593241	T:C	GLM P-value=5.73E-06, meta-analysis P-value=0.06239	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs10900075	T:C	GLM P-value=1.50E-05, meta-analysis P-value=0.1204	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs11117283	T:C	GLM P-value=1.15E-05, meta-analysis P-value=0.005478	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs13238831	T:C	GLM P-value=5.57E-06, meta-analysis P-value=0.0005903	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs13227216	T:C	GLM P-value=2.90E-05, meta-analysis P-value=0.1392	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs1278776	A:G	GLM P-value=2.85E-05, meta-analysis P-value=0.0000285	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs12690808	T:G	GLM P-value=3.72E-05, meta-analysis P-value=0.3395	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs12633370	A:G	GLM P-value=5.03E-06, meta-analysis P-value=0.01686	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs12631899	T:C	GLM P-value=2.98E-05, meta-analysis P-value=0.03321	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs12631326	T:C	GLM P-value=1.14E-05, meta-analysis P-value=0.01534	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs12432593	A:C	GLM P-value=3.00E-05, meta-analysis P-value=0.07092	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs1583670	T:C	GLM P-value=1.94E-05, meta-analysis P-value=0.1733	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs1524174	A:C	GLM P-value=2.47E-05, meta-analysis P-value=0.009319	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs1481964	A:G	GLM P-value=2.49E-05, meta-analysis P-value=0.1488	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs1481963	A:G	GLM P-value=1.78E-05, meta-analysis P-value=0.8727	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs1481961	A:C	GLM P-value=3.36E-05, meta-analysis P-value=0.1996	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs1370868	A:G	GLM P-value=1.07E-05, meta-analysis P-value=0.2392	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs1326022	A:G	GLM P-value=1.64E-05, meta-analysis P-value=0.1636	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs1326021	T:C	GLM P-value=1.55E-05, meta-analysis P-value=0.1755	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs1999774	A:T	GLM P-value=1.25E-05, meta-analysis P-value=0.1014	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs1980818	C:G	GLM P-value=1.37E-05, meta-analysis P-value=0.2628	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs2061971	A:G	GLM P-value=2.42E-05, meta-analysis P-value=0.06829	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs2033791	A:G	GLM P-value=7.66E-06, meta-analysis P-value=0.1028	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs2291560	T:C	GLM P-value=3.21E-05, meta-analysis P-value=0.002541	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs2107281	T:C	GLM P-value=1.19E-05, meta-analysis P-value=0.05902	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs2394534	T:G	GLM P-value=1.04E-05, meta-analysis P-value=0.02563	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs2291567	T:C	GLM P-value=1.97E-06, meta-analysis P-value=0.04204	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs17095690	A:G	GLM P-value=1.65E-05, meta-analysis P-value=0.256	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs16855659	T:C	GLM P-value=1.28E-05, meta-analysis P-value=0.01951	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs17495366	T:C	GLM P-value=3.12E-05, meta-analysis P-value=0.01472	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs17151821	C:G	GLM P-value=1.05E-05, meta-analysis P-value=0.014	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs1903960	T:G	GLM P-value=1.24E-05, meta-analysis P-value=0.03183	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs17729098	T:C	GLM P-value=1.68E-06, meta-analysis P-value=0.00000168	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs1903979	T:C	GLM P-value=1.21E-05, meta-analysis P-value=0.1637	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs1903977	A:T	GLM P-value=1.50E-05, meta-analysis P-value=0.1749	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs4624074	T:C	GLM P-value=3.10E-05, meta-analysis P-value=0.04751	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs490618	A:T	GLM P-value=1.32E-05, meta-analysis P-value=0.2535	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs532347	A:G	GLM P-value=1.26E-05, meta-analysis P-value=0.2679	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs536700	C:G	GLM P-value=1.42E-05, meta-analysis P-value=0.2551	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs545245	T:C	GLM P-value=3.24E-05, meta-analysis P-value=0.0188	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs556372	T:C	GLM P-value=3.59E-05, meta-analysis P-value=0.01625	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs567621	T:C	GLM P-value=1.25E-05, meta-analysis P-value=0.3004	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs6014657	A:C	GLM P-value=5.25E-06, meta-analysis P-value=0.2581	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs2394538	T:C	GLM P-value=2.77E-05, meta-analysis P-value=0.03182	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs2397752	T:C	GLM P-value=1.33E-05, meta-analysis P-value=0.4843	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs2796304	A:C	GLM P-value=3.65E-05, meta-analysis P-value=0.09506	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs2893482	A:G	GLM P-value=3.01E-05, meta-analysis P-value=0.2577	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs36936	T:C	GLM P-value=3.36E-05, meta-analysis P-value=0.0002923	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs3734973	A:G	GLM P-value=2.97E-06, meta-analysis P-value=0.0661	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs4374483	A:G	GLM P-value=3.57E-05, meta-analysis P-value=0.07212	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs4488454	C:G	GLM P-value=4.97E-06, meta-analysis P-value=0.003164	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs7117196	T:C	GLM P-value=1.64E-05, meta-analysis P-value=0.3623	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs7105630	T:C	GLM P-value=2.04E-05, meta-analysis P-value=0.9765	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs7092969	A:T	GLM P-value=2.57E-06, meta-analysis P-value=0.05565	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs7083920	T:C	GLM P-value=1.80E-05, meta-analysis P-value=0.1134	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs716274	A:G	GLM P-value=8.67E-06, meta-analysis P-value=0.01452	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs716273	T:C	GLM P-value=8.98E-06, meta-analysis P-value=0.01426	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs7146388	A:G	GLM P-value=1.85E-05, meta-analysis P-value=0.2889	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs7140723	A:C	GLM P-value=3.27E-05, meta-analysis P-value=0.7938	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs6424669	C:G	GLM P-value=1.60E-05, meta-analysis P-value=0.05057	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs6064362	A:G	GLM P-value=2.00E-05, meta-analysis P-value=0.1074	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs6064361	T:C	GLM P-value=2.20E-05, meta-analysis P-value=0.1339	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs6014664	T:C	GLM P-value=7.38E-06, meta-analysis P-value=0.2728	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs7069381	T:G	GLM P-value=1.50E-05, meta-analysis P-value=0.1185	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs6986709	T:C	GLM P-value=2.12E-05, meta-analysis P-value=0.02959	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs6672282	A:G	GLM P-value=5.49E-06, meta-analysis P-value=0.01273	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Trend
rs6462569	T:C	GLM P-value=3.40E-05, meta-analysis P-value=0.2659	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs932792	A:C	GLM P-value=3.22E-05, meta-analysis P-value=0.1638	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs906219	A:C	GLM P-value=3.73E-05, meta-analysis P-value=0.0368	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs913000	T:C	GLM P-value=3.34E-05, meta-analysis P-value=0.1422	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs7893146	T:C	GLM P-value=2.87E-05, meta-analysis P-value=0.02307	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs7901487	T:C	GLM P-value=3.42E-05, meta-analysis P-value=0.1268	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs7543390	A:C	GLM P-value=1.06E-05, meta-analysis P-value=0.1833	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs7633167	A:C	GLM P-value=1.49E-05, meta-analysis P-value=0.04074	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs8045006	A:C	GLM P-value=2.28E-05, meta-analysis P-value=0.000158	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs899889	A:G	GLM P-value=1.32E-05, meta-analysis P-value=0.1055	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs8005625	T:G	GLM P-value=3.24E-05, meta-analysis P-value=0.6327	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant
rs8011986	T:C	GLM P-value=1.40E-05, meta-analysis P-value=0.2581	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant

Genes reported by this study (count: 11)

Gene	Statistical Values/Author Comments	Result of Statistical Analysis
PRKG1	Trend associated SNP was mapped in this gene. Trend associated SNP was mapped in this gene.	Trend
ATP11A	No significant or Trend associated SNP was mapped in this ge...... No significant or Trend associated SNP was mapped in this gene. More...	Non-significant
HK1	No significant or Trend associated SNP was mapped in this ge...... No significant or Trend associated SNP was mapped in this gene. More...	Non-significant
HKDC1	No significant or Trend associated SNP was mapped in this ge...... No significant or Trend associated SNP was mapped in this gene. More...	Non-significant
CDH13	No significant or Trend associated SNP was mapped in this ge...... No significant or Trend associated SNP was mapped in this gene. More...	Non-significant
TCERG1L	Trend associated SNP was mapped in this gene. Trend associated SNP was mapped in this gene.	Trend
PPM1H	Trend associated SNP was mapped in this gene. Trend associated SNP was mapped in this gene.	Trend
NRXN1	No significant or Trend associated SNP was mapped in this ge...... No significant or Trend associated SNP was mapped in this gene. More...	Non-significant
FLNC	Trend associated SNP was mapped in this gene. Trend associated SNP was mapped in this gene.	Trend
C1orf173	No significant or Trend associated SNP was mapped in this ge...... No significant or Trend associated SNP was mapped in this gene. More...	Non-significant
NXPH1	No significant or Trend associated SNP was mapped in this ge...... No significant or Trend associated SNP was mapped in this gene. More...	Non-significant