ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CDH13
Symbol Alias	CDHH
Approved Name	cadherin 13, H-cadherin (heart)
Name Alias	T-cadherin
Location	16q23.3
Position	chr16:82660578-83830204, +
External Links	HGNC: 1753 Entrez Gene: 1012 Ensembl: ENSG00000140945 UCSC: uc002fgx.2
No. of Studies	3 (significant: 1; non-significant: 1; trend: 1)
Source	Literature-origin; Mapped by CNV; Mapped by LD-proxy; Mapped by literature SNP; Mapped by significant region

Gene related studies (count: 3)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Neale BM, 2010 (b)	No significant or Trend associated SNP was mapped in this gene.	Non-significant
Lasky-Su J, 2008	rs6565113 in in this gene was significant within a phenotype.	Significant
Lesch KP, 2008	Trend associated SNP was mapped in this gene.	Trend

Gene related SNPs (count: 34)

Literature-origin SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs11646411	Chr16:82746937(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant	1(0/0/1)
rs6565113	Chr16:83107646(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant	1(1/0/0)
rs8045006	Chr16:83256273(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant	1(0/1/0)

LD-proxies (count: 31)

rs_ID	Location	Functional Annotation
rs3935908	Chr16:83106301(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs8061985	Chr16:83109108(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs8059052	Chr16:83107505(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs9932437	Chr16:83112996(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs7192356	Chr16:83111317(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs4783321	Chr16:83110116(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs6565114	Chr16:83114167(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs6565115	Chr16:83117017(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs7499448	Chr16:83111996(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs7187580	Chr16:83119591(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs4238726	Chr16:83117722(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs7201707	Chr16:83121550(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs12929239	Chr16:83128114(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs12929690	Chr16:83136478(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs12924791	Chr16:83135616(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs750145	Chr16:83259167(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs4564551	Chr16:83246660(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs10514587	Chr16:83256377(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs12325628	Chr16:83255317(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs11647463	Chr16:83254361(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs11150550	Chr16:83253759(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs12716966	Chr16:83253620(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs11864551	Chr16:83253433(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs889730	Chr16:83257305(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs11150553	Chr16:83258217(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs8182163	Chr16:83258017(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs7185268	Chr16:83256828(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs7185229	Chr16:83256768(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs11646944	Chr16:83256636(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs11646932	Chr16:83256566(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs11640229	Chr16:83256529(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_36	chr16:82208011-82797605 (NCBI36 / hg18)	589595	16q23.3-16q24.1	dup

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16q23.1-24.3	chr16:74100000-90354753	1 (1/0/0)

Gene related GO terms (count: 35)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 35)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005509	calcium ion binding	Molecular Function		124
GO:0002040	sprouting angiogenesis	Biological Process	IDA[16873731]	4
GO:0001954	positive regulation of cell-matrix adhesion	Biological Process	IMP[17573778]	3
GO:0001938	positive regulation of endothelial cell proliferation	Biological Process	IMP[15364621]	8
GO:0005901	caveola	Cellular Component	IDA[9650591]	12
GO:0005886	plasma membrane	Cellular Component	IDA[10737605]	772
GO:0005737	cytoplasm	Cellular Component	IDA[10737605]	690
GO:0005615	extracellular space	Cellular Component	IDA[16873731]	126
GO:0016339	calcium-dependent cell-cell adhesion	Biological Process	IDA[10601632]	8
GO:0016601	Rac protein signal transduction	Biological Process	IMP[15703273]	1
GO:0030032	lamellipodium assembly	Biological Process	IDA[15703273]	8
GO:0030100	regulation of endocytosis	Biological Process	IMP[17573778]	3
GO:0007156	homophilic cell adhesion	Biological Process	IDA[10601632]	27
GO:0007162	negative regulation of cell adhesion	Biological Process	IDA[14729458]	6
GO:0007266	Rho protein signal transduction	Biological Process	IMP[15703273]	11
GO:0008285	negative regulation of cell proliferation	Biological Process	IDA[10737605]	59
GO:0034332	adherens junction organization	Biological Process		9
GO:0042058	regulation of epidermal growth factor receptor signaling pathway	Biological Process	IMP[17573778]	1
GO:0043005	neuron projection	Cellular Component	IDA[10737605]	35
GO:0043542	endothelial cell migration	Biological Process	IDA[14729458]	2
GO:0030169	low-density lipoprotein particle binding	Molecular Function	IDA[16013438]	5
GO:0030335	positive regulation of cell migration	Biological Process	IDA[14729458]	29
GO:0031225	anchored to membrane	Cellular Component		29
GO:0034329	cell junction assembly	Biological Process		13
GO:0050850	positive regulation of calcium-mediated signaling	Biological Process	IDA[16013438]	7
GO:0048661	positive regulation of smooth muscle cell proliferation	Biological Process	IMP[15364621]	5
GO:0051668	localization within membrane	Biological Process	IMP[17573778]	2
GO:0050927	positive regulation of positive chemotaxis	Biological Process	IDA[16013438]	3
GO:0045216	cell-cell junction organization	Biological Process		10
GO:0043616	keratinocyte proliferation	Biological Process	IDA[15816843]	4
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IMP[16099944]	131
GO:0045296	cadherin binding	Molecular Function	IDA[10601632]	9
GO:0055100	adiponectin binding	Molecular Function		1
GO:0055096	low-density lipoprotein particle mediated signaling	Biological Process	IDA[16013438]	1
GO:0071813	lipoprotein particle binding	Molecular Function	IDA[11027617]	2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with CDH13 (count: 13)

Gene Symbol	Pathway Count	Pathway List
CDH15	7	calcium ion binding; caveola; plasma membrane; homophilic cell adhesion; adherens junction organization; cell junction assembly; cell-cell junction organization;
CDH2	7	calcium ion binding; plasma membrane; calcium-dependent cell-cell adhesion; homophilic cell adhesion; adherens junction organization; cell junction assembly; cell-cell junction organization;
CDH6	7	calcium ion binding; plasma membrane; cytoplasm; homophilic cell adhesion; adherens junction organization; cell junction assembly; cell-cell junction organization;
CDH12	6	calcium ion binding; plasma membrane; homophilic cell adhesion; adherens junction organization; cell junction assembly; cell-cell junction organization;
CDH4	6	calcium ion binding; plasma membrane; homophilic cell adhesion; adherens junction organization; cell junction assembly; cell-cell junction organization;
VEGFA	6	positive regulation of endothelial cell proliferation; cytoplasm; extracellular space; positive regulation of cell migration; positive regulation of positive chemotaxis; positive regulation of transcription from RNA polymerase II promoter;
CTNND1	6	plasma membrane; cytoplasm; adherens junction organization; cell junction assembly; cell-cell junction organization; cadherin binding;
F7	5	calcium ion binding; plasma membrane; extracellular space; positive regulation of cell migration; positive regulation of positive chemotaxis;
ILK	5	positive regulation of cell-matrix adhesion; plasma membrane; cytoplasm; positive regulation of cell migration; cell junction assembly;
APC	5	plasma membrane; cytoplasm; negative regulation of cell proliferation; positive regulation of cell migration; cadherin binding;
CADM1	5	plasma membrane; homophilic cell adhesion; adherens junction organization; cell junction assembly; cell-cell junction organization;
FGF10	5	plasma membrane; extracellular space; negative regulation of cell proliferation; keratinocyte proliferation; positive regulation of transcription from RNA polymerase II promoter;
PVRL1	5	plasma membrane; homophilic cell adhesion; adherens junction organization; cell junction assembly; cell-cell junction organization;

Genes shared at least 2 KEGG pathways with CDH13 (count: 0)

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Region: chr16:82660578..83830204 View in gBrowse