ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	VEGFA
Previous Symbol	VEGF
Symbol Alias	VEGF-A, VPF
Approved Name	vascular endothelial growth factor A
Previous Name	"vascular endothelial growth factor"
Location	6p12
Position	chr6:43737921-43754224, 1
External Links	HGNC: 12680 Entrez Gene: 7422 Ensembl: ENSG00000112715 UCSC: uc003owh.3
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Hinney, A., 2011	This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08.	Non-significant

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs6458351	chr6:43791080(Fwd)		1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 113)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 113)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0031093	platelet alpha granule lumen	cellular component	TAS	5
GO:0051894	positive regulation of focal adhesion assembly	biological process	IDA[16489009]	4
GO:0051781	positive regulation of cell division	biological process	IEA	12
GO:1901727	positive regulation of histone deacetylase activity	biological process	IDA	2
GO:1900745	positive regulation of p38MAPK cascade	biological process	IDA[18386220]	1
GO:0042462	eye photoreceptor cell development	biological process	ISS	3
GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	biological process	IDA	2
GO:0007596	blood coagulation	biological process	TAS	85
GO:0048018	receptor agonist activity	molecular function	IPI	2
GO:0042803	protein homodimerization activity	molecular function	ISS	128
GO:0001570	vasculogenesis	biological process	TAS[15015550]	10
GO:0005576	extracellular region	cellular component	TAS	267
GO:0060948	cardiac vascular smooth muscle cell development	biological process	ISS	2
GO:0003169	coronary vein morphogenesis	biological process	ISS	1
GO:0048754	branching morphogenesis of a tube	biological process	ISS	7
GO:0030324	lung development	biological process	ISS	12
GO:0048593	camera-type eye morphogenesis	biological process	ISS	2
GO:0030225	macrophage differentiation	biological process	IDA	2
GO:0043183	vascular endothelial growth factor receptor 1 binding	molecular function	IPI[1312256]	2
GO:0050927	positive regulation of positive chemotaxis	biological process	IDA[12744932]	3
GO:0007498	mesoderm development	biological process	ISS	9
GO:0050679	positive regulation of epithelial cell proliferation	biological process	ISS	10
GO:0030141	secretory granule	cellular component	IDA[17082651]	17
GO:0060754	positive regulation of mast cell chemotaxis	biological process	IDA[19275959]	2
GO:0016020	membrane	cellular component	IEA	155
GO:0090037	positive regulation of protein kinase C signaling cascade	biological process	IDA[18059339]	6
GO:0046982	protein heterodimerization activity	molecular function	IDA[8702615]	73
GO:0036303	lymph vessel morphogenesis	biological process	ISS	1
GO:0040007	growth	biological process	ISS	4
GO:0003007	heart morphogenesis	biological process	ISS	6
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	biological process	IDA	2
GO:0060319	primitive erythrocyte differentiation	biological process	ISS	2
GO:0035924	cellular response to vascular endothelial growth factor stimulus	biological process	IDA[18440775]	3
GO:0008201	heparin binding	molecular function	IDA[15001987]; IMP[14570917]	28
GO:0045766	positive regulation of angiogenesis	biological process	IDA; IMP[18275976]	11
GO:0050918	positive chemotaxis	biological process	IDA[19275959]	8
GO:0002052	positive regulation of neuroblast proliferation	biological process	ISS	5
GO:0005615	extracellular space	cellular component	IDA[9202027]; ISS	133
GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	biological process	IDA[17470632]	1
GO:0005737	cytoplasm	cellular component	IDA[17082651]	781
GO:0030855	epithelial cell differentiation	biological process	ISS	7
GO:0031954	positive regulation of protein autophosphorylation	biological process	IDA	4
GO:0009986	cell surface	cellular component	IDA[17470632]	75
GO:0060982	coronary artery morphogenesis	biological process	ISS	2
GO:0048010	vascular endothelial growth factor receptor signaling pathway	biological process	IDA; TAS	6
GO:0001968	fibronectin binding	molecular function	IDA[14570917]	3
GO:0001934	positive regulation of protein phosphorylation	biological process	IDA[18386220]	24
GO:0007595	lactation	biological process	ISS	7
GO:0001938	positive regulation of endothelial cell proliferation	biological process	IDA[10022831]; ISS	8
GO:0071456	cellular response to hypoxia	biological process	IDA[10575000]; TAS	14
GO:0002042	cell migration involved in sprouting angiogenesis	biological process	IDA	2
GO:0030168	platelet activation	biological process	TAS	38
GO:0043536	positive regulation of blood vessel endothelial cell migration	biological process	IDA	3
GO:0008083	growth factor activity	molecular function	IDA; ISS	28
GO:0030224	monocyte differentiation	biological process	IDA	3
GO:0001541	ovarian follicle development	biological process	ISS	4
GO:0010628	positive regulation of gene expression	biological process	IDA[18386220]	29
GO:0002687	positive regulation of leukocyte migration	biological process	TAS[1312256]	1
GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	biological process	IDA	2
GO:0043498	cell surface binding	molecular function	IDA[17470632]	3
GO:0043117	positive regulation of vascular permeability	biological process	IDA[16109918]	4
GO:0048469	cell maturation	biological process	ISS	7
GO:0003151	outflow tract morphogenesis	biological process	ISS	11
GO:0048739	cardiac muscle fiber development	biological process	ISS	3
GO:0035767	endothelial cell chemotaxis	biological process	IDA[18440775]	1
GO:0031077	post-embryonic camera-type eye development	biological process	ISS	2
GO:0043184	vascular endothelial growth factor receptor 2 binding	molecular function	IPI	2
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	IMP[18093989]	46
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	biological process	ISS	6
GO:0010740	positive regulation of intracellular protein kinase cascade	biological process	IDA	2
GO:0032147	activation of protein kinase activity	biological process	IDA[18059339]	6
GO:0005172	vascular endothelial growth factor receptor binding	molecular function	IPI[10471394]	1
GO:0005161	platelet-derived growth factor receptor binding	molecular function	IPI[17470632]	2
GO:0008284	positive regulation of cell proliferation	biological process	IDA[7929439]	75
GO:0042056	chemoattractant activity	molecular function	IDA	5
GO:0060749	mammary gland alveolus development	biological process	ISS	5
GO:0005515	protein binding	molecular function	IPI	1015
GO:0043066	negative regulation of apoptotic process	biological process	IMP[10066377]	85
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[18093989]	90
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	biological process	TAS	7
GO:0005578	proteinaceous extracellular matrix	cellular component	NAS[14570917]	51
GO:0002576	platelet degranulation	biological process	TAS	11
GO:0005125	cytokine activity	molecular function	IDA[18440775]; ISS	20
GO:0043129	surfactant homeostasis	biological process	ISS	3
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	IDA[18386220]	12
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[18093989]; IMP[18093989]	141
GO:0001525	angiogenesis	biological process	IDA[11427521]	38
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	biological process	IDA[10022831]	15
GO:0001701	in utero embryonic development	biological process	ISS	39
GO:0033138	positive regulation of peptidyl-serine phosphorylation	biological process	IDA	11
GO:0031334	positive regulation of protein complex assembly	biological process	IDA[16489009]	4
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	biological process	IDA[7929439]	5
GO:0033554	cellular response to stress	biological process	TAS	14
GO:0048844	artery morphogenesis	biological process	ISS	9
GO:0043406	positive regulation of MAP kinase activity	biological process	IDA[18440775]	10
GO:0001666	response to hypoxia	biological process	IDA[16490744]	41
GO:0051272	positive regulation of cellular component movement	biological process	IDA[10527820]	5
GO:0071542	dopaminergic neuron differentiation	biological process	ISS	3
GO:0001822	kidney development	biological process	ISS	17
GO:0042802	identical protein binding	molecular function	IPI	77
GO:0045785	positive regulation of cell adhesion	biological process	IDA[19674970]	7
GO:0002053	positive regulation of mesenchymal cell proliferation	biological process	ISS	9
GO:0050930	induction of positive chemotaxis	biological process	IDA[19275959]; NAS[12744932]	6
GO:0032793	positive regulation of CREB transcription factor activity	biological process	IDA	6
GO:0002092	positive regulation of receptor internalization	biological process	IDA	7
GO:0008360	regulation of cell shape	biological process	IDA[10527820]	21
GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	biological process	IMP[19652095]	1
GO:0007399	nervous system development	biological process	TAS[15351965]	60
GO:0002575	basophil chemotaxis	biological process	IDA[17082651]	1
GO:0001569	patterning of blood vessels	biological process	ISS	8
GO:0010595	positive regulation of endothelial cell migration	biological process	IDA	7
GO:0030335	positive regulation of cell migration	biological process	IDA[7929439]	28
GO:0050840	extracellular matrix binding	molecular function	IC[14570917]	3

Gene related KEGG pathways (count: 7)

ID	Name	No. of Genes in ADHDgene
hsa04370	VEGF signaling pathway	18
hsa05219	Bladder cancer	7
hsa04510	Focal adhesion	40
hsa05211	Renal cell carcinoma	15
hsa04150	mTOR signaling pathway	15
hsa04060	Cytokine-cytokine receptor interaction	39
hsa05212	Pancreatic cancer	13

Genes shared at least 5 GO terms with VEGFA (count: 130)

Gene Symbol	Pathway Count	Pathway List
VEGFB	25	platelet alpha granule lumen; positive regulation of cell division; blood coagulation; protein homodimerization activity; extracellular region; vascular endothelial growth factor receptor 1 binding; positive regulation of mast cell chemotaxis; membrane; protein heterodimerization activity; heparin binding; positive chemotaxis; extracellular space; vascular endothelial growth factor receptor signaling pathway; positive regulation of endothelial cell proliferation; platelet activation; growth factor activity; positive regulation of vascular permeability; chemoattractant activity; protein binding; negative regulation of apoptotic process; platelet degranulation; angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; induction of positive chemotaxis;
PRKD1	15	positive regulation of histone deacetylase activity; cellular response to vascular endothelial growth factor stimulus; positive regulation of angiogenesis; cytoplasm; vascular endothelial growth factor receptor signaling pathway; positive regulation of endothelial cell proliferation; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; protein binding; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; positive regulation of peptidyl-serine phosphorylation; identical protein binding; positive regulation of CREB transcription factor activity; positive regulation of endothelial cell migration;
FGF10	15	extracellular region; branching morphogenesis of a tube; positive regulation of epithelial cell proliferation; heparin binding; positive chemotaxis; extracellular space; cell surface; growth factor activity; chemoattractant activity; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; induction of positive chemotaxis;
TBX1	14	protein homodimerization activity; mesoderm development; positive regulation of epithelial cell proliferation; heart morphogenesis; epithelial cell differentiation; coronary artery morphogenesis; positive regulation of protein phosphorylation; outflow tract morphogenesis; regulation of transcription from RNA polymerase II promoter; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; artery morphogenesis; positive regulation of mesenchymal cell proliferation;
GREM1	13	positive regulation of peptidyl-tyrosine autophosphorylation; receptor agonist activity; positive regulation of angiogenesis; extracellular space; cell surface; cell migration involved in sprouting angiogenesis; vascular endothelial growth factor receptor 2 binding; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of cell proliferation; protein binding; cytokine activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of receptor internalization;
MIF	13	extracellular region; positive chemotaxis; extracellular space; cytoplasm; cell surface; cell surface binding; chemoattractant activity; protein binding; negative regulation of apoptotic process; cytokine activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of peptidyl-serine phosphorylation; positive regulation of MAP kinase activity;
IL6	13	extracellular region; positive regulation of epithelial cell proliferation; extracellular space; platelet activation; growth factor activity; positive regulation of cell proliferation; negative regulation of apoptotic process; cytokine activity; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of peptidyl-serine phosphorylation; regulation of cell shape;
FGF9	12	positive regulation of cell division; extracellular region; positive regulation of epithelial cell proliferation; heparin binding; extracellular space; cytoplasm; growth factor activity; positive regulation of gene expression; positive regulation of cell proliferation; angiogenesis; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of mesenchymal cell proliferation;
NTF3	12	extracellular region; positive chemotaxis; growth factor activity; positive regulation of cell proliferation; chemoattractant activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of peptidyl-serine phosphorylation; induction of positive chemotaxis; positive regulation of receptor internalization; nervous system development; positive regulation of cell migration;
FN1	11	platelet alpha granule lumen; blood coagulation; extracellular region; heparin binding; extracellular space; platelet activation; protein binding; proteinaceous extracellular matrix; platelet degranulation; angiogenesis; regulation of cell shape;
HES1	11	protein homodimerization activity; lung development; cytoplasm; cell maturation; outflow tract morphogenesis; positive regulation of cell proliferation; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; artery morphogenesis; nervous system development;
CTGF	11	extracellular region; lung development; heparin binding; extracellular space; fibronectin binding; positive regulation of protein phosphorylation; growth factor activity; positive regulation of gene expression; positive regulation of cell proliferation; proteinaceous extracellular matrix; angiogenesis;
FLT4	11	extracellular region; positive regulation of protein kinase C signaling cascade; cellular response to vascular endothelial growth factor stimulus; cytoplasm; vascular endothelial growth factor receptor signaling pathway; positive regulation of protein phosphorylation; positive regulation of endothelial cell proliferation; positive regulation of cell proliferation; protein binding; negative regulation of apoptotic process; positive regulation of endothelial cell migration;
ADRA2A	10	blood coagulation; protein homodimerization activity; protein heterodimerization activity; cytoplasm; platelet activation; activation of protein kinase activity; positive regulation of cell proliferation; protein binding; positive regulation of MAP kinase activity; positive regulation of cell migration;
IL12B	10	protein homodimerization activity; membrane; protein heterodimerization activity; extracellular space; cytoplasm; growth factor activity; protein binding; cytokine activity; identical protein binding; positive regulation of cell adhesion;
FOXC2	10	vasculogenesis; mesoderm development; positive regulation of cell migration involved in sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; artery morphogenesis; patterning of blood vessels; positive regulation of endothelial cell migration;
TFAP2B	9	protein homodimerization activity; protein heterodimerization activity; positive regulation of cell proliferation; protein binding; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of transcription from RNA polymerase II promoter; kidney development;
INS	9	extracellular region; secretory granule; extracellular space; positive regulation of protein autophosphorylation; positive regulation of cell proliferation; protein binding; negative regulation of apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of cell migration;
WNT11	9	positive regulation of protein kinase C signaling cascade; extracellular space; cytoplasm; positive regulation of gene expression; outflow tract morphogenesis; negative regulation of apoptotic process; proteinaceous extracellular matrix; artery morphogenesis; positive regulation of cell migration;
PTPRJ	8	positive regulation of focal adhesion assembly; blood coagulation; vasculogenesis; positive chemotaxis; cell surface; platelet-derived growth factor receptor binding; protein binding; positive regulation of cell adhesion;
FGF4	8	positive regulation of cell division; extracellular region; heparin binding; positive regulation of protein phosphorylation; growth factor activity; positive regulation of cell proliferation; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
IGF2	8	positive regulation of cell division; extracellular region; extracellular space; positive regulation of protein phosphorylation; growth factor activity; positive regulation of cell proliferation; protein binding; positive regulation of peptidyl-tyrosine phosphorylation;
GATA6	8	blood coagulation; positive regulation of angiogenesis; cellular response to hypoxia; protein binding; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; in utero embryonic development;
APOA1	8	blood coagulation; extracellular region; secretory granule; extracellular space; platelet activation; protein binding; platelet degranulation; identical protein binding;
PIK3CG	8	blood coagulation; membrane; cytoplasm; platelet activation; protein binding; negative regulation of apoptotic process; angiogenesis; positive regulation of MAP kinase activity;
BNIP3	8	protein homodimerization activity; protein heterodimerization activity; cytoplasm; cellular response to hypoxia; protein binding; negative regulation of apoptotic process; response to hypoxia; identical protein binding;
AXIN1	8	protein homodimerization activity; cytoplasm; positive regulation of protein phosphorylation; activation of protein kinase activity; protein binding; in utero embryonic development; positive regulation of peptidyl-serine phosphorylation; identical protein binding;
HNF1B	8	protein homodimerization activity; branching morphogenesis of a tube; protein heterodimerization activity; protein binding; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; kidney development;
IL18	8	extracellular region; lung development; extracellular space; positive regulation of gene expression; positive regulation of vascular permeability; cytokine activity; angiogenesis; response to hypoxia;
ERBB2	8	positive regulation of epithelial cell proliferation; protein heterodimerization activity; positive regulation of protein phosphorylation; protein binding; positive regulation of MAP kinase activity; identical protein binding; positive regulation of cell adhesion; nervous system development;
SEMA4D	8	extracellular space; positive regulation of protein phosphorylation; protein binding; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-tyrosine phosphorylation; regulation of cell shape; positive regulation of cell migration;
ADAM17	8	cytoplasm; cell surface; positive regulation of protein phosphorylation; positive regulation of cell proliferation; protein binding; response to hypoxia; positive regulation of cellular component movement; positive regulation of cell migration;
FLCN	8	cytoplasm; positive regulation of protein phosphorylation; positive regulation of gene expression; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; in utero embryonic development; positive regulation of cell adhesion;
MED1	8	lactation; monocyte differentiation; positive regulation of gene expression; protein binding; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; angiogenesis;
TGFBR1	8	positive regulation of cell proliferation; protein binding; negative regulation of apoptotic process; angiogenesis; in utero embryonic development; artery morphogenesis; positive regulation of cellular component movement; kidney development;
SERPING1	7	platelet alpha granule lumen; blood coagulation; extracellular region; extracellular space; platelet activation; protein binding; platelet degranulation;
ALDOA	7	platelet alpha granule lumen; blood coagulation; extracellular region; platelet activation; platelet degranulation; identical protein binding; regulation of cell shape;
EREG	7	positive regulation of cell division; extracellular region; extracellular space; growth factor activity; positive regulation of cell proliferation; protein binding; angiogenesis;
APC	7	positive regulation of cell division; cytoplasm; protein binding; negative regulation of apoptotic process; kidney development; positive regulation of cell adhesion; positive regulation of cell migration;
BCAR1	7	blood coagulation; cytoplasm; vascular endothelial growth factor receptor signaling pathway; platelet activation; protein binding; positive regulation of endothelial cell migration; positive regulation of cell migration;
PDE2A	7	blood coagulation; protein homodimerization activity; cytoplasm; monocyte differentiation; positive regulation of vascular permeability; protein binding; negative regulation of transcription from RNA polymerase II promoter;
KDM1A	7	blood coagulation; regulation of transcription from RNA polymerase II promoter; protein binding; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; in utero embryonic development;
GDNF	7	protein homodimerization activity; extracellular region; growth factor activity; positive regulation of branching involved in ureteric bud morphogenesis; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; nervous system development;
CRYAB	7	protein homodimerization activity; cytoplasm; cell surface; protein binding; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to hypoxia;
ACHE	7	protein homodimerization activity; extracellular region; membrane; extracellular space; cell surface; protein binding; nervous system development;
FOXP1	7	protein homodimerization activity; lung development; protein heterodimerization activity; cytoplasm; positive regulation of transcription from RNA polymerase II promoter; in utero embryonic development; positive regulation of mesenchymal cell proliferation;
TSC2	7	protein homodimerization activity; membrane; protein heterodimerization activity; positive chemotaxis; cytoplasm; protein binding; response to hypoxia;
FOXF1	7	vasculogenesis; lung development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; in utero embryonic development; positive regulation of mesenchymal cell proliferation; positive regulation of cell migration;
HEY2	7	vasculogenesis; cardiac vascular smooth muscle cell development; cytoplasm; outflow tract morphogenesis; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
IHH	7	extracellular region; extracellular space; cell maturation; positive regulation of transcription from RNA polymerase II promoter; in utero embryonic development; positive regulation of mesenchymal cell proliferation; patterning of blood vessels;
CLCF1	7	extracellular region; protein heterodimerization activity; growth factor activity; positive regulation of cell proliferation; protein binding; negative regulation of apoptotic process; cytokine activity;
INHA	7	extracellular region; protein heterodimerization activity; growth factor activity; ovarian follicle development; protein binding; cytokine activity; nervous system development;
SNCA	7	extracellular region; cytoplasm; protein binding; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of peptidyl-serine phosphorylation; identical protein binding;
PAK1	7	branching morphogenesis of a tube; cytoplasm; protein binding; positive regulation of peptidyl-serine phosphorylation; cellular response to stress; response to hypoxia; identical protein binding;
EDNRA	7	membrane; positive regulation of protein phosphorylation; positive regulation of cell proliferation; negative regulation of apoptotic process; in utero embryonic development; response to hypoxia; patterning of blood vessels;
NR4A2	7	protein heterodimerization activity; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; cellular response to stress; response to hypoxia; dopaminergic neuron differentiation;
ETS1	7	positive regulation of angiogenesis; positive regulation of cell proliferation; protein binding; positive regulation of transcription from RNA polymerase II promoter; response to hypoxia; positive regulation of cellular component movement; positive regulation of cell migration;
CREBBP	7	cytoplasm; cellular response to hypoxia; protein binding; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter in response to hypoxia; cellular response to stress; response to hypoxia;
BTC	6	positive regulation of cell division; extracellular region; extracellular space; growth factor activity; positive regulation of cell proliferation; negative regulation of apoptotic process;
ARRB1	6	blood coagulation; cytoplasm; platelet activation; protein binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation;
MAPK1	6	blood coagulation; cytoplasm; platelet activation; positive regulation of cell proliferation; protein binding; positive regulation of cell migration;
CFL1	6	blood coagulation; cytoplasm; platelet activation; protein binding; negative regulation of apoptotic process; platelet degranulation;
JAM3	6	blood coagulation; protein homodimerization activity; protein heterodimerization activity; extracellular space; protein binding; angiogenesis;
PIK3R1	6	blood coagulation; platelet activation; protein binding; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell migration;
HABP4	6	blood coagulation; extracellular region; cytoplasm; platelet activation; protein binding; platelet degranulation;
ADRA2C	6	blood coagulation; protein homodimerization activity; protein heterodimerization activity; cytoplasm; platelet activation; protein binding;
ARRB2	6	blood coagulation; cytoplasm; platelet activation; protein binding; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of receptor internalization;
F7	6	blood coagulation; extracellular region; positive regulation of positive chemotaxis; extracellular space; negative regulation of apoptotic process; positive regulation of cell migration;
HSPA5	6	blood coagulation; cell surface; platelet activation; protein binding; negative regulation of apoptotic process; platelet degranulation;
GHR	6	protein homodimerization activity; extracellular region; extracellular space; cell surface; protein binding; positive regulation of peptidyl-tyrosine phosphorylation;
VIL1	6	protein homodimerization activity; cytoplasm; protein binding; identical protein binding; regulation of cell shape; positive regulation of cell migration;
FZD4	6	protein homodimerization activity; vasculogenesis; protein heterodimerization activity; cytoplasm; cell surface; protein binding;
PDCD10	6	protein homodimerization activity; positive regulation of cell proliferation; protein binding; negative regulation of apoptotic process; angiogenesis; positive regulation of MAP kinase activity;
CORO1A	6	protein homodimerization activity; positive chemotaxis; cytoplasm; protein binding; regulation of cell shape; positive regulation of cell migration;
TPD52L1	6	protein homodimerization activity; protein heterodimerization activity; cytoplasm; protein binding; positive regulation of MAP kinase activity; identical protein binding;
YAP1	6	vasculogenesis; cytoplasm; positive regulation of cell proliferation; protein binding; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
WNT6	6	extracellular region; branching morphogenesis of a tube; extracellular space; cell surface; positive regulation of gene expression; proteinaceous extracellular matrix;
CXCL12	6	extracellular region; extracellular space; growth factor activity; negative regulation of apoptotic process; induction of positive chemotaxis; patterning of blood vessels;
PKD1	6	branching morphogenesis of a tube; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; in utero embryonic development; kidney development;
CDH13	6	positive regulation of positive chemotaxis; extracellular space; cytoplasm; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell migration;
MAP2K5	6	positive regulation of epithelial cell proliferation; protein binding; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
ISL1	6	positive regulation of angiogenesis; cytoplasm; outflow tract morphogenesis; positive regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
DRD2	6	positive regulation of neuroblast proliferation; activation of protein kinase activity; protein binding; positive regulation of transcription from RNA polymerase II promoter; response to hypoxia; positive regulation of receptor internalization;
ADAM8	6	cytoplasm; cell surface; cellular response to hypoxia; protein binding; angiogenesis; positive regulation of cell adhesion;
RELA	6	cytoplasm; positive regulation of cell proliferation; protein binding; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; identical protein binding;
EGLN3	6	cytoplasm; cellular response to hypoxia; protein binding; regulation of transcription from RNA polymerase II promoter in response to hypoxia; cellular response to stress; response to hypoxia;
RBPJ	6	cytoplasm; outflow tract morphogenesis; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; angiogenesis;
ID2	6	cytoplasm; positive regulation of gene expression; cell maturation; mammary gland alveolus development; protein binding; negative regulation of transcription from RNA polymerase II promoter;
GSK3B	6	cytoplasm; protein binding; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein complex assembly;
SOX8	6	cytoplasm; cell maturation; positive regulation of branching involved in ureteric bud morphogenesis; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; in utero embryonic development;
PRKAA1	6	cellular response to hypoxia; positive regulation of gene expression; positive regulation of cell proliferation; protein binding; negative regulation of apoptotic process; response to hypoxia;
UBB	6	cellular response to hypoxia; protein binding; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; cellular response to stress;
UBC	6	cellular response to hypoxia; protein binding; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; cellular response to stress;
TSC1	5	positive regulation of focal adhesion assembly; membrane; cytoplasm; protein binding; kidney development;
MEN1	5	positive regulation of cell division; cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
FGF3	5	positive regulation of cell division; extracellular region; growth factor activity; positive regulation of cell proliferation; protein binding;
TH	5	eye photoreceptor cell development; heart morphogenesis; cytoplasm; protein binding; response to hypoxia;
ZFPM1	5	blood coagulation; primitive erythrocyte differentiation; cytoplasm; outflow tract morphogenesis; protein binding;
SYK	5	blood coagulation; platelet activation; protein binding; angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation;
SERPINC1	5	blood coagulation; extracellular region; heparin binding; extracellular space; protein binding;
STX4	5	blood coagulation; membrane; cell surface; platelet activation; protein binding;
ADORA2A	5	blood coagulation; membrane; protein heterodimerization activity; protein binding; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;
MAPK3	5	blood coagulation; positive regulation of protein phosphorylation; platelet activation; protein binding; positive regulation of transcription from RNA polymerase II promoter;
MYB	5	blood coagulation; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; in utero embryonic development;
NTRK2	5	protein homodimerization activity; vasculogenesis; cell surface; positive regulation of gene expression; positive regulation of cell proliferation;
FOXP2	5	protein homodimerization activity; protein heterodimerization activity; growth; cytoplasm; positive regulation of mesenchymal cell proliferation;
SQSTM1	5	protein homodimerization activity; positive regulation of protein phosphorylation; protein binding; positive regulation of transcription from RNA polymerase II promoter; identical protein binding;
PRLR	5	protein homodimerization activity; extracellular region; cell surface; lactation; negative regulation of apoptotic process;
BARD1	5	protein homodimerization activity; protein heterodimerization activity; cytoplasm; protein binding; negative regulation of apoptotic process;
PLA2G1B	5	extracellular region; secretory granule; extracellular space; cell surface binding; positive regulation of transcription from RNA polymerase II promoter;
LPL	5	extracellular region; heparin binding; extracellular space; cell surface; protein binding;
CTSG	5	extracellular region; secretory granule; heparin binding; extracellular space; cell surface;
BDNF	5	extracellular region; cytoplasm; growth factor activity; response to hypoxia; nervous system development;
TTR	5	extracellular region; protein heterodimerization activity; extracellular space; cytoplasm; protein binding;
SEMA3E	5	extracellular region; membrane; extracellular space; regulation of cell shape; patterning of blood vessels;
CTF1	5	extracellular region; extracellular space; positive regulation of cell proliferation; cytokine activity; nervous system development;
FGF19	5	extracellular region; growth factor activity; positive regulation of cell proliferation; protein binding; nervous system development;
OGN	5	extracellular region; extracellular space; growth factor activity; protein binding; proteinaceous extracellular matrix;
NGF	5	extracellular region; extracellular space; positive regulation of protein autophosphorylation; growth factor activity; positive regulation of gene expression;
SREBF1	5	lung development; regulation of transcription from RNA polymerase II promoter; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
IKZF1	5	mesoderm development; protein heterodimerization activity; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
CCND1	5	membrane; positive regulation of protein phosphorylation; lactation; mammary gland alveolus development; protein binding;
CDC42EP2	5	membrane; cytoplasm; protein binding; positive regulation of protein complex assembly; regulation of cell shape;
CNTF	5	growth; extracellular space; cytoplasm; growth factor activity; positive regulation of cell proliferation;
MKL2	5	heart morphogenesis; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; in utero embryonic development;
AAMP	5	heparin binding; cytoplasm; cell surface; angiogenesis; positive regulation of endothelial cell migration;
ILK	5	cytoplasm; positive regulation of cell proliferation; protein binding; positive regulation of MAP kinase activity; positive regulation of cell migration;
DNAJA3	5	cytoplasm; protein binding; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;
DAB2	5	positive regulation of protein phosphorylation; protein binding; negative regulation of apoptotic process; in utero embryonic development; positive regulation of cell migration;
TCEB1	5	cellular response to hypoxia; regulation of transcription from RNA polymerase II promoter; protein binding; regulation of transcription from RNA polymerase II promoter in response to hypoxia; cellular response to stress;

Genes shared at least 2 KEGG pathways with VEGFA (count: 14)

Gene Symbol	Pathway Count	Pathway List
MAPK3	6	VEGF signaling pathway; Bladder cancer; Focal adhesion; Renal cell carcinoma; mTOR signaling pathway; Pancreatic cancer;
MAPK1	6	VEGF signaling pathway; Bladder cancer; Focal adhesion; Renal cell carcinoma; mTOR signaling pathway; Pancreatic cancer;
VEGFB	6	Bladder cancer; Focal adhesion; Renal cell carcinoma; mTOR signaling pathway; Cytokine-cytokine receptor interaction; Pancreatic cancer;
PIK3CG	5	VEGF signaling pathway; Focal adhesion; Renal cell carcinoma; mTOR signaling pathway; Pancreatic cancer;
PIK3R1	5	VEGF signaling pathway; Focal adhesion; Renal cell carcinoma; mTOR signaling pathway; Pancreatic cancer;
BAD	3	VEGF signaling pathway; Focal adhesion; Pancreatic cancer;
CCND1	3	Bladder cancer; Focal adhesion; Pancreatic cancer;
ERBB2	3	Bladder cancer; Focal adhesion; Pancreatic cancer;
PDPK1	2	Focal adhesion; mTOR signaling pathway;
CRKL	2	Focal adhesion; Renal cell carcinoma;
MAPK9	2	Focal adhesion; Pancreatic cancer;
PAK1	2	Focal adhesion; Renal cell carcinoma;
PAK7	2	Focal adhesion; Renal cell carcinoma;
TGFBR1	2	Cytokine-cytokine receptor interaction; Pancreatic cancer;

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Region: chr6:43737921..43754224 View in gBrowse