ADHDgene Database

Gene Report

Basic Info

Approved Symbol	WNT6
Approved Name	wingless-type MMTV integration site family, member 6
Location	2q35
Position	chr2:219724544-219738955, 1
External Links	HGNC: 12785 Entrez Gene: 7475 Ensembl: ENSG00000115596 UCSC: uc002vjc.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001664	G-protein coupled receptor binding	molecular function	IBA	9
GO:0005576	extracellular region	cellular component	NAS	267
GO:0072079	nephron tubule formation	biological process	IEA	1
GO:0009952	anterior/posterior pattern specification	biological process	IBA	26
GO:0005578	proteinaceous extracellular matrix	cellular component	IEA	51
GO:0048754	branching morphogenesis of a tube	biological process	IBA	7
GO:0001658	branching involved in ureteric bud morphogenesis	biological process	IEA	8
GO:0042475	odontogenesis of dentin-containing tooth	biological process	IMP	8
GO:0070172	positive regulation of tooth mineralization	biological process	IMP	1
GO:0005886	plasma membrane	cellular component	IBA	839
GO:0045893	positive regulation of transcription, DNA-dependent	biological process	IEA	89
GO:0071300	cellular response to retinoic acid	biological process	ISS	8
GO:0009986	cell surface	cellular component	IEA	75
GO:0005615	extracellular space	cellular component	IBA	133
GO:0060684	epithelial-mesenchymal cell signaling	biological process	IEA	1
GO:0072080	nephron tubule development	biological process	IBA	1
GO:0007267	cell-cell signaling	biological process	NAS	41
GO:0010628	positive regulation of gene expression	biological process	IMP	29
GO:0060070	canonical Wnt receptor signaling pathway	biological process	IBA	16
GO:0009798	axis specification	biological process	IBA	4
GO:0061303	cornea development in camera-type eye	biological process	ISS[16258938]	1
GO:0030182	neuron differentiation	biological process	ISS	10

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene
hsa05217	Basal cell carcinoma	9
hsa04916	Melanogenesis	18
hsa04310	Wnt signaling pathway	25
hsa04340	Hedgehog signaling pathway	8

Genes shared at least 5 GO terms with WNT6 (count: 6)

Gene Symbol	Pathway Count	Pathway List
WNT11	11	G-protein coupled receptor binding; anterior/posterior pattern specification; proteinaceous extracellular matrix; plasma membrane; positive regulation of transcription, DNA-dependent; cellular response to retinoic acid; extracellular space; positive regulation of gene expression; canonical Wnt receptor signaling pathway; axis specification; neuron differentiation;
WNT10A	8	G-protein coupled receptor binding; anterior/posterior pattern specification; proteinaceous extracellular matrix; plasma membrane; extracellular space; positive regulation of gene expression; canonical Wnt receptor signaling pathway; axis specification;
FGF10	7	extracellular region; branching morphogenesis of a tube; odontogenesis of dentin-containing tooth; plasma membrane; positive regulation of transcription, DNA-dependent; cell surface; extracellular space;
VEGFA	6	extracellular region; proteinaceous extracellular matrix; branching morphogenesis of a tube; cell surface; extracellular space; positive regulation of gene expression;
FZD4	6	plasma membrane; positive regulation of transcription, DNA-dependent; cellular response to retinoic acid; cell surface; canonical Wnt receptor signaling pathway; neuron differentiation;
CTGF	5	extracellular region; proteinaceous extracellular matrix; plasma membrane; extracellular space; positive regulation of gene expression;

Genes shared at least 2 KEGG pathways with WNT6 (count: 13)

Gene Symbol	Pathway Count	Pathway List
WNT11	4	Basal cell carcinoma; Melanogenesis; Wnt signaling pathway; Hedgehog signaling pathway;
GSK3B	4	Basal cell carcinoma; Melanogenesis; Wnt signaling pathway; Hedgehog signaling pathway;
WNT10A	4	Basal cell carcinoma; Melanogenesis; Wnt signaling pathway; Hedgehog signaling pathway;
FZD4	3	Basal cell carcinoma; Melanogenesis; Wnt signaling pathway;
STK36	2	Basal cell carcinoma; Hedgehog signaling pathway;
PTCH1	2	Basal cell carcinoma; Hedgehog signaling pathway;
APC	2	Basal cell carcinoma; Wnt signaling pathway;
AXIN1	2	Basal cell carcinoma; Wnt signaling pathway;
CAMK2D	2	Melanogenesis; Wnt signaling pathway;
PLCB3	2	Melanogenesis; Wnt signaling pathway;
PLCB2	2	Melanogenesis; Wnt signaling pathway;
CREBBP	2	Melanogenesis; Wnt signaling pathway;
CSNK1E	2	Wnt signaling pathway; Hedgehog signaling pathway;

View in gBrowse

Region: chr2:219724544..219738955 View in gBrowse