ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0045893
Name	positive regulation of transcription, DNA-dependent
Type	biological process
No. of Genes in ADHDgene	89
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 89)

Literature-origin genes (count: 10)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
MAP2K3	mitogen-activated protein kinase kinase 3	17q11.2	1(0/1/0)	IDA[11980910]
SUPT3H	suppressor of Ty 3 homolog (S. cerevisiae)	6p21.1-p12.3	1(0/0/1)	NAS[9787080]
HAS3	hyaluronan synthase 3	16q22.1	1(0/0/1)	IDA[16900089]
FGF10	fibroblast growth factor 10	5p13-p12	1(0/1/0)	IDA[17500053]
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	2p25	1(0/1/0)	ISS
NPAS3	neuronal PAS domain protein 3	14q13.1	1(1/0/0)	ISS
ETV5	ets variant 5	3q28	1(1/0/0)	IEA
ZNF423	zinc finger protein 423	16q12	1(0/0/1)	IDA[10660046]
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	6p12	1(1/0/0)	IDA[11505339]; IMP[16373396]
CREB5	cAMP responsive element binding protein 5	7p15	1(0/0/1)	IDA[8378084]

Genes from other sources (count: 79)

Approved Symbol	Approved Name	Source	Evidence[PMID]
KAT5	K(lysine) acetyltransferase 5	Mapped by significant region	IDA[14966270]; NAS[15572661]
RSF1	remodeling and spacing factor 1	Mapped by significant region	IDA[11788598]
FOXE1	forkhead box E1 (thyroid transcription factor 2)	Mapped by significant region	IDA[9697705]
MMS19	MMS19 nucleotide excision repair homolog (S. cerevisiae)	Mapped by PBA pathway	IMP[11279242]
DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	Mapped by significant region	IMP[12805222]
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	Mapped by CNV	IDA[19343227]
MYB	v-myb avian myeloblastosis viral oncogene homolog	Mapped by significant region	IMP; NAS[2189102]
HINFP	histone H4 transcription factor	Mapped by significant region	IDA[17163457]
CIITA	class II, major histocompatibility complex, transactivator	Mapped by significant region	IDA[19041327]
ANKRD49	ankyrin repeat domain 49	Mapped by significant region	IDA[11162141]
CREBBP	CREB binding protein	Mapped by significant region	IDA[11742995]; ISS
RREB1	ras responsive element binding protein 1	Mapped by CNV	TAS[9305772]
MAPK1	mitogen-activated protein kinase 1	Mapped by LD-proxy	IEA
CDK5RAP2	CDK5 regulatory subunit associated protein 2	Mapped by significant region	IDA[19282672]
MED17	mediator complex subunit 17	Mapped by significant region; Mapped by PBA pathway	IDA[10198638]
SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	Mapped by PBA pathway	IDA[14701856]
HMGA1	high mobility group AT-hook 1	Mapped by PBA pathway	IMP[10428834]
NSD1	nuclear receptor binding SET domain protein 1	Mapped by PBA pathway	IDA[11509567]
ZNF287	zinc finger protein 287	Mapped by significant region	IEA
TBX1	T-box 1	Mapped by CNV	IDA[17273972]; ISS
MAPK9	mitogen-activated protein kinase 9	Mapped by CNV	IEA
FZD4	frizzled class receptor 4	Mapped by significant region	IDA[17955262]
CRLF3	cytokine receptor-like factor 3	Mapped by CNV	IDA[19427400]
HNF1B	HNF1 homeobox B	Mapped by CNV	IDA
LGR4	leucine-rich repeat containing G protein-coupled receptor 4	Mapped by LD-proxy	IEA
FEV	FEV (ETS oncogene family)	Mapped by significant region	IEA
NCOA6	nuclear receptor coactivator 6	Mapped by PBA pathway	TAS[12519782]
THRAP3	thyroid hormone receptor associated protein 3	Mapped by PBA pathway	IDA[10198638]
IL6	interleukin 6 (interferon, beta 2)	Mapped by significant region	IDA[7749983]
EBF1	early B-cell factor 1	Mapped by significant region	IEA
TGFB1I1	transforming growth factor beta 1 induced transcript 1	Mapped by PBA pathway	IDA[10075738]; NAS[15572661]
ROR2	receptor tyrosine kinase-like orphan receptor 2	Mapped by significant region	IEA
NRIP1	nuclear receptor interacting protein 1	Mapped by PBA pathway	NAS[15572661]
ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	Mapped by significant region	IDA[11909962]
RFX6	regulatory factor X, 6	Mapped by significant region	IDA
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene	Mapped by LD-proxy	IDA[12833137]
MED13	mediator complex subunit 13	Mapped by PBA pathway	IDA[10198638]
MYRF	myelin regulatory factor	Mapped by LD-proxy; Mapped by significant region	ISS
ZBTB16	zinc finger and BTB domain containing 16	Mapped by significant region	IDA
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta	Mapped by PBA pathway	IDA[15790729]
TFAP4	transcription factor AP-4 (activating enhancer binding protein 4)	Mapped by significant region	IMP[12663744]
SOX8	SRY (sex determining region Y)-box 8	Mapped by significant region	ISS
MED1	mediator complex subunit 1	Mapped by LD-proxy; Mapped by PBA pathway	IDA[10198638]
RRN3	RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)	Mapped by CNV; Mapped by significant region	IEA
RNF20	ring finger protein 20, E3 ubiquitin protein ligase	Mapped by significant region	IMP[16713563]
KMT2A	lysine (K)-specific methyltransferase 2A	Mapped by significant region	IMP[15960975]
WNT6	wingless-type MMTV integration site family, member 6	Mapped by significant region	IEA
LHX1	LIM homeobox 1	Mapped by CNV	ISS
TGFBR1	transforming growth factor, beta receptor 1	Mapped by significant region	IDA[9389648]
PICALM	phosphatidylinositol binding clathrin assembly protein	Mapped by significant region	IDA[11425879]
ILK	integrin-linked kinase	Mapped by CNV	IMP
RAN	RAN, member RAS oncogene family	Mapped by PBA pathway	NAS[15572661]
LRP5	low density lipoprotein receptor-related protein 5	Mapped by CNV; Mapped by significant region	IDA[17955262]
IRF8	interferon regulatory factor 8	Mapped by significant region	IEA
LHX2	LIM homeobox 2	Mapped by significant region	ISS
MED16	mediator complex subunit 16	Mapped by PBA pathway	IDA[10198638]
USP22	ubiquitin specific peptidase 22	Mapped by significant region	IMP[18206973]
TP53BP1	tumor protein p53 binding protein 1	Mapped by Literature SNP	NAS[9748285]
GLIS2	GLIS family zinc finger 2	Mapped by significant region	ISS
MED24	mediator complex subunit 24	Mapped by PBA pathway	IDA[10198638]
PHF5A	PHD finger protein 5A	Mapped by PBA pathway	ISS
FOXF1	forkhead box F1	Mapped by significant region	IDA[9769171]
WNT11	wingless-type MMTV integration site family, member 11	Mapped by significant region	IMP[19847889]
RELA	v-rel avian reticuloendotheliosis viral oncogene homolog A	Mapped by significant region	IDA[18073330]
KAT8	K(lysine) acetyltransferase 8	Mapped by CNV	IDA[11742995]; IMP[15960975]
MED30	mediator complex subunit 30	Mapped by PBA pathway	IDA[10198638]
MED4	mediator complex subunit 4	Mapped by PBA pathway	IDA[10198638]
KLF4	Kruppel-like factor 4 (gut)	Mapped by significant region	ISS; NAS[9422764]
IRF7	interferon regulatory factor 7	Mapped by LD-proxy	IMP[12374802]
MED12	mediator complex subunit 12	Mapped by PBA pathway	IDA[10198638]
PSRC1	proline/serine-rich coiled-coil 1	Mapped by CNV	ISS[12427559]
NPAT	nuclear protein, ataxia-telangiectasia locus	Mapped by CNV; Mapped by significant region	IDA[18850719]
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	Mapped by significant region	IDA[9169153]
AXIN1	axin 1	Mapped by significant region	IMP[16601693]
TASP1	taspase, threonine aspartase, 1	Mapped by CNV	IMP[14636557]
MED14	mediator complex subunit 14	Mapped by PBA pathway	IDA[10198638]
ATMIN	ATM interactor	Mapped by significant region	IDA
NUP62	nucleoporin 62kDa	Mapped by PBA pathway	IDA[15625236]; ISS
HOXA11	homeobox A11	Mapped by significant region	ISS