ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	STK36
Symbol Alias	KIAA1278, FU
Approved Name	serine/threonine kinase 36
Previous Name	"serine/threonine kinase 36 (fused homolog, Drosophila)"
Name Alias	"fused homolog (Drosophila)"
Location	2q35
Position	chr2:219536749-219567439, 1
External Links	HGNC: 17209 Entrez Gene: 27148 Ensembl: ENSG00000163482 UCSC: uc002viu.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045880	positive regulation of smoothened signaling pathway	biological process	ISS	3
GO:0004674	protein serine/threonine kinase activity	molecular function	NAS; TAS[10806483]	65
GO:0000287	magnesium ion binding	molecular function	IC[10806483]	30
GO:0007228	positive regulation of hh target transcription factor activity	biological process	ISS	1
GO:0042384	cilium assembly	biological process	ISS	16
GO:0005737	cytoplasm	cellular component	IDA[10806483]	781
GO:0003351	epithelial cilium movement	biological process	IEA	1
GO:0008134	transcription factor binding	molecular function	IDA[10806483]	44
GO:0005634	nucleus	cellular component	IDA[10806483]	877
GO:0007420	brain development	biological process	IEA	36
GO:0006468	protein phosphorylation	biological process	NAS; TAS[10806483]	58
GO:0009791	post-embryonic development	biological process	ISS	17
GO:0005515	protein binding	molecular function	IPI[10806483]	1015
GO:0005524	ATP binding	molecular function	NAS; TAS[10806483]	265
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	biological process	IDA[10806483]	17

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05217	Basal cell carcinoma	9
hsa04340	Hedgehog signaling pathway	8

Genes shared at least 5 GO terms with STK36 (count: 32)

Gene Symbol	Pathway Count	Pathway List
STK11	7	protein serine/threonine kinase activity; magnesium ion binding; cytoplasm; nucleus; protein phosphorylation; protein binding; ATP binding;
MAPK1	7	protein serine/threonine kinase activity; cytoplasm; transcription factor binding; nucleus; protein binding; ATP binding; regulation of sequence-specific DNA binding transcription factor activity;
RPS6KA4	7	protein serine/threonine kinase activity; magnesium ion binding; cytoplasm; nucleus; protein phosphorylation; protein binding; ATP binding;
SIK2	7	protein serine/threonine kinase activity; magnesium ion binding; cytoplasm; nucleus; protein phosphorylation; protein binding; ATP binding;
NEK6	7	protein serine/threonine kinase activity; magnesium ion binding; cytoplasm; nucleus; protein phosphorylation; protein binding; ATP binding;
CDC42BPG	6	protein serine/threonine kinase activity; magnesium ion binding; cytoplasm; protein phosphorylation; protein binding; ATP binding;
GSK3B	6	protein serine/threonine kinase activity; cytoplasm; nucleus; protein phosphorylation; protein binding; ATP binding;
TNNI3K	6	protein serine/threonine kinase activity; cytoplasm; nucleus; protein phosphorylation; protein binding; ATP binding;
TSSK2	6	protein serine/threonine kinase activity; magnesium ion binding; cytoplasm; protein phosphorylation; protein binding; ATP binding;
SIK3	6	protein serine/threonine kinase activity; magnesium ion binding; cytoplasm; protein phosphorylation; protein binding; ATP binding;
MARK2	6	protein serine/threonine kinase activity; magnesium ion binding; nucleus; protein phosphorylation; protein binding; ATP binding;
ROCK2	5	protein serine/threonine kinase activity; nucleus; protein phosphorylation; protein binding; ATP binding;
PDPK1	5	protein serine/threonine kinase activity; cytoplasm; protein phosphorylation; protein binding; ATP binding;
TSSK4	5	protein serine/threonine kinase activity; magnesium ion binding; protein phosphorylation; protein binding; ATP binding;
SMG1	5	protein serine/threonine kinase activity; cytoplasm; nucleus; protein binding; ATP binding;
CSNK1E	5	protein serine/threonine kinase activity; nucleus; protein phosphorylation; protein binding; ATP binding;
LATS2	5	protein serine/threonine kinase activity; nucleus; protein phosphorylation; protein binding; ATP binding;
TGFBR1	5	protein serine/threonine kinase activity; protein phosphorylation; post-embryonic development; protein binding; ATP binding;
PAK1	5	protein serine/threonine kinase activity; cytoplasm; protein phosphorylation; protein binding; ATP binding;
MAP3K11	5	protein serine/threonine kinase activity; cytoplasm; protein phosphorylation; protein binding; ATP binding;
PLK1	5	protein serine/threonine kinase activity; nucleus; protein phosphorylation; protein binding; ATP binding;
ILK	5	protein serine/threonine kinase activity; cytoplasm; protein phosphorylation; protein binding; ATP binding;
PRKD1	5	protein serine/threonine kinase activity; cytoplasm; nucleus; protein binding; ATP binding;
LATS1	5	protein serine/threonine kinase activity; magnesium ion binding; protein phosphorylation; protein binding; ATP binding;
AURKC	5	protein serine/threonine kinase activity; cytoplasm; nucleus; protein phosphorylation; ATP binding;
SGK1	5	protein serine/threonine kinase activity; nucleus; protein phosphorylation; ATP binding; regulation of sequence-specific DNA binding transcription factor activity;
UBE2I	5	cytoplasm; transcription factor binding; nucleus; protein binding; ATP binding;
FRK	5	cytoplasm; nucleus; protein phosphorylation; protein binding; ATP binding;
IGHMBP2	5	cytoplasm; transcription factor binding; nucleus; protein binding; ATP binding;
DNAJA3	5	cytoplasm; transcription factor binding; nucleus; protein binding; ATP binding;
FOXG1	5	transcription factor binding; nucleus; brain development; protein binding; regulation of sequence-specific DNA binding transcription factor activity;
MAPK3	5	nucleus; protein phosphorylation; protein binding; ATP binding; regulation of sequence-specific DNA binding transcription factor activity;

Genes shared at least 2 KEGG pathways with STK36 (count: 5)

Gene Symbol	Pathway Count	Pathway List
WNT11	2	Basal cell carcinoma; Hedgehog signaling pathway;
GSK3B	2	Basal cell carcinoma; Hedgehog signaling pathway;
PTCH1	2	Basal cell carcinoma; Hedgehog signaling pathway;
WNT6	2	Basal cell carcinoma; Hedgehog signaling pathway;
WNT10A	2	Basal cell carcinoma; Hedgehog signaling pathway;

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Region: chr2:219536749..219567439 View in gBrowse