ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	STK36
Symbol Alias	KIAA1278, FU
Approved Name	serine/threonine kinase 36
Previous Name	serine/threonine kinase 36 (fused homolog, Drosophila)
Name Alias	fused homolog (Drosophila)
Location	2q35
Position	chr2:219536749-219567440, +
External Links	HGNC: 17209 Entrez Gene: 27148 Ensembl: ENSG00000163482 UCSC: uc002viu.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	Biological Process	IDA[10806483]	16
GO:0045880	positive regulation of smoothened signaling pathway	Biological Process		3
GO:0006468	protein phosphorylation	Biological Process	TAS[10806483]	53
GO:0007228	positive regulation of hh target transcription factor activity	Biological Process		1
GO:0005634	nucleus	Cellular Component	IDA[10806483]	770
GO:0005737	cytoplasm	Cellular Component	IDA[10806483]	690
GO:0009791	post-embryonic development	Biological Process		16
GO:0042384	cilium assembly	Biological Process		15
GO:0007420	brain development	Biological Process		33
GO:0008134	transcription factor binding	Molecular Function	IDA[10806483]	38
GO:0000287	magnesium ion binding	Molecular Function	IC[10806483]	28
GO:0005515	protein binding	Molecular Function	IPI[10806483]	910
GO:0005524	ATP binding	Molecular Function	TAS[10806483]	228
GO:0003351	epithelial cilium movement	Biological Process		1
GO:0004674	protein serine/threonine kinase activity	Molecular Function	TAS[10806483]	61

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04340	Hedgehog signaling pathway	8	The Hedgehog (Hh) family of secreted signaling proteins play...... The Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and organs. Hh signaling is also involved in control of stem cell proliferation in adult tissues and aberrant activation of the Hh pathway has been linked to multiple types of human cancer. Members of the Hh family bind to patched (ptc), thus releasing smoothened (smo) to transduce a signal. Transcriptional activation occurs through the GLI family of proteins resulting in activation of target genes. More...
hsa05217	Basal cell carcinoma	8	Cancer of the skin is the most common cancer in Caucasians a...... Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare familial syndrome basal cell nevus syndrome (BCNS, or Gorlin syndrome) that predisposes to development of BCC. In addition, there is strong epidemiological and genetic evidence that demonstrates UV exposure as a risk factor of prime importance. The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog signaling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC. More...
hsa05200	Pathways in cancer	52

Genes shared at least 5 GO terms with STK36 (count: 28)

Gene Symbol	Pathway Count	Pathway List
MAPK1	7	regulation of sequence-specific DNA binding transcription factor activity; nucleus; cytoplasm; transcription factor binding; protein binding; ATP binding; protein serine/threonine kinase activity;
NEK6	7	protein phosphorylation; nucleus; cytoplasm; magnesium ion binding; protein binding; ATP binding; protein serine/threonine kinase activity;
RPS6KA4	7	protein phosphorylation; nucleus; cytoplasm; magnesium ion binding; protein binding; ATP binding; protein serine/threonine kinase activity;
SIK2	7	protein phosphorylation; nucleus; cytoplasm; magnesium ion binding; protein binding; ATP binding; protein serine/threonine kinase activity;
CDC42BPG	6	protein phosphorylation; cytoplasm; magnesium ion binding; protein binding; ATP binding; protein serine/threonine kinase activity;
GSK3B	6	protein phosphorylation; nucleus; cytoplasm; protein binding; ATP binding; protein serine/threonine kinase activity;
MARK2	6	protein phosphorylation; nucleus; magnesium ion binding; protein binding; ATP binding; protein serine/threonine kinase activity;
PRKCB	6	protein phosphorylation; nucleus; cytoplasm; protein binding; ATP binding; protein serine/threonine kinase activity;
SIK3	6	protein phosphorylation; cytoplasm; magnesium ion binding; protein binding; ATP binding; protein serine/threonine kinase activity;
TSSK2	6	protein phosphorylation; cytoplasm; magnesium ion binding; protein binding; ATP binding; protein serine/threonine kinase activity;
FOXG1	5	regulation of sequence-specific DNA binding transcription factor activity; nucleus; brain development; transcription factor binding; protein binding;
MAPK3	5	regulation of sequence-specific DNA binding transcription factor activity; protein phosphorylation; nucleus; protein binding; ATP binding;
SGK1	5	regulation of sequence-specific DNA binding transcription factor activity; protein phosphorylation; nucleus; ATP binding; protein serine/threonine kinase activity;
AURKC	5	protein phosphorylation; nucleus; cytoplasm; ATP binding; protein serine/threonine kinase activity;
CSNK1E	5	protein phosphorylation; nucleus; protein binding; ATP binding; protein serine/threonine kinase activity;
FRK	5	protein phosphorylation; nucleus; cytoplasm; protein binding; ATP binding;
ILK	5	protein phosphorylation; cytoplasm; protein binding; ATP binding; protein serine/threonine kinase activity;
LATS1	5	protein phosphorylation; magnesium ion binding; protein binding; ATP binding; protein serine/threonine kinase activity;
LATS2	5	protein phosphorylation; nucleus; protein binding; ATP binding; protein serine/threonine kinase activity;
MAP3K11	5	protein phosphorylation; cytoplasm; protein binding; ATP binding; protein serine/threonine kinase activity;
PAK1	5	protein phosphorylation; cytoplasm; protein binding; ATP binding; protein serine/threonine kinase activity;
PLK1	5	protein phosphorylation; nucleus; protein binding; ATP binding; protein serine/threonine kinase activity;
ROCK2	5	protein phosphorylation; nucleus; protein binding; ATP binding; protein serine/threonine kinase activity;
TGFBR1	5	protein phosphorylation; post-embryonic development; protein binding; ATP binding; protein serine/threonine kinase activity;
TSSK4	5	protein phosphorylation; magnesium ion binding; protein binding; ATP binding; protein serine/threonine kinase activity;
IGHMBP2	5	nucleus; cytoplasm; transcription factor binding; protein binding; ATP binding;
PRKD1	5	nucleus; cytoplasm; protein binding; ATP binding; protein serine/threonine kinase activity;
SMG1	5	nucleus; cytoplasm; protein binding; ATP binding; protein serine/threonine kinase activity;

Genes shared at least 2 KEGG pathways with STK36 (count: 7)

Gene Symbol	Pathway Count	Pathway List
GSK3B	3	Hedgehog signaling pathway; Basal cell carcinoma; Pathways in cancer;
PTCH1	3	Hedgehog signaling pathway; Basal cell carcinoma; Pathways in cancer;
WNT10A	3	Hedgehog signaling pathway; Basal cell carcinoma; Pathways in cancer;
WNT11	3	Hedgehog signaling pathway; Basal cell carcinoma; Pathways in cancer;
WNT6	3	Hedgehog signaling pathway; Basal cell carcinoma; Pathways in cancer;
APC	2	Basal cell carcinoma; Pathways in cancer;
FZD4	2	Basal cell carcinoma; Pathways in cancer;

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Region: chr2:219536749..219567440 View in gBrowse