ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SGK1
Previous Symbol	SGK
Approved Name	serum/glucocorticoid regulated kinase 1
Previous Name	serum/glucocorticoid regulated kinase
Location	6q23
Position	chr6:134490384-134639250, -
External Links	HGNC: 10810 Entrez Gene: 6446 Ensembl: ENSG00000118515 UCSC: uc003qeo.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
6q22-23	chr6:114600000-139000000	1 (1/0/0)

Gene related GO terms (count: 26)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005886	plasma membrane	Cellular Component		772
GO:0006468	protein phosphorylation	Biological Process	TAS[9114008]	53
GO:0005739	mitochondrion	Cellular Component		183
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0005524	ATP binding	Molecular Function		228
GO:0005634	nucleus	Cellular Component		770
GO:0004674	protein serine/threonine kinase activity	Molecular Function		61
GO:0005246	calcium channel regulator activity	Molecular Function		10
GO:0001558	regulation of cell growth	Biological Process		11
GO:0060453	regulation of gastric acid secretion	Biological Process		1
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	Biological Process		16
GO:0050790	regulation of catalytic activity	Biological Process		2
GO:0042981	regulation of apoptotic process	Biological Process		32
GO:0042127	regulation of cell proliferation	Biological Process		20
GO:0032411	positive regulation of transporter activity	Biological Process		2
GO:0030334	regulation of cell migration	Biological Process		10
GO:0017081	chloride channel regulator activity	Molecular Function		2
GO:0017080	sodium channel regulator activity	Molecular Function		7
GO:0015459	potassium channel regulator activity	Molecular Function		7
GO:0008217	regulation of blood pressure	Biological Process	TAS[16460280]	8
GO:0007616	long-term memory	Biological Process		4
GO:0006974	response to DNA damage stimulus	Biological Process		37
GO:0006950	response to stress	Biological Process	TAS[9114008]	30
GO:0006915	apoptotic process	Biological Process		111
GO:0006814	sodium ion transport	Biological Process	TAS[10884438]	9
GO:0070294	renal sodium ion absorption	Biological Process	TAS[16460280]	2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04960	Aldosterone-regulated sodium reabsorption	13	Sodium transport across the tight epithelia of Na+ reabsorbi...... Sodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-term blood pressure. Aldosterone plays a major role in sodium and potassium metabolism by binding to epithelial mineralocorticoid receptors (MR) in the renal collecting duct cells localized in the distal nephron, promoting sodium resorption and potassium excretion. Aldosterone enters a target cell and binds MR, which translocates into the nucleus and regulates gene transcription. Activation of MR leads to increased expression of Sgk-1, which phosphorylates Nedd4-2, an ubiquitin-ligase which targets ENAC to proteosomal degradation. Phosphorylated Nedd4-2 dissociates from ENAC, increasing its apical membrane abundance. Activation of MR also leads to increased expression of Na+/K+-ATPase, thus causing a net increase in sodium uptake from the renal filtrate. The specificity of MR for aldosterone is provided by 11beta-HSD2 by the rapid conversion of cortisol to cortisone in renal cortical collecting duct cells. Recently, besides genomic effects mediated by activated MR, rapid aldosterone actions that are independent of translation and transcription have been documented. More...

Genes shared at least 5 GO terms with SGK1 (count: 15)

Gene Symbol	Pathway Count	Pathway List
MAPK1	8	mitochondrion; ATP binding; nucleus; protein serine/threonine kinase activity; regulation of sequence-specific DNA binding transcription factor activity; response to DNA damage stimulus; response to stress; apoptotic process;
PRKCB	7	plasma membrane; protein phosphorylation; ATP binding; nucleus; protein serine/threonine kinase activity; calcium channel regulator activity; apoptotic process;
MAPK3	7	protein phosphorylation; mitochondrion; ATP binding; nucleus; regulation of sequence-specific DNA binding transcription factor activity; response to DNA damage stimulus; apoptotic process;
TAOK2	7	ATP binding; nucleus; protein serine/threonine kinase activity; regulation of cell growth; response to DNA damage stimulus; response to stress; apoptotic process;
TGFBR1	6	plasma membrane; protein phosphorylation; ATP binding; protein serine/threonine kinase activity; regulation of apoptotic process; apoptotic process;
ERN2	6	protein phosphorylation; endoplasmic reticulum membrane; ATP binding; protein serine/threonine kinase activity; response to stress; apoptotic process;
GSK3B	5	plasma membrane; protein phosphorylation; ATP binding; nucleus; protein serine/threonine kinase activity;
MARK2	5	plasma membrane; protein phosphorylation; ATP binding; nucleus; protein serine/threonine kinase activity;
PAK1	5	plasma membrane; protein phosphorylation; ATP binding; protein serine/threonine kinase activity; apoptotic process;
PRKD1	5	plasma membrane; ATP binding; nucleus; protein serine/threonine kinase activity; apoptotic process;
ROCK2	5	plasma membrane; protein phosphorylation; ATP binding; nucleus; protein serine/threonine kinase activity;
NEK6	5	protein phosphorylation; ATP binding; nucleus; protein serine/threonine kinase activity; apoptotic process;
STK36	5	protein phosphorylation; ATP binding; nucleus; protein serine/threonine kinase activity; regulation of sequence-specific DNA binding transcription factor activity;
PAK7	5	mitochondrion; ATP binding; nucleus; protein serine/threonine kinase activity; apoptotic process;
CHEK1	5	ATP binding; nucleus; protein serine/threonine kinase activity; regulation of cell proliferation; response to DNA damage stimulus;

Genes shared at least 2 KEGG pathways with SGK1 (count: 0)

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Region: chr6:134490384..134639250 View in gBrowse