ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MAP3K11
Previous Symbol	MLK3, PTK1
Symbol Alias	SPRK, MEKK11
Approved Name	mitogen-activated protein kinase kinase kinase 11
Location	11q13.1-q13.3
Position	chr11:65365226-65382853, -
External Links	HGNC: 6850 Entrez Gene: 4296 Ensembl: ENSG00000173327 UCSC: uc001oew.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 26)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048365	Rac GTPase binding	Molecular Function		5
GO:0046777	protein autophosphorylation	Biological Process	IDA[8195146]	23
GO:0046330	positive regulation of JNK cascade	Biological Process	IMP[17584736]	12
GO:0043525	positive regulation of neuron apoptotic process	Biological Process		9
GO:0043507	positive regulation of JUN kinase activity	Biological Process	IMP[17584736]	6
GO:0042803	protein homodimerization activity	Molecular Function	IPI[9829970]	113
GO:0042802	identical protein binding	Molecular Function	IPI[9829970]	70
GO:0031435	mitogen-activated protein kinase kinase kinase binding	Molecular Function	IPI[17584736]	7
GO:0031434	mitogen-activated protein kinase kinase binding	Molecular Function		3
GO:0008283	cell proliferation	Biological Process	IMP[15258589]	60
GO:0008219	cell death	Biological Process		33
GO:0007257	activation of JUN kinase activity	Biological Process	IMP[15258589]	8
GO:0007254	JNK cascade	Biological Process	TAS[10799501]	11
GO:0007017	microtubule-based process	Biological Process	IMP[12529434]	4
GO:0006468	protein phosphorylation	Biological Process	IDA[11053428]	53
GO:0005874	microtubule	Cellular Component	IDA[12529434]	52
GO:0005737	cytoplasm	Cellular Component		690
GO:0005813	centrosome	Cellular Component	IDA[12529434]	71
GO:0005515	protein binding	Molecular Function		910
GO:0005524	ATP binding	Molecular Function		228
GO:0004706	JUN kinase kinase kinase activity	Molecular Function		1
GO:0004713	protein tyrosine kinase activity	Molecular Function		10
GO:0004672	protein kinase activity	Molecular Function	TAS[8183572]	27
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA[8195146]	61
GO:0000080	G1 phase of mitotic cell cycle	Biological Process	IMP[15258589]	6
GO:0000187	activation of MAPK activity	Biological Process	IMP[15258589]	21

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04010	MAPK signaling pathway	69	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...

Genes shared at least 5 GO terms with MAP3K11 (count: 45)

Gene Symbol	Pathway Count	Pathway List
PAK1	9	protein autophosphorylation; positive regulation of JUN kinase activity; identical protein binding; protein phosphorylation; cytoplasm; protein binding; ATP binding; protein kinase activity; protein serine/threonine kinase activity;
MAP4K2	8	positive regulation of JNK cascade; mitogen-activated protein kinase kinase kinase binding; activation of JUN kinase activity; JNK cascade; protein phosphorylation; protein binding; ATP binding; protein serine/threonine kinase activity;
ERBB2	7	protein autophosphorylation; identical protein binding; cell proliferation; protein phosphorylation; protein binding; ATP binding; protein tyrosine kinase activity;
NEK6	7	protein autophosphorylation; protein phosphorylation; microtubule; cytoplasm; protein binding; ATP binding; protein serine/threonine kinase activity;
PRKD1	7	protein autophosphorylation; identical protein binding; cell proliferation; cytoplasm; protein binding; ATP binding; protein serine/threonine kinase activity;
SYK	7	protein autophosphorylation; cell proliferation; activation of JUN kinase activity; protein phosphorylation; protein binding; ATP binding; protein kinase activity;
TSSK2	7	protein autophosphorylation; identical protein binding; protein phosphorylation; cytoplasm; protein binding; ATP binding; protein serine/threonine kinase activity;
MAP3K5	7	protein homodimerization activity; identical protein binding; activation of JUN kinase activity; JNK cascade; protein binding; ATP binding; protein kinase activity;
PLK1	7	cell proliferation; protein phosphorylation; centrosome; protein binding; ATP binding; protein kinase activity; protein serine/threonine kinase activity;
FES	6	protein autophosphorylation; cell proliferation; protein phosphorylation; cytoplasm; ATP binding; protein tyrosine kinase activity;
SIK2	6	protein autophosphorylation; protein phosphorylation; cytoplasm; protein binding; ATP binding; protein serine/threonine kinase activity;
SMG1	6	protein autophosphorylation; cytoplasm; protein binding; ATP binding; protein kinase activity; protein serine/threonine kinase activity;
MAPK1	6	mitogen-activated protein kinase kinase kinase binding; cytoplasm; protein binding; ATP binding; protein serine/threonine kinase activity; activation of MAPK activity;
ILK	6	cell proliferation; protein phosphorylation; cytoplasm; protein binding; ATP binding; protein serine/threonine kinase activity;
CDC42BPG	6	protein phosphorylation; cytoplasm; centrosome; protein binding; ATP binding; protein serine/threonine kinase activity;
GSK3B	6	protein phosphorylation; cytoplasm; centrosome; protein binding; ATP binding; protein serine/threonine kinase activity;
AATK	5	protein autophosphorylation; protein binding; ATP binding; protein tyrosine kinase activity; protein serine/threonine kinase activity;
ATM	5	protein autophosphorylation; positive regulation of neuron apoptotic process; protein binding; ATP binding; protein serine/threonine kinase activity;
FLT4	5	protein autophosphorylation; positive regulation of JNK cascade; cytoplasm; protein binding; ATP binding;
MARK2	5	protein autophosphorylation; protein phosphorylation; protein binding; ATP binding; protein serine/threonine kinase activity;
MUSK	5	protein autophosphorylation; positive regulation of neuron apoptotic process; protein binding; ATP binding; protein tyrosine kinase activity;
WNK2	5	protein autophosphorylation; protein phosphorylation; cytoplasm; ATP binding; protein serine/threonine kinase activity;
TAOK2	5	positive regulation of JNK cascade; mitogen-activated protein kinase kinase binding; cytoplasm; ATP binding; protein serine/threonine kinase activity;
TPD52L1	5	positive regulation of JNK cascade; protein homodimerization activity; identical protein binding; cytoplasm; protein binding;
TFAP2A	5	positive regulation of neuron apoptotic process; protein homodimerization activity; cytoplasm; centrosome; protein binding;
DAB2IP	5	positive regulation of JUN kinase activity; protein homodimerization activity; mitogen-activated protein kinase kinase kinase binding; activation of JUN kinase activity; cytoplasm;
BNIP3	5	protein homodimerization activity; identical protein binding; cell death; cytoplasm; protein binding;
CEP57	5	protein homodimerization activity; microtubule; cytoplasm; centrosome; protein binding;
PAFAH1B1	5	protein homodimerization activity; microtubule-based process; cytoplasm; centrosome; protein binding;
HOOK3	5	identical protein binding; microtubule; cytoplasm; centrosome; protein binding;
RIPK3	5	identical protein binding; protein binding; ATP binding; protein kinase activity; protein serine/threonine kinase activity;
TTK	5	identical protein binding; protein binding; ATP binding; protein tyrosine kinase activity; protein serine/threonine kinase activity;
MAPRE1	5	cell proliferation; microtubule; cytoplasm; centrosome; protein binding;
AURKC	5	protein phosphorylation; cytoplasm; ATP binding; protein kinase activity; protein serine/threonine kinase activity;
CSNK1E	5	protein phosphorylation; protein binding; ATP binding; protein kinase activity; protein serine/threonine kinase activity;
MARK4	5	protein phosphorylation; centrosome; protein binding; ATP binding; protein serine/threonine kinase activity;
PRKAA1	5	protein phosphorylation; protein binding; ATP binding; protein kinase activity; activation of MAPK activity;
PRKCB	5	protein phosphorylation; cytoplasm; protein binding; ATP binding; protein serine/threonine kinase activity;
ROCK2	5	protein phosphorylation; centrosome; protein binding; ATP binding; protein serine/threonine kinase activity;
RPS6KA4	5	protein phosphorylation; cytoplasm; protein binding; ATP binding; protein serine/threonine kinase activity;
SIK3	5	protein phosphorylation; cytoplasm; protein binding; ATP binding; protein serine/threonine kinase activity;
STK36	5	protein phosphorylation; cytoplasm; protein binding; ATP binding; protein serine/threonine kinase activity;
TGFBR1	5	protein phosphorylation; protein binding; ATP binding; protein kinase activity; protein serine/threonine kinase activity;
PIK3CG	5	cytoplasm; protein binding; ATP binding; protein kinase activity; protein serine/threonine kinase activity;
MAP2K3	5	protein binding; ATP binding; protein tyrosine kinase activity; protein serine/threonine kinase activity; activation of MAPK activity;

Genes shared at least 2 KEGG pathways with MAP3K11 (count: 0)

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Region: chr11:65365226..65382853 View in gBrowse