ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MAP3K11
Previous Symbol	MLK3, PTK1
Symbol Alias	SPRK, MEKK11
Approved Name	mitogen-activated protein kinase kinase kinase 11
Location	11q13.1-q13.3
Position	chr11:65365226-65382853, -1
External Links	HGNC: 6850 Entrez Gene: 4296 Ensembl: ENSG00000173327 UCSC: uc001oew.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 26)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004672	protein kinase activity	molecular function	TAS[8183572]	31
GO:0000080	G1 phase of mitotic cell cycle	biological process	IMP[15258589]	5
GO:0008283	cell proliferation	biological process	IMP[15258589]	66
GO:0004713	protein tyrosine kinase activity	molecular function	IEA	11
GO:0005524	ATP binding	molecular function	IEA	265
GO:0005813	centrosome	cellular component	IDA[12529434]	78
GO:0042803	protein homodimerization activity	molecular function	IPI[9829970]	128
GO:0007257	activation of JUN kinase activity	biological process	IMP[15258589]	10
GO:0046330	positive regulation of JNK cascade	biological process	IMP[17584736]	15
GO:0042802	identical protein binding	molecular function	IPI[9829970]	77
GO:0031435	mitogen-activated protein kinase kinase kinase binding	molecular function	IPI[17584736]	8
GO:0005515	protein binding	molecular function	IPI	1015
GO:0048365	Rac GTPase binding	molecular function	IEA	5
GO:0007017	microtubule-based process	biological process	IMP[12529434]	4
GO:0006468	protein phosphorylation	biological process	IDA[11053428]	58
GO:0043525	positive regulation of neuron apoptotic process	biological process	IEA	10
GO:0004674	protein serine/threonine kinase activity	molecular function	IDA[8195146]	65
GO:0031434	mitogen-activated protein kinase kinase binding	molecular function	IEA	4
GO:0046777	protein autophosphorylation	biological process	IDA[8195146]	26
GO:0007254	JNK cascade	biological process	TAS[10799501]	12
GO:0005874	microtubule	cellular component	IDA[12529434]	62
GO:0000187	activation of MAPK activity	biological process	IMP[15258589]	22
GO:0004706	JUN kinase kinase kinase activity	molecular function	ISS	1
GO:0008219	cell death	biological process	IEA	33
GO:0005737	cytoplasm	cellular component	IEA	781
GO:0043507	positive regulation of JUN kinase activity	biological process	IMP[17584736]	8

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MAP3K11 (count: 48)

Gene Symbol	Pathway Count	Pathway List
PAK1	9	protein kinase activity; ATP binding; identical protein binding; protein binding; protein phosphorylation; protein serine/threonine kinase activity; protein autophosphorylation; cytoplasm; positive regulation of JUN kinase activity;
MAP4K2	8	ATP binding; activation of JUN kinase activity; positive regulation of JNK cascade; mitogen-activated protein kinase kinase kinase binding; protein binding; protein phosphorylation; protein serine/threonine kinase activity; JNK cascade;
MAP3K5	7	protein kinase activity; ATP binding; protein homodimerization activity; activation of JUN kinase activity; identical protein binding; protein binding; JNK cascade;
PLK1	7	protein kinase activity; cell proliferation; ATP binding; centrosome; protein binding; protein phosphorylation; protein serine/threonine kinase activity;
SYK	7	protein kinase activity; cell proliferation; ATP binding; activation of JUN kinase activity; protein binding; protein phosphorylation; protein autophosphorylation;
ERBB2	7	cell proliferation; protein tyrosine kinase activity; ATP binding; identical protein binding; protein binding; protein phosphorylation; protein autophosphorylation;
PRKD1	7	cell proliferation; ATP binding; identical protein binding; protein binding; protein serine/threonine kinase activity; protein autophosphorylation; cytoplasm;
NEK6	7	ATP binding; protein binding; protein phosphorylation; protein serine/threonine kinase activity; protein autophosphorylation; microtubule; cytoplasm;
STK11	7	ATP binding; identical protein binding; protein binding; protein phosphorylation; protein serine/threonine kinase activity; protein autophosphorylation; cytoplasm;
TSSK2	7	ATP binding; identical protein binding; protein binding; protein phosphorylation; protein serine/threonine kinase activity; protein autophosphorylation; cytoplasm;
AXIN1	7	protein homodimerization activity; activation of JUN kinase activity; positive regulation of JNK cascade; identical protein binding; protein binding; cell death; cytoplasm;
MAP2K5	6	protein kinase activity; protein tyrosine kinase activity; ATP binding; protein binding; protein serine/threonine kinase activity; activation of MAPK activity;
TNNI3K	6	protein kinase activity; ATP binding; protein binding; protein phosphorylation; protein serine/threonine kinase activity; cytoplasm;
SMG1	6	protein kinase activity; ATP binding; protein binding; protein serine/threonine kinase activity; protein autophosphorylation; cytoplasm;
ILK	6	cell proliferation; ATP binding; protein binding; protein phosphorylation; protein serine/threonine kinase activity; cytoplasm;
FES	6	cell proliferation; protein tyrosine kinase activity; ATP binding; protein phosphorylation; protein autophosphorylation; cytoplasm;
CDC42BPG	6	ATP binding; centrosome; protein binding; protein phosphorylation; protein serine/threonine kinase activity; cytoplasm;
GSK3B	6	ATP binding; centrosome; protein binding; protein phosphorylation; protein serine/threonine kinase activity; cytoplasm;
SIK2	6	ATP binding; protein binding; protein phosphorylation; protein serine/threonine kinase activity; protein autophosphorylation; cytoplasm;
PDPK1	6	ATP binding; protein binding; protein phosphorylation; protein serine/threonine kinase activity; protein autophosphorylation; cytoplasm;
MAPK1	6	ATP binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein serine/threonine kinase activity; activation of MAPK activity; cytoplasm;
AURKC	5	protein kinase activity; ATP binding; protein phosphorylation; protein serine/threonine kinase activity; cytoplasm;
TGFBR1	5	protein kinase activity; ATP binding; protein binding; protein phosphorylation; protein serine/threonine kinase activity;
CSNK1E	5	protein kinase activity; ATP binding; protein binding; protein phosphorylation; protein serine/threonine kinase activity;
PIK3CG	5	protein kinase activity; ATP binding; protein binding; protein serine/threonine kinase activity; cytoplasm;
PRKAA1	5	protein kinase activity; ATP binding; protein binding; protein phosphorylation; activation of MAPK activity;
RIPK3	5	protein kinase activity; ATP binding; identical protein binding; protein binding; protein serine/threonine kinase activity;
MAPRE1	5	cell proliferation; centrosome; protein binding; microtubule; cytoplasm;
TTK	5	protein tyrosine kinase activity; ATP binding; identical protein binding; protein binding; protein serine/threonine kinase activity;
MUSK	5	protein tyrosine kinase activity; ATP binding; protein binding; positive regulation of neuron apoptotic process; protein autophosphorylation;
AATK	5	protein tyrosine kinase activity; ATP binding; protein binding; protein serine/threonine kinase activity; protein autophosphorylation;
MAP2K3	5	protein tyrosine kinase activity; ATP binding; protein binding; protein serine/threonine kinase activity; activation of MAPK activity;
ROCK2	5	ATP binding; centrosome; protein binding; protein phosphorylation; protein serine/threonine kinase activity;
SIK3	5	ATP binding; protein binding; protein phosphorylation; protein serine/threonine kinase activity; cytoplasm;
FLT4	5	ATP binding; positive regulation of JNK cascade; protein binding; protein autophosphorylation; cytoplasm;
ATM	5	ATP binding; protein binding; positive regulation of neuron apoptotic process; protein serine/threonine kinase activity; protein autophosphorylation;
TAOK2	5	ATP binding; positive regulation of JNK cascade; protein serine/threonine kinase activity; mitogen-activated protein kinase kinase binding; cytoplasm;
RPS6KA4	5	ATP binding; protein binding; protein phosphorylation; protein serine/threonine kinase activity; cytoplasm;
MARK4	5	ATP binding; centrosome; protein binding; protein phosphorylation; protein serine/threonine kinase activity;
STK36	5	ATP binding; protein binding; protein phosphorylation; protein serine/threonine kinase activity; cytoplasm;
MARK2	5	ATP binding; protein binding; protein phosphorylation; protein serine/threonine kinase activity; protein autophosphorylation;
WNK2	5	ATP binding; protein phosphorylation; protein serine/threonine kinase activity; protein autophosphorylation; cytoplasm;
CEP57	5	centrosome; protein homodimerization activity; protein binding; microtubule; cytoplasm;
HOOK3	5	centrosome; identical protein binding; protein binding; microtubule; cytoplasm;
PAFAH1B1	5	centrosome; protein homodimerization activity; protein binding; microtubule-based process; cytoplasm;
BNIP3	5	protein homodimerization activity; identical protein binding; protein binding; cell death; cytoplasm;
DAB2IP	5	protein homodimerization activity; activation of JUN kinase activity; mitogen-activated protein kinase kinase kinase binding; cytoplasm; positive regulation of JUN kinase activity;
TPD52L1	5	protein homodimerization activity; positive regulation of JNK cascade; identical protein binding; protein binding; cytoplasm;

Genes shared at least 2 KEGG pathways with MAP3K11 (count: 0)

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Region: chr11:65365226..65382853 View in gBrowse