ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FRK
Previous Symbol	PTK5
Symbol Alias	RAK, GTK
Approved Name	fyn-related kinase
Previous Name	PTK5 protein tyrosine kinase 5
Location	6q21-q22.3
Position	chr6:116262693-116381921, -
External Links	HGNC: 3955 Entrez Gene: 2444 Ensembl: ENSG00000111816 UCSC: uc003pwi.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
6q22-23	chr6:114600000-139000000	1 (1/0/0)

Gene related GO terms (count: 10)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004715	non-membrane spanning protein tyrosine kinase activity	Molecular Function		6
GO:0005515	protein binding	Molecular Function	IPI[19345329]	910
GO:0005524	ATP binding	Molecular Function		228
GO:0005622	intracellular	Cellular Component	TAS[7510261]	67
GO:0005634	nucleus	Cellular Component		770
GO:0005737	cytoplasm	Cellular Component		690
GO:0005886	plasma membrane	Cellular Component		772
GO:0006468	protein phosphorylation	Biological Process	TAS[7696183]	53
GO:0008285	negative regulation of cell proliferation	Biological Process	TAS[7664264]	59
GO:0030154	cell differentiation	Biological Process		51

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with FRK (count: 24)

Gene Symbol	Pathway Count	Pathway List
GSK3B	6	protein binding; ATP binding; nucleus; cytoplasm; plasma membrane; protein phosphorylation;
PRKCB	6	protein binding; ATP binding; nucleus; cytoplasm; plasma membrane; protein phosphorylation;
SYK	5	non-membrane spanning protein tyrosine kinase activity; protein binding; ATP binding; plasma membrane; protein phosphorylation;
APC	5	protein binding; nucleus; cytoplasm; plasma membrane; negative regulation of cell proliferation;
ARVCF	5	protein binding; intracellular; nucleus; cytoplasm; plasma membrane;
CHD1L	5	protein binding; ATP binding; nucleus; cytoplasm; plasma membrane;
EHD3	5	protein binding; ATP binding; nucleus; cytoplasm; plasma membrane;
ERBB2	5	protein binding; ATP binding; nucleus; plasma membrane; protein phosphorylation;
FLT4	5	protein binding; ATP binding; nucleus; cytoplasm; plasma membrane;
HSPA8	5	protein binding; ATP binding; intracellular; nucleus; plasma membrane;
ILK	5	protein binding; ATP binding; cytoplasm; plasma membrane; protein phosphorylation;
MAGI2	5	protein binding; nucleus; cytoplasm; plasma membrane; negative regulation of cell proliferation;
MARK2	5	protein binding; ATP binding; nucleus; plasma membrane; protein phosphorylation;
NEK6	5	protein binding; ATP binding; nucleus; cytoplasm; protein phosphorylation;
NF2	5	protein binding; nucleus; cytoplasm; plasma membrane; negative regulation of cell proliferation;
PAK1	5	protein binding; ATP binding; cytoplasm; plasma membrane; protein phosphorylation;
PRKAA1	5	protein binding; ATP binding; intracellular; nucleus; protein phosphorylation;
PRKD1	5	protein binding; ATP binding; nucleus; cytoplasm; plasma membrane;
PRKG1	5	protein binding; ATP binding; cytoplasm; plasma membrane; protein phosphorylation;
ROCK2	5	protein binding; ATP binding; nucleus; plasma membrane; protein phosphorylation;
RPS6KA4	5	protein binding; ATP binding; nucleus; cytoplasm; protein phosphorylation;
SIK2	5	protein binding; ATP binding; nucleus; cytoplasm; protein phosphorylation;
STK36	5	protein binding; ATP binding; nucleus; cytoplasm; protein phosphorylation;
WNK2	5	ATP binding; cytoplasm; plasma membrane; protein phosphorylation; negative regulation of cell proliferation;

Genes shared at least 2 KEGG pathways with FRK (count: 0)

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Region: chr6:116262693..116381921 View in gBrowse