ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PRKAA1
Symbol Alias	AMPKa1
Approved Name	protein kinase, AMP-activated, alpha 1 catalytic subunit
Name Alias	"AMPK, alpha, 1"
Location	5p13.1
Position	chr5:40759481-40798476, -1
External Links	HGNC: 9376 Entrez Gene: 5562 Ensembl: ENSG00000132356 UCSC: uc003jmb.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5p	chr5:0-48400000	1 (1/0/0)
5p13	chr5:28900000-42500000	3 (1/1/1)

Gene related GO terms (count: 60)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 60)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0055089	fatty acid homeostasis	biological process	ISS	3
GO:0043066	negative regulation of apoptotic process	biological process	ISS	85
GO:0006914	autophagy	biological process	IEA	16
GO:0006950	response to stress	biological process	ISS	31
GO:0046320	regulation of fatty acid oxidation	biological process	TAS	6
GO:0071456	cellular response to hypoxia	biological process	IEA	14
GO:0008286	insulin receptor signaling pathway	biological process	TAS	37
GO:0006006	glucose metabolic process	biological process	IEA	20
GO:0007165	signal transduction	biological process	TAS[8557660]	189
GO:0047322	[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity	molecular function	IEA	1
GO:0009631	cold acclimation	biological process	IEA	1
GO:0006695	cholesterol biosynthetic process	biological process	IEA	8
GO:2001274	negative regulation of glucose import in response to insulin stimulus	biological process	IEA	1
GO:0014823	response to activity	biological process	IEA	7
GO:0000187	activation of MAPK activity	biological process	NAS[11546797]	22
GO:0005515	protein binding	molecular function	IPI	1015
GO:0050405	[acetyl-CoA carboxylase] kinase activity	molecular function	IEA	1
GO:0051291	protein heterooligomerization	biological process	IEA	13
GO:0016324	apical plasma membrane	cellular component	IEA	52
GO:0050321	tau-protein kinase activity	molecular function	IEA	5
GO:0019900	kinase binding	molecular function	IEA	8
GO:2000505	regulation of energy homeostasis	biological process	ISS	1
GO:0071361	cellular response to ethanol	biological process	IEA	3
GO:0006468	protein phosphorylation	biological process	IDA[17028174]	58
GO:0019395	fatty acid oxidation	biological process	IEA	3
GO:0032007	negative regulation of TOR signaling cascade	biological process	ISS	5
GO:0035174	histone serine kinase activity	molecular function	ISS	2
GO:0042149	cellular response to glucose starvation	biological process	ISS	4
GO:0006633	fatty acid biosynthetic process	biological process	IEA	16
GO:0007050	cell cycle arrest	biological process	TAS	28
GO:0006351	transcription, DNA-dependent	biological process	IEA	281
GO:0005634	nucleus	cellular component	ISS	877
GO:0016055	Wnt receptor signaling pathway	biological process	IEA	25
GO:0048511	rhythmic process	biological process	IEA	2
GO:0008284	positive regulation of cell proliferation	biological process	IEA	75
GO:0004691	cAMP-dependent protein kinase activity	molecular function	NAS[8557660]	1
GO:0031588	AMP-activated protein kinase complex	cellular component	ISS	4
GO:0046872	metal ion binding	molecular function	IEA	200
GO:0010508	positive regulation of autophagy	biological process	ISS	3
GO:0004672	protein kinase activity	molecular function	IDA[17028174]	31
GO:0042593	glucose homeostasis	biological process	ISS	21
GO:0046318	negative regulation of glucosylceramide biosynthetic process	biological process	NAS[11165240]	1
GO:0031000	response to caffeine	biological process	IEA	6
GO:0050995	negative regulation of lipid catabolic process	biological process	ISS	5
GO:0004679	AMP-activated protein kinase activity	molecular function	IDA[18439900]	3
GO:0005622	intracellular	cellular component	IC[8557660]	83
GO:0042752	regulation of circadian rhythm	biological process	ISS	1
GO:0070301	cellular response to hydrogen peroxide	biological process	IEA	10
GO:0031669	cellular response to nutrient levels	biological process	ISS	2
GO:0008022	protein C-terminus binding	molecular function	IEA	42
GO:0045542	positive regulation of cholesterol biosynthetic process	biological process	NAS[8557660]	2
GO:0008610	lipid biosynthetic process	biological process	ISS	3
GO:0010628	positive regulation of gene expression	biological process	IDA[17028174]	29
GO:0005524	ATP binding	molecular function	IEA	265
GO:0006355	regulation of transcription, DNA-dependent	biological process	IEA	182
GO:0060627	regulation of vesicle-mediated transport	biological process	IEA	2
GO:0005829	cytosol	cellular component	TAS	485
GO:0003682	chromatin binding	molecular function	ISS	50
GO:0001666	response to hypoxia	biological process	NAS[8557660]	41
GO:0045821	positive regulation of glycolysis	biological process	ISS	2

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene
hsa04140	Regulation of autophagy	5
hsa04910	Insulin signaling pathway	29
hsa04150	mTOR signaling pathway	15
hsa04920	Adipocytokine signaling pathway	9

Genes shared at least 5 GO terms with PRKAA1 (count: 110)

Gene Symbol	Pathway Count	Pathway List
STK11	11	autophagy; regulation of fatty acid oxidation; insulin receptor signaling pathway; protein binding; protein heterooligomerization; protein phosphorylation; cell cycle arrest; nucleus; glucose homeostasis; ATP binding; cytosol;
INS	10	fatty acid homeostasis; negative regulation of apoptotic process; insulin receptor signaling pathway; glucose metabolic process; protein binding; positive regulation of cell proliferation; glucose homeostasis; negative regulation of lipid catabolic process; regulation of transcription, DNA-dependent; positive regulation of glycolysis;
TGFBR1	10	negative regulation of apoptotic process; signal transduction; protein binding; protein phosphorylation; cell cycle arrest; positive regulation of cell proliferation; metal ion binding; protein kinase activity; ATP binding; regulation of transcription, DNA-dependent;
MAPK1	10	response to stress; insulin receptor signaling pathway; signal transduction; activation of MAPK activity; protein binding; transcription, DNA-dependent; nucleus; positive regulation of cell proliferation; ATP binding; cytosol;
MAP2K5	9	negative regulation of apoptotic process; signal transduction; activation of MAPK activity; protein binding; nucleus; metal ion binding; protein kinase activity; ATP binding; cytosol;
PRKAB2	9	regulation of fatty acid oxidation; insulin receptor signaling pathway; signal transduction; protein binding; fatty acid biosynthetic process; cell cycle arrest; AMP-activated protein kinase complex; AMP-activated protein kinase activity; cytosol;
PRKAG3	8	regulation of fatty acid oxidation; insulin receptor signaling pathway; fatty acid biosynthetic process; cell cycle arrest; AMP-activated protein kinase complex; AMP-activated protein kinase activity; ATP binding; cytosol;
TSC2	8	insulin receptor signaling pathway; protein binding; protein heterooligomerization; negative regulation of TOR signaling cascade; cell cycle arrest; nucleus; cytosol; response to hypoxia;
ERBB2	8	signal transduction; protein binding; apical plasma membrane; protein phosphorylation; transcription, DNA-dependent; nucleus; protein C-terminus binding; ATP binding;
CRYAB	7	negative regulation of apoptotic process; glucose metabolic process; protein binding; nucleus; metal ion binding; cytosol; response to hypoxia;
PLK1	7	negative regulation of apoptotic process; protein binding; protein phosphorylation; nucleus; protein kinase activity; ATP binding; cytosol;
TFAP2B	7	negative regulation of apoptotic process; glucose metabolic process; protein binding; nucleus; positive regulation of cell proliferation; glucose homeostasis; regulation of transcription, DNA-dependent;
ATM	7	negative regulation of apoptotic process; signal transduction; protein binding; histone serine kinase activity; cell cycle arrest; ATP binding; response to hypoxia;
MAPK7	7	negative regulation of apoptotic process; signal transduction; protein binding; nucleus; cellular response to hydrogen peroxide; ATP binding; cytosol;
GSK3B	7	negative regulation of apoptotic process; protein binding; tau-protein kinase activity; protein phosphorylation; nucleus; ATP binding; cytosol;
SMG1	7	response to stress; protein binding; nucleus; metal ion binding; protein kinase activity; ATP binding; cytosol;
PRKAG2	7	regulation of fatty acid oxidation; insulin receptor signaling pathway; fatty acid biosynthetic process; cell cycle arrest; AMP-activated protein kinase complex; ATP binding; cytosol;
CREBBP	7	cellular response to hypoxia; signal transduction; protein binding; nucleus; regulation of transcription, DNA-dependent; chromatin binding; response to hypoxia;
MAPK3	7	insulin receptor signaling pathway; activation of MAPK activity; protein binding; protein phosphorylation; nucleus; ATP binding; cytosol;
PDPK1	7	insulin receptor signaling pathway; protein binding; protein phosphorylation; transcription, DNA-dependent; ATP binding; regulation of transcription, DNA-dependent; cytosol;
SREBF1	7	insulin receptor signaling pathway; protein binding; transcription, DNA-dependent; nucleus; positive regulation of cholesterol biosynthetic process; lipid biosynthetic process; chromatin binding;
CSNK1E	7	signal transduction; protein binding; protein phosphorylation; nucleus; protein kinase activity; ATP binding; cytosol;
APBB1	7	signal transduction; protein binding; cell cycle arrest; transcription, DNA-dependent; nucleus; regulation of transcription, DNA-dependent; chromatin binding;
TLE1	7	signal transduction; protein binding; nucleus; Wnt receptor signaling pathway; positive regulation of gene expression; cytosol; chromatin binding;
TNNI3K	7	protein binding; protein phosphorylation; nucleus; metal ion binding; protein kinase activity; protein C-terminus binding; ATP binding;
ILK	7	protein binding; protein heterooligomerization; protein phosphorylation; cell cycle arrest; positive regulation of cell proliferation; ATP binding; cytosol;
BNIP3	6	negative regulation of apoptotic process; cellular response to hypoxia; protein binding; nucleus; cellular response to hydrogen peroxide; response to hypoxia;
VEGFA	6	negative regulation of apoptotic process; cellular response to hypoxia; protein binding; positive regulation of cell proliferation; positive regulation of gene expression; response to hypoxia;
XRCC5	6	negative regulation of apoptotic process; protein binding; transcription, DNA-dependent; nucleus; protein C-terminus binding; ATP binding;
BIRC2	6	negative regulation of apoptotic process; protein binding; transcription, DNA-dependent; nucleus; regulation of transcription, DNA-dependent; cytosol;
DAB2	6	negative regulation of apoptotic process; protein binding; apical plasma membrane; nucleus; Wnt receptor signaling pathway; protein C-terminus binding;
YAP1	6	negative regulation of apoptotic process; protein binding; nucleus; positive regulation of cell proliferation; cytosol; chromatin binding;
RELA	6	negative regulation of apoptotic process; protein binding; nucleus; positive regulation of cell proliferation; cytosol; chromatin binding;
DNAJA3	6	negative regulation of apoptotic process; protein binding; nucleus; metal ion binding; ATP binding; cytosol;
FGF4	6	negative regulation of apoptotic process; insulin receptor signaling pathway; signal transduction; nucleus; positive regulation of cell proliferation; cytosol;
TSC1	6	insulin receptor signaling pathway; protein binding; protein heterooligomerization; negative regulation of TOR signaling cascade; cell cycle arrest; cytosol;
PRKD1	6	signal transduction; protein binding; nucleus; metal ion binding; ATP binding; cytosol;
EEF1D	6	signal transduction; protein binding; transcription, DNA-dependent; nucleus; regulation of transcription, DNA-dependent; cytosol;
RIPK3	6	signal transduction; protein binding; protein heterooligomerization; protein kinase activity; ATP binding; cytosol;
HSPA8	6	protein binding; transcription, DNA-dependent; nucleus; intracellular; ATP binding; cytosol;
ETS1	6	protein binding; transcription, DNA-dependent; nucleus; positive regulation of cell proliferation; cellular response to hydrogen peroxide; response to hypoxia;
HINFP	6	protein binding; transcription, DNA-dependent; nucleus; positive regulation of gene expression; regulation of transcription, DNA-dependent; chromatin binding;
CTNND1	6	protein binding; transcription, DNA-dependent; nucleus; Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; cytosol;
LATS2	6	protein binding; protein phosphorylation; nucleus; metal ion binding; ATP binding; cytosol;
PAK1	6	protein binding; protein phosphorylation; protein kinase activity; ATP binding; cytosol; response to hypoxia;
MARK2	6	protein binding; tau-protein kinase activity; protein phosphorylation; nucleus; Wnt receptor signaling pathway; ATP binding;
MEN1	6	protein binding; cell cycle arrest; transcription, DNA-dependent; nucleus; cytosol; chromatin binding;
ROCK2	6	protein binding; protein phosphorylation; nucleus; metal ion binding; ATP binding; cytosol;
CNOT6	6	protein binding; transcription, DNA-dependent; nucleus; metal ion binding; regulation of transcription, DNA-dependent; cytosol;
GATA6	5	negative regulation of apoptotic process; cellular response to hypoxia; protein binding; nucleus; chromatin binding;
BARD1	5	negative regulation of apoptotic process; protein binding; kinase binding; cell cycle arrest; nucleus;
PIK3R1	5	negative regulation of apoptotic process; insulin receptor signaling pathway; protein binding; protein phosphorylation; cytosol;
APC	5	negative regulation of apoptotic process; protein binding; cell cycle arrest; nucleus; cytosol;
PIK3CG	5	negative regulation of apoptotic process; protein binding; protein kinase activity; ATP binding; cytosol;
FLT4	5	negative regulation of apoptotic process; protein binding; nucleus; positive regulation of cell proliferation; ATP binding;
MED1	5	negative regulation of apoptotic process; protein binding; nucleus; positive regulation of gene expression; chromatin binding;
GSTP1	5	negative regulation of apoptotic process; protein binding; nucleus; intracellular; cytosol;
TNFAIP3	5	negative regulation of apoptotic process; protein binding; kinase binding; nucleus; cytosol;
CBL	5	negative regulation of apoptotic process; protein binding; nucleus; regulation of transcription, DNA-dependent; cytosol;
HSPA5	5	negative regulation of apoptotic process; protein binding; cellular response to glucose starvation; nucleus; ATP binding;
KDM1A	5	negative regulation of apoptotic process; protein binding; transcription, DNA-dependent; nucleus; chromatin binding;
SQSTM1	5	autophagy; response to stress; protein binding; protein heterooligomerization; cytosol;
MAPK9	5	response to stress; protein binding; positive regulation of gene expression; ATP binding; cytosol;
ATF6	5	response to stress; signal transduction; protein binding; transcription, DNA-dependent; nucleus;
ERN2	5	response to stress; protein phosphorylation; cell cycle arrest; transcription, DNA-dependent; ATP binding;
FLCN	5	response to stress; protein binding; negative regulation of TOR signaling cascade; nucleus; positive regulation of gene expression;
BAD	5	cellular response to hypoxia; protein binding; positive regulation of autophagy; glucose homeostasis; cytosol;
UBB	5	cellular response to hypoxia; activation of MAPK activity; protein binding; transcription, DNA-dependent; cytosol;
UBC	5	cellular response to hypoxia; activation of MAPK activity; protein binding; transcription, DNA-dependent; cytosol;
EGLN3	5	cellular response to hypoxia; protein binding; nucleus; cytosol; response to hypoxia;
PMAIP1	5	cellular response to hypoxia; protein binding; cellular response to glucose starvation; nucleus; cytosol;
RPTOR	5	insulin receptor signaling pathway; protein binding; cell cycle arrest; cellular response to nutrient levels; cytosol;
PIK3C3	5	insulin receptor signaling pathway; protein binding; protein kinase activity; ATP binding; cytosol;
SIK2	5	insulin receptor signaling pathway; protein binding; protein phosphorylation; nucleus; ATP binding;
IGF2	5	insulin receptor signaling pathway; glucose metabolic process; protein binding; positive regulation of cell proliferation; regulation of transcription, DNA-dependent;
BAIAP2	5	insulin receptor signaling pathway; protein binding; nucleus; protein C-terminus binding; cytosol;
PHKG2	5	glucose metabolic process; tau-protein kinase activity; protein phosphorylation; ATP binding; cytosol;
CTNND2	5	signal transduction; protein binding; transcription, DNA-dependent; nucleus; regulation of transcription, DNA-dependent;
LPXN	5	signal transduction; protein binding; transcription, DNA-dependent; nucleus; regulation of transcription, DNA-dependent;
NR4A2	5	signal transduction; protein binding; transcription, DNA-dependent; nucleus; response to hypoxia;
NEK6	5	signal transduction; protein binding; protein phosphorylation; nucleus; ATP binding;
FYB	5	signal transduction; protein binding; protein phosphorylation; nucleus; cytosol;
PRKG1	5	signal transduction; protein binding; protein phosphorylation; ATP binding; cytosol;
TXN	5	signal transduction; response to activity; protein binding; transcription, DNA-dependent; cytosol;
MAP2K3	5	signal transduction; activation of MAPK activity; protein binding; ATP binding; cytosol;
SMC3	5	signal transduction; protein binding; nucleus; ATP binding; chromatin binding;
ITK	5	signal transduction; protein binding; metal ion binding; ATP binding; cytosol;
ADRA2A	5	signal transduction; protein binding; positive regulation of cell proliferation; glucose homeostasis; negative regulation of lipid catabolic process;
ADRBK1	5	signal transduction; protein binding; protein kinase activity; ATP binding; cytosol;
TH	5	response to activity; protein binding; nucleus; cytosol; response to hypoxia;
MAP3K11	5	activation of MAPK activity; protein binding; protein phosphorylation; protein kinase activity; ATP binding;
STXBP3	5	protein binding; protein heterooligomerization; apical plasma membrane; nucleus; cytosol;
HABP4	5	protein binding; transcription, DNA-dependent; nucleus; regulation of transcription, DNA-dependent; cytosol;
HMGA1	5	protein binding; transcription, DNA-dependent; nucleus; regulation of transcription, DNA-dependent; cytosol;
CCND1	5	protein binding; nucleus; protein kinase activity; intracellular; cytosol;
JMJD1C	5	protein binding; transcription, DNA-dependent; metal ion binding; intracellular; regulation of transcription, DNA-dependent;
SYK	5	protein binding; protein phosphorylation; protein kinase activity; ATP binding; cytosol;
RQCD1	5	protein binding; transcription, DNA-dependent; nucleus; regulation of transcription, DNA-dependent; cytosol;
DAXX	5	protein binding; transcription, DNA-dependent; nucleus; regulation of transcription, DNA-dependent; cytosol;
WASL	5	protein binding; transcription, DNA-dependent; nucleus; regulation of transcription, DNA-dependent; cytosol;
KAT5	5	protein binding; transcription, DNA-dependent; nucleus; metal ion binding; cytosol;
AKAP7	5	protein binding; apical plasma membrane; nucleus; protein C-terminus binding; cytosol;
NEDD4L	5	protein binding; transcription, DNA-dependent; nucleus; intracellular; cytosol;
FRK	5	protein binding; protein phosphorylation; nucleus; intracellular; ATP binding;
RPS6KA4	5	protein binding; protein phosphorylation; nucleus; ATP binding; regulation of transcription, DNA-dependent;
ACACA	5	protein binding; fatty acid biosynthetic process; metal ion binding; ATP binding; cytosol;
IGHMBP2	5	protein binding; transcription, DNA-dependent; nucleus; ATP binding; regulation of transcription, DNA-dependent;
IL18	5	apical plasma membrane; cellular response to hydrogen peroxide; positive regulation of gene expression; cytosol; response to hypoxia;
RNASEL	5	protein phosphorylation; metal ion binding; protein kinase activity; ATP binding; cytosol;
HBP1	5	cell cycle arrest; transcription, DNA-dependent; nucleus; Wnt receptor signaling pathway; regulation of transcription, DNA-dependent;

Genes shared at least 2 KEGG pathways with PRKAA1 (count: 15)

Gene Symbol	Pathway Count	Pathway List
INS	3	Regulation of autophagy; Insulin signaling pathway; mTOR signaling pathway;
ULK2	2	Regulation of autophagy; mTOR signaling pathway;
PDPK1	2	Insulin signaling pathway; mTOR signaling pathway;
PRKAG3	2	Insulin signaling pathway; Adipocytokine signaling pathway;
PIK3R1	2	Insulin signaling pathway; mTOR signaling pathway;
TSC2	2	Insulin signaling pathway; mTOR signaling pathway;
PRKAB2	2	Insulin signaling pathway; Adipocytokine signaling pathway;
MAPK1	2	Insulin signaling pathway; mTOR signaling pathway;
TSC1	2	Insulin signaling pathway; mTOR signaling pathway;
MAPK9	2	Insulin signaling pathway; Adipocytokine signaling pathway;
PRKAG2	2	Insulin signaling pathway; Adipocytokine signaling pathway;
RPS6KB2	2	Insulin signaling pathway; mTOR signaling pathway;
PIK3CG	2	Insulin signaling pathway; mTOR signaling pathway;
MAPK3	2	Insulin signaling pathway; mTOR signaling pathway;
STK11	2	mTOR signaling pathway; Adipocytokine signaling pathway;

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Region: chr5:40759481..40798476 View in gBrowse