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- Data Summary
Gene Report
Approved Symbol | GSTP1 |
---|---|
Previous Symbol | FAEES3, GST3 |
Symbol Alias | GSTP |
Approved Name | glutathione S-transferase pi 1 |
Location | 11q13.2 |
Position | chr11:67351066-67354131, + |
External Links |
HGNC: 4638 Entrez Gene: 2950 Ensembl: ENSG00000084207 UCSC: uc001omf.2 |
No. of Studies | 0 (significant: 0; non-significant: 0; trend: 0) |
Source | Mapped by significant region |
Region Name | Position | No. of Studies (significant/non-significant/trend) |
---|---|---|
11q | chr11:53700000-135006516 | 2 (1/1/0) |
GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)
GO terms by database search (count: 42)
ID | Name | No. of Genes in ADHDgene | Brief Description |
---|---|---|---|
hsa05215 | Prostate cancer | 13 | Prostate cancer constitutes a major health problem in Wester...... Prostate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses (GSTP1), growth-factor-signaling pathways (NKX3.1, PTEN, and p27), and androgens (AR) as critical determinants of the phenotype of prostate-cancer cells. Glutathione S-transferases (GSTP1) are detoxifying enzymes. Cells of prostatic intraepithelial neoplasia, devoid of GSTP1, undergo genomic damage mediated by carcinogens. NKX3.1, PTEN, and p27 regulate the growth and survival of prostate cells in the normal prostate. Inadequate levels of PTEN and NKX3.1 lead to a reduction in p27 levels and to increased proliferation and decreased apoptosis. Androgen receptor (AR) is a transcription factor that is normally activated by its androgen ligand. During androgen withdrawal therapy, the AR signal transduction pathway also could be activated by amplification of the AR gene, by AR gene mutations, or by altered activity of AR coactivators. Through these mechanisms, tumor cells lead to the emergence of androgen-independent prostate cancer. More... |
hsa00480 | Glutathione metabolism | 9 | |
hsa00982 | Drug metabolism - cytochrome P450 | 29 | |
hsa05200 | Pathways in cancer | 52 | |
hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 26 |
Region: chr11:67351066..67354131 View in gBrowse
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014