ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GSTP1
Previous Symbol	FAEES3, GST3
Symbol Alias	GSTP
Approved Name	glutathione S-transferase pi 1
Location	11q13.2
Position	chr11:67351066-67354131, +
External Links	HGNC: 4638 Entrez Gene: 2950 Ensembl: ENSG00000084207 UCSC: uc001omf.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 42)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 42)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0002674	negative regulation of acute inflammatory response	Biological Process	NAS[18962899]	2
GO:0000302	response to reactive oxygen species	Biological Process		2
GO:0005515	protein binding	Molecular Function	IPI[16636664]	910
GO:0004364	glutathione transferase activity	Molecular Function	IDA[1540159]	5
GO:0070372	regulation of ERK1 and ERK2 cascade	Biological Process		4
GO:0070373	negative regulation of ERK1 and ERK2 cascade	Biological Process	IDA[11408560]	5
GO:0070664	negative regulation of leukocyte proliferation	Biological Process		1
GO:0071222	cellular response to lipopolysaccharide	Biological Process		13
GO:0071638	negative regulation of monocyte chemotactic protein-1 production	Biological Process	IDA[18962899]	2
GO:0097057	TRAF2-GSTP1 complex	Cellular Component	IDA[16636664]	1
GO:0070026	nitric oxide binding	Molecular Function	NAS[11533048]	1
GO:0060547	negative regulation of necrotic cell death	Biological Process		2
GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process	Biological Process	IDA[18962899]	1
GO:0048147	negative regulation of fibroblast proliferation	Biological Process		5
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0043508	negative regulation of JUN kinase activity	Biological Process	IDA[16636664]	2
GO:0043409	negative regulation of MAPK cascade	Biological Process	NAS[18962899]	5
GO:0043407	negative regulation of MAP kinase activity	Biological Process	IDA[11408560]	7
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process		5
GO:0043066	negative regulation of apoptotic process	Biological Process	IDA[16636664]; TAS[16130169]	77
GO:0035732	nitric oxide storage	Biological Process	NAS[12871931]	1
GO:0035731	dinitrosyl-iron complex binding	Molecular Function	IDA[11533048]	1
GO:0035730	S-nitrosoglutathione binding	Molecular Function	IDA[11533048]	1
GO:0035726	common myeloid progenitor cell proliferation	Biological Process		1
GO:0032930	positive regulation of superoxide anion generation	Biological Process		2
GO:0032873	negative regulation of stress-activated MAPK cascade	Biological Process		1
GO:0032720	negative regulation of tumor necrosis factor production	Biological Process	IDA[18962899]	6
GO:0032872	regulation of stress-activated MAPK cascade	Biological Process		4
GO:0019207	kinase regulator activity	Molecular Function		1
GO:0032691	negative regulation of interleukin-1 beta production	Biological Process	IDA[18962899]	3
GO:0009890	negative regulation of biosynthetic process	Biological Process	IDA[18962899]	1
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	Biological Process	IC[16636664]	2
GO:0007417	central nervous system development	Biological Process	TAS[9802272]	22
GO:0008432	JUN kinase binding	Molecular Function		1
GO:0006749	glutathione metabolic process	Biological Process	IDA[1540159]	7
GO:0006805	xenobiotic metabolic process	Biological Process	IDA[1540159]	25
GO:0005829	cytosol	Cellular Component		447
GO:0006469	negative regulation of protein kinase activity	Biological Process	IDA[16636664]	13
GO:0005737	cytoplasm	Cellular Component	TAS[16130169]	690
GO:0005739	mitochondrion	Cellular Component		183
GO:0005622	intracellular	Cellular Component	IDA[18962899]	67
GO:0005634	nucleus	Cellular Component		770

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05215	Prostate cancer	13	Prostate cancer constitutes a major health problem in Wester...... Prostate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses (GSTP1), growth-factor-signaling pathways (NKX3.1, PTEN, and p27), and androgens (AR) as critical determinants of the phenotype of prostate-cancer cells. Glutathione S-transferases (GSTP1) are detoxifying enzymes. Cells of prostatic intraepithelial neoplasia, devoid of GSTP1, undergo genomic damage mediated by carcinogens. NKX3.1, PTEN, and p27 regulate the growth and survival of prostate cells in the normal prostate. Inadequate levels of PTEN and NKX3.1 lead to a reduction in p27 levels and to increased proliferation and decreased apoptosis. Androgen receptor (AR) is a transcription factor that is normally activated by its androgen ligand. During androgen withdrawal therapy, the AR signal transduction pathway also could be activated by amplification of the AR gene, by AR gene mutations, or by altered activity of AR coactivators. Through these mechanisms, tumor cells lead to the emergence of androgen-independent prostate cancer. More...
hsa00480	Glutathione metabolism	9
hsa00982	Drug metabolism - cytochrome P450	29
hsa05200	Pathways in cancer	52
hsa00980	Metabolism of xenobiotics by cytochrome P450	26

Genes shared at least 5 GO terms with GSTP1 (count: 37)

Gene Symbol	Pathway Count	Pathway List
TNFAIP3	9	protein binding; cellular response to lipopolysaccharide; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of apoptotic process; negative regulation of tumor necrosis factor production; negative regulation of interleukin-1 beta production; cytosol; cytoplasm; nucleus;
PYCARD	7	protein binding; cellular response to lipopolysaccharide; negative regulation of I-kappaB kinase/NF-kappaB cascade; cytosol; cytoplasm; mitochondrion; nucleus;
APC	6	protein binding; negative regulation of MAPK cascade; negative regulation of apoptotic process; cytosol; cytoplasm; nucleus;
ARRB2	6	protein binding; negative regulation of tumor necrosis factor production; negative regulation of interleukin-1 beta production; cytosol; cytoplasm; nucleus;
CRYAB	6	protein binding; negative regulation of apoptotic process; cytosol; cytoplasm; mitochondrion; nucleus;
GSK3B	6	protein binding; negative regulation of MAP kinase activity; negative regulation of apoptotic process; cytosol; cytoplasm; nucleus;
MAPK1	6	protein binding; regulation of stress-activated MAPK cascade; cytosol; cytoplasm; mitochondrion; nucleus;
PARK2	6	protein binding; central nervous system development; cytosol; cytoplasm; mitochondrion; nucleus;
RELA	6	protein binding; cellular response to lipopolysaccharide; negative regulation of apoptotic process; cytosol; cytoplasm; nucleus;
SNCA	6	protein binding; negative regulation of apoptotic process; cytosol; cytoplasm; mitochondrion; nucleus;
TH	6	protein binding; small molecule metabolic process; cytosol; cytoplasm; mitochondrion; nucleus;
AIP	5	protein binding; xenobiotic metabolic process; cytosol; cytoplasm; nucleus;
BNIP3	5	protein binding; negative regulation of apoptotic process; cytoplasm; mitochondrion; nucleus;
CBL	5	protein binding; negative regulation of apoptotic process; cytosol; cytoplasm; nucleus;
DCPS	5	protein binding; cytosol; cytoplasm; mitochondrion; nucleus;
HK1	5	protein binding; small molecule metabolic process; cytosol; mitochondrion; nucleus;
INPPL1	5	protein binding; small molecule metabolic process; negative regulation of MAP kinase activity; cytosol; cytoplasm;
MALT1	5	protein binding; negative regulation of apoptotic process; cytosol; cytoplasm; nucleus;
MAPK3	5	protein binding; regulation of stress-activated MAPK cascade; cytosol; mitochondrion; nucleus;
MAPK9	5	protein binding; cellular response to lipopolysaccharide; central nervous system development; cytosol; mitochondrion;
MTMR2	5	protein binding; small molecule metabolic process; cytosol; cytoplasm; nucleus;
NEDD4L	5	protein binding; cytosol; cytoplasm; intracellular; nucleus;
NF2	5	protein binding; negative regulation of MAPK cascade; negative regulation of protein kinase activity; cytoplasm; nucleus;
PDCD4	5	protein binding; negative regulation of JUN kinase activity; cytosol; cytoplasm; nucleus;
PIK3CG	5	protein binding; small molecule metabolic process; negative regulation of apoptotic process; cytosol; cytoplasm;
PMAIP1	5	protein binding; negative regulation of fibroblast proliferation; cytosol; mitochondrion; nucleus;
PPP1CA	5	protein binding; small molecule metabolic process; cytosol; cytoplasm; nucleus;
PRKAA1	5	protein binding; negative regulation of apoptotic process; cytosol; intracellular; nucleus;
PRKD1	5	protein binding; small molecule metabolic process; cytosol; cytoplasm; nucleus;
PSMC3	5	protein binding; small molecule metabolic process; cytosol; cytoplasm; nucleus;
TLR4	5	protein binding; negative regulation of ERK1 and ERK2 cascade; cellular response to lipopolysaccharide; negative regulation of tumor necrosis factor production; cytoplasm;
TRIM32	5	protein binding; negative regulation of fibroblast proliferation; negative regulation of apoptotic process; cytoplasm; nucleus;
WWOX	5	protein binding; cytosol; cytoplasm; mitochondrion; nucleus;
WWP1	5	protein binding; central nervous system development; cytosol; cytoplasm; nucleus;
YAP1	5	protein binding; negative regulation of apoptotic process; cytosol; cytoplasm; nucleus;
PTS	5	small molecule metabolic process; central nervous system development; cytosol; cytoplasm; mitochondrion;
SHMT1	5	small molecule metabolic process; cytosol; cytoplasm; mitochondrion; nucleus;

Genes shared at least 2 KEGG pathways with GSTP1 (count: 34)

Gene Symbol	Pathway Count	Pathway List
GSTT1	3	Glutathione metabolism; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
GSTT2	3	Glutathione metabolism; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
BAD	2	Prostate cancer; Pathways in cancer;
CCND1	2	Prostate cancer; Pathways in cancer;
ERBB2	2	Prostate cancer; Pathways in cancer;
GSK3B	2	Prostate cancer; Pathways in cancer;
MAPK1	2	Prostate cancer; Pathways in cancer;
MAPK3	2	Prostate cancer; Pathways in cancer;
PIK3CG	2	Prostate cancer; Pathways in cancer;
PIK3R1	2	Prostate cancer; Pathways in cancer;
RELA	2	Prostate cancer; Pathways in cancer;
ALDH3A1	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
ALDH3B1	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
ALDH3B2	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
CYP2E1	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT1A1	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT1A10	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT1A3	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT1A4	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT1A5	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT1A6	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT1A7	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT1A8	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT1A9	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2A1	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2A2	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2A3	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2B10	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2B11	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2B15	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2B17	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2B28	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2B4	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2B7	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;

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Region: chr11:67351066..67354131 View in gBrowse