ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	UGT1A4
Symbol Alias	HUG-BR2, UGT1D
Approved Name	UDP glucuronosyltransferase 1 family, polypeptide A4
Previous Name	"UDP glycosyltransferase 1 family, polypeptide A4"
Location	2q37.1
Position	chr2:234627424-234681945, 1
External Links	HGNC: 12536 Entrez Gene: 54657 Ensembl: ENSG00000244474 UCSC: uc002vux.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 41)

Literature-origin SNPs (count: 0)

LD-proxies (count: 41)

rs_ID	Location	Functional Annotation
rs12479045	chr2:234673588(Fwd)	intron_variant; NMD_transcript_variant
rs17868342	chr2:234673516(Fwd)	intron_variant; NMD_transcript_variant
rs1018124	chr2:234676118(Fwd)	downstream_gene_variant; intron_variant; NMD_transcript_variant
rs4663968	chr2:234655144(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs12466997	chr2:234656517(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant; upstream_gene_variant
rs17863798	chr2:234656735(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs17862878	chr2:234661948(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant
rs12052787	chr2:234666581(Fwd)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant
rs2003569	chr2:234667937(Fwd)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant
rs17864705	chr2:234672328(Fwd)	intron_variant; NMD_transcript_variant
rs3771342	chr2:234672663(Fwd)	intron_variant; NMD_transcript_variant
rs10929293	chr2:234630186(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant
rs12479208	chr2:234630900(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs28899187	chr2:234630967(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs28898615	chr2:234631007(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs28899189	chr2:234634324(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs28898621	chr2:234639211(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant
rs4663964	chr2:234650236(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant
rs3796088	chr2:234651800(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant; upstream_gene_variant
rs28899186	chr2:234629585(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant
rs12468543	chr2:234629239(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant
rs12468356	chr2:234628747(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant
rs12463641	chr2:234628715(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant
rs12466779	chr2:234628694(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant
rs904856	chr2:234628647(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant
rs904855	chr2:234628576(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant
rs3732218	chr2:234627304(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs3732220	chr2:234627048(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs3732221	chr2:234627010(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs3806591	chr2:234626199(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs3806593	chr2:234625919(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs3806594	chr2:234625890(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs3806595	chr2:234625718(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs28898605	chr2:234625494(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs17874943	chr2:234625239(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs17863791	chr2:234624884(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs17863792	chr2:234625126(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs12477216	chr2:234623667(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs17868334	chr2:234624817(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs17862870	chr2:234622742(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs4663945	chr2:234623117(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0005789	endoplasmic reticulum membrane	cellular component	TAS	159
GO:0019899	enzyme binding	molecular function	IDA	54
GO:0015020	glucuronosyltransferase activity	molecular function	IEA	20
GO:0046982	protein heterodimerization activity	molecular function	IPI	73
GO:0006805	xenobiotic metabolic process	biological process	TAS	26
GO:0001972	retinoic acid binding	molecular function	IDA	12
GO:0042803	protein homodimerization activity	molecular function	IPI	128
GO:0005783	endoplasmic reticulum	cellular component	TAS[1898728]	111
GO:0016021	integral to membrane	cellular component	IEA	932

Gene related KEGG pathways (count: 8)

ID	Name	No. of Genes in ADHDgene
hsa00860	Porphyrin and chlorophyll metabolism	24
hsa00830	Retinol metabolism	19
hsa00040	Pentose and glucuronate interconversions	17
hsa00982	Drug metabolism - cytochrome P450	27
hsa00983	Drug metabolism - other enzymes	22
hsa00980	Metabolism of xenobiotics by cytochrome P450	24
hsa00500	Starch and sucrose metabolism	27
hsa00150	Androgen and estrogen metabolism	24

Genes shared at least 5 GO terms with UGT1A4 (count: 11)

Gene Symbol	Pathway Count	Pathway List
UGT1A9	9	small molecule metabolic process; endoplasmic reticulum membrane; enzyme binding; glucuronosyltransferase activity; protein heterodimerization activity; xenobiotic metabolic process; retinoic acid binding; protein homodimerization activity; integral to membrane;
UGT1A6	9	small molecule metabolic process; endoplasmic reticulum membrane; enzyme binding; glucuronosyltransferase activity; protein heterodimerization activity; xenobiotic metabolic process; retinoic acid binding; protein homodimerization activity; integral to membrane;
UGT1A1	8	small molecule metabolic process; endoplasmic reticulum membrane; enzyme binding; glucuronosyltransferase activity; protein heterodimerization activity; xenobiotic metabolic process; retinoic acid binding; protein homodimerization activity;
UGT1A10	8	endoplasmic reticulum membrane; enzyme binding; glucuronosyltransferase activity; protein heterodimerization activity; retinoic acid binding; protein homodimerization activity; endoplasmic reticulum; integral to membrane;
UGT1A7	8	endoplasmic reticulum membrane; enzyme binding; glucuronosyltransferase activity; protein heterodimerization activity; retinoic acid binding; protein homodimerization activity; endoplasmic reticulum; integral to membrane;
UGT1A8	7	endoplasmic reticulum membrane; enzyme binding; glucuronosyltransferase activity; protein heterodimerization activity; retinoic acid binding; protein homodimerization activity; integral to membrane;
UGT1A3	7	endoplasmic reticulum membrane; enzyme binding; glucuronosyltransferase activity; protein heterodimerization activity; retinoic acid binding; protein homodimerization activity; integral to membrane;
DGAT2	5	small molecule metabolic process; endoplasmic reticulum membrane; protein homodimerization activity; endoplasmic reticulum; integral to membrane;
UGT2B4	5	endoplasmic reticulum membrane; glucuronosyltransferase activity; xenobiotic metabolic process; retinoic acid binding; integral to membrane;
UGT2B28	5	endoplasmic reticulum membrane; glucuronosyltransferase activity; xenobiotic metabolic process; endoplasmic reticulum; integral to membrane;
UGT2B15	5	endoplasmic reticulum membrane; glucuronosyltransferase activity; xenobiotic metabolic process; retinoic acid binding; integral to membrane;

Genes shared at least 2 KEGG pathways with UGT1A4 (count: 23)

Gene Symbol	Pathway Count	Pathway List
UGT1A10	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT2B15	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT1A8	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT1A1	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT2B10	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT2B28	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT1A6	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT1A7	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT2B7	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT2B11	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT1A3	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT2B17	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT2B4	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT2A3	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT1A9	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT1A5	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
CYP2E1	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
GSTT1	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
GSTP1	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
ALDH3A1	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
ALDH3B2	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
GSTT2	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
ALDH3B1	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;

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Region: chr2:234627424..234681945 View in gBrowse