ADHDgene Database

Gene Report

Basic Info

Approved Symbol	PTS
Symbol Alias	PTPS
Approved Name	6-pyruvoyltetrahydropterin synthase
Location	11q22.3
Position	chr11:112097088-112140678, +
External Links	HGNC: 9689 Entrez Gene: 5805 Ensembl: ENSG00000150787 UCSC: uc001pnj.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0050999	regulation of nitric-oxide synthase activity	Biological Process		5
GO:0046872	metal ion binding	Molecular Function		170
GO:0003874	6-pyruvoyltetrahydropterin synthase activity	Molecular Function		1
GO:0005737	cytoplasm	Cellular Component		690
GO:0005739	mitochondrion	Cellular Component		183
GO:0042802	identical protein binding	Molecular Function	IPI[16189514]	70
GO:0042803	protein homodimerization activity	Molecular Function		113
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0046209	nitric oxide metabolic process	Biological Process		4
GO:0005829	cytosol	Cellular Component		447
GO:0006520	cellular amino acid metabolic process	Biological Process	TAS[3308682]	8
GO:0006729	tetrahydrobiopterin biosynthetic process	Biological Process		1
GO:0007417	central nervous system development	Biological Process	TAS[3308682]	22

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00790	Folate biosynthesis	1
hsa01100	Metabolic pathways	237

Genes shared at least 5 GO terms with PTS (count: 5)

Gene Symbol	Pathway Count	Pathway List
LYPLA1	5	regulation of nitric-oxide synthase activity; mitochondrion; small molecule metabolic process; nitric oxide metabolic process; cytosol;
CRYAB	5	metal ion binding; cytoplasm; mitochondrion; protein homodimerization activity; cytosol;
PRKD1	5	metal ion binding; cytoplasm; identical protein binding; small molecule metabolic process; cytosol;
GSTP1	5	cytoplasm; mitochondrion; small molecule metabolic process; cytosol; central nervous system development;
SHMT1	5	cytoplasm; mitochondrion; protein homodimerization activity; small molecule metabolic process; cytosol;

Genes shared at least 2 KEGG pathways with PTS (count: 0)

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Region: chr11:112097088..112140678 View in gBrowse