ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	UGT1A1
Previous Symbol	UGT1, GNT1
Symbol Alias	UGT1A
Approved Name	UDP glucuronosyltransferase 1 family, polypeptide A1
Previous Name	"UDP glycosyltransferase 1 family, polypeptide A1"
Location	2q37.1
Position	chr2:234526291-234681956, 1
External Links	HGNC: 12530 Entrez Gene: 54658 Ensembl: ENSG00000242366
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 7)

Literature-origin SNPs (count: 0)

LD-proxies (count: 7)

rs_ID	Location	Functional Annotation
rs12052787	chr2:234666581(Fwd)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant
rs2003569	chr2:234667937(Fwd)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant
rs17864705	chr2:234672328(Fwd)	intron_variant; NMD_transcript_variant
rs3771342	chr2:234672663(Fwd)	intron_variant; NMD_transcript_variant
rs12479045	chr2:234673588(Fwd)	intron_variant; NMD_transcript_variant
rs17868342	chr2:234673516(Fwd)	intron_variant; NMD_transcript_variant
rs1018124	chr2:234676118(Fwd)	downstream_gene_variant; intron_variant; NMD_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 36)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 36)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0042167	heme catabolic process	biological process	TAS	3
GO:0032496	response to lipopolysaccharide	biological process	IEA	23
GO:0070069	cytochrome complex	cellular component	IEA	1
GO:0052697	xenobiotic glucuronidation	biological process	IDA	5
GO:0031100	organ regeneration	biological process	IEA	11
GO:0005496	steroid binding	molecular function	IDA[19996319]	8
GO:0007586	digestion	biological process	NAS[1898728]	13
GO:0042493	response to drug	biological process	IEA	73
GO:0071385	cellular response to glucocorticoid stimulus	biological process	IEA	2
GO:0043086	negative regulation of catalytic activity	biological process	IDA[19996319]	7
GO:0071361	cellular response to ethanol	biological process	IEA	3
GO:0051552	flavone metabolic process	biological process	IDA[18052087]	5
GO:0008202	steroid metabolic process	biological process	IC[19996319]	16
GO:0007584	response to nutrient	biological process	IEA	18
GO:0046982	protein heterodimerization activity	molecular function	IPI	73
GO:0001972	retinoic acid binding	molecular function	IDA	12
GO:0004857	enzyme inhibitor activity	molecular function	IDA[19996319]	9
GO:0052696	flavonoid glucuronidation	biological process	IDA	5
GO:0006953	acute-phase response	biological process	IEA	12
GO:0006805	xenobiotic metabolic process	biological process	TAS	26
GO:0015020	glucuronosyltransferase activity	molecular function	IDA; TAS	20
GO:0005789	endoplasmic reticulum membrane	cellular component	TAS	159
GO:0005887	integral to plasma membrane	cellular component	IEA	236
GO:0042594	response to starvation	biological process	IEA	6
GO:0070980	biphenyl catabolic process	biological process	IEA	1
GO:0017144	drug metabolic process	biological process	IC[19996319]	8
GO:0046483	heterocycle metabolic process	biological process	IC[19996319]	2
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0042803	protein homodimerization activity	molecular function	IPI	128
GO:0001889	liver development	biological process	IEA	16
GO:0042573	retinoic acid metabolic process	biological process	IC	7
GO:0006789	bilirubin conjugation	biological process	TAS[1339448]	1
GO:0019899	enzyme binding	molecular function	IDA	54
GO:0008210	estrogen metabolic process	biological process	TAS[8780690]	3
GO:0006778	porphyrin-containing compound metabolic process	biological process	TAS	6
GO:0045939	negative regulation of steroid metabolic process	biological process	IC[19996319]	2

Gene related KEGG pathways (count: 8)

ID	Name	No. of Genes in ADHDgene
hsa00860	Porphyrin and chlorophyll metabolism	24
hsa00830	Retinol metabolism	19
hsa00040	Pentose and glucuronate interconversions	17
hsa00982	Drug metabolism - cytochrome P450	27
hsa00983	Drug metabolism - other enzymes	22
hsa00980	Metabolism of xenobiotics by cytochrome P450	24
hsa00500	Starch and sucrose metabolism	27
hsa00150	Androgen and estrogen metabolism	24

Genes shared at least 5 GO terms with UGT1A1 (count: 15)

Gene Symbol	Pathway Count	Pathway List
UGT1A8	16	xenobiotic glucuronidation; steroid binding; negative regulation of catalytic activity; flavone metabolic process; steroid metabolic process; protein heterodimerization activity; retinoic acid binding; enzyme inhibitor activity; flavonoid glucuronidation; glucuronosyltransferase activity; endoplasmic reticulum membrane; drug metabolic process; protein homodimerization activity; retinoic acid metabolic process; enzyme binding; negative regulation of steroid metabolic process;
UGT1A9	15	xenobiotic glucuronidation; negative regulation of catalytic activity; flavone metabolic process; protein heterodimerization activity; retinoic acid binding; enzyme inhibitor activity; flavonoid glucuronidation; xenobiotic metabolic process; glucuronosyltransferase activity; endoplasmic reticulum membrane; drug metabolic process; small molecule metabolic process; protein homodimerization activity; retinoic acid metabolic process; enzyme binding;
UGT1A7	13	xenobiotic glucuronidation; negative regulation of catalytic activity; flavone metabolic process; protein heterodimerization activity; retinoic acid binding; enzyme inhibitor activity; flavonoid glucuronidation; glucuronosyltransferase activity; endoplasmic reticulum membrane; drug metabolic process; protein homodimerization activity; retinoic acid metabolic process; enzyme binding;
UGT1A3	9	xenobiotic glucuronidation; protein heterodimerization activity; retinoic acid binding; flavonoid glucuronidation; glucuronosyltransferase activity; endoplasmic reticulum membrane; protein homodimerization activity; retinoic acid metabolic process; enzyme binding;
CYP2E1	8	response to drug; steroid metabolic process; xenobiotic metabolic process; endoplasmic reticulum membrane; drug metabolic process; heterocycle metabolic process; small molecule metabolic process; enzyme binding;
UGT1A6	8	protein heterodimerization activity; retinoic acid binding; xenobiotic metabolic process; glucuronosyltransferase activity; endoplasmic reticulum membrane; small molecule metabolic process; protein homodimerization activity; enzyme binding;
UGT1A4	8	protein heterodimerization activity; retinoic acid binding; xenobiotic metabolic process; glucuronosyltransferase activity; endoplasmic reticulum membrane; small molecule metabolic process; protein homodimerization activity; enzyme binding;
UGT1A10	7	flavone metabolic process; protein heterodimerization activity; retinoic acid binding; glucuronosyltransferase activity; endoplasmic reticulum membrane; protein homodimerization activity; enzyme binding;
MAOB	5	response to lipopolysaccharide; response to drug; xenobiotic metabolic process; small molecule metabolic process; protein homodimerization activity;
COMT	5	response to lipopolysaccharide; response to drug; xenobiotic metabolic process; small molecule metabolic process; estrogen metabolic process;
APOA1	5	organ regeneration; response to drug; response to nutrient; small molecule metabolic process; enzyme binding;
OXCT1	5	response to drug; response to nutrient; response to starvation; small molecule metabolic process; protein homodimerization activity;
CYP17A1	5	response to drug; steroid metabolic process; xenobiotic metabolic process; endoplasmic reticulum membrane; small molecule metabolic process;
UGT2B15	5	steroid metabolic process; retinoic acid binding; xenobiotic metabolic process; glucuronosyltransferase activity; endoplasmic reticulum membrane;
ACAT1	5	response to starvation; small molecule metabolic process; protein homodimerization activity; liver development; enzyme binding;

Genes shared at least 2 KEGG pathways with UGT1A1 (count: 23)

Gene Symbol	Pathway Count	Pathway List
UGT1A10	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT2B15	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT1A8	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT1A4	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT2B10	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT2B28	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT1A6	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT1A7	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT2B7	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT2B11	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT1A3	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT2B17	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT2B4	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT2A3	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT1A9	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
UGT1A5	8	Porphyrin and chlorophyll metabolism; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Drug metabolism - other enzymes; Metabolism of xenobiotics by cytochrome P450; Starch and sucrose metabolism; Androgen and estrogen metabolism;
CYP2E1	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
GSTT1	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
GSTP1	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
ALDH3A1	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
ALDH3B2	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
GSTT2	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
ALDH3B1	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;

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Region: chr2:234526291..234681956 View in gBrowse