ADHDgene Database

Gene Report

Basic Info

Approved Symbol	HMBS
Previous Symbol	PBGD, UPS, PORC
Approved Name	hydroxymethylbilane synthase
Previous Name	uroporphyrinogen I synthase, "porphobilinogen deaminase", "porphyria, acute; Chester type"
Location	11q23.2-qter
Position	chr11:118955587-118964259, +
External Links	HGNC: 4982 Entrez Gene: 3145 UCSC: uc001puz.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0006783	heme biosynthetic process	Biological Process	IC[18004775]	3
GO:0018160	peptidyl-pyrromethane cofactor linkage	Biological Process		1
GO:0006778	porphyrin-containing compound metabolic process	Biological Process		4
GO:0006782	protoporphyrinogen IX biosynthetic process	Biological Process		3
GO:0004418	hydroxymethylbilane synthase activity	Molecular Function	IDA[18004775]	1
GO:0005829	cytosol	Cellular Component		447

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00860	Porphyrin and chlorophyll metabolism	24

Genes shared at least 5 GO terms with HMBS (count: 1)

Gene Symbol	Pathway Count	Pathway List
ALAD	5	small molecule metabolic process; heme biosynthetic process; porphyrin-containing compound metabolic process; protoporphyrinogen IX biosynthetic process; cytosol;

Genes shared at least 2 KEGG pathways with HMBS (count: 22)

Gene Symbol	Pathway Count	Pathway List
ALAD	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
EARS2	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
FECH	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A1	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A10	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A3	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A4	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A5	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A6	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A7	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A8	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A9	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2A1	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2A2	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2A3	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B10	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B11	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B15	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B17	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B28	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B4	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B7	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;

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Region: chr11:118955587..118964259 View in gBrowse