ADHDgene Database

Gene Report

Basic Info

Approved Symbol	EARS2
Symbol Alias	KIAA1970, MSE1
Approved Name	glutamyl-tRNA synthetase 2, mitochondrial (putative)
Name Alias	glutamate tRNA ligase 2, mitochondrial (putative)
Location	16p12.3
Position	chr16:23533334-23568696, -
External Links	HGNC: 29419 Entrez Gene: 124454 Ensembl: ENSG00000103356 UCSC: uc002dlt.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16p12.3-12.2	chr16:16800000-24200000	1 (1/0/0)

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004818	glutamate-tRNA ligase activity	Molecular Function	IDA[19805282]	1
GO:0003723	RNA binding	Molecular Function		104
GO:0006424	glutamyl-tRNA aminoacylation	Biological Process	IDA[19805282]	1
GO:0010467	gene expression	Biological Process		140
GO:0050561	glutamate-tRNA(Gln) ligase activity	Molecular Function	IDA[19805282]	1
GO:0070127	tRNA aminoacylation for mitochondrial protein translation	Biological Process	IDA[19805282]	1
GO:0005524	ATP binding	Molecular Function		228
GO:0005739	mitochondrion	Cellular Component	IDA[19805282]	183
GO:0005759	mitochondrial matrix	Cellular Component		32
GO:0006418	tRNA aminoacylation for protein translation	Biological Process		8

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene
hsa01100	Metabolic pathways	237
hsa00970	Aminoacyl-tRNA biosynthesis	10
hsa00860	Porphyrin and chlorophyll metabolism	24

Genes shared at least 5 GO terms with EARS2 (count: 4)

Gene Symbol	Pathway Count	Pathway List
SARS	5	RNA binding; gene expression; ATP binding; mitochondrion; tRNA aminoacylation for protein translation;
DARS2	5	gene expression; ATP binding; mitochondrion; mitochondrial matrix; tRNA aminoacylation for protein translation;
KARS	5	gene expression; ATP binding; mitochondrion; mitochondrial matrix; tRNA aminoacylation for protein translation;
NARS2	5	gene expression; ATP binding; mitochondrion; mitochondrial matrix; tRNA aminoacylation for protein translation;

Genes shared at least 2 KEGG pathways with EARS2 (count: 22)

Gene Symbol	Pathway Count	Pathway List
ALAD	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
FECH	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
HMBS	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A1	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A10	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A3	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A4	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A5	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A6	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A7	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A8	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A9	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2A1	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2A2	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2A3	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B10	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B11	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B15	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B17	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B28	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B4	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B7	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;

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Region: chr16:23533334..23568696 View in gBrowse