ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HSD17B2
Symbol Alias	HSD17, SDR9C2
Approved Name	hydroxysteroid (17-beta) dehydrogenase 2
Name Alias	short chain dehydrogenase/reductase family 9C, member 2
Location	16q24.1-q24.2
Position	chr16:82068858-82132139, +
External Links	HGNC: 5211 Entrez Gene: 3294 Ensembl: ENSG00000086696 UCSC: uc002fgv.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16q23.1-24.3	chr16:74100000-90354753	1 (1/0/0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000166	nucleotide binding	Molecular Function		73
GO:0001701	in utero embryonic development	Biological Process		32
GO:0001890	placenta development	Biological Process		2
GO:0004303	estradiol 17-beta-dehydrogenase activity	Molecular Function	IDA[17538076]	1
GO:0005789	endoplasmic reticulum membrane	Cellular Component	TAS[8099587]	140
GO:0006694	steroid biosynthetic process	Biological Process		4
GO:0016021	integral to membrane	Cellular Component		845
GO:0032526	response to retinoic acid	Biological Process	IDA[17538076]	7
GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Molecular Function	TAS[17538076]	1
GO:0047035	testosterone dehydrogenase (NAD+) activity	Molecular Function		1
GO:0050327	testosterone 17-beta-dehydrogenase (NAD+) activity	Molecular Function	IDA[8099587]	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00140	Steroid hormone biosynthesis	24	Steroid hormones derived from cholesterol are a class of bio...... Steroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 compound, to the first C21 steroid, pregnenolone, which is converted by a bifunctional enzyme complex to the gestagen hormone, progesterone [MD:M00107]. Pregnenolone and progesterone are the starting materials for the three groups of steroids: C21 steroids of glucocorticoids and mineralocorticoids, C19 steroids of androgens, and C18 steroids of estrogens. (i) Progesterone is converted by hydroxylations at carbons 21 and 11 to corticosterone, which is further modified by hydroxylation and oxydoreduction at carbon 18 to yield aldosterone, a mineralcorticoid [MD:M00108]. Cortisol, the main glucocorticoid, is formed from 17alpha-hydroxyprogesterone with 11-deoxycortisol as an intermediate [MD:M00109]. (ii) Male hormone testosterone is formed from pregnenolone by two pathways, delta5 pathway via dehydroepiandrosterone and delta4 pathway via androstenedione [MD:M00110]. The enzyme CYP17A1 is responsible for the 17,20 lyase and 17alpha-hydroxylase activities in respective pathways. (iii) Female hormones estrone and estradiol are formed from testosterone and 4-androstene-3,17-dione by oxidative removal of the C19 methyl group and subsequent aromatization of ring A [MD:M00111]. In addition to these three groups, recent studies show that there is another group, termed neurosteroids, synthesized in the brain rather than the peripheral endocrine gland. More...

Genes shared at least 5 GO terms with HSD17B2 (count: 0)

Genes shared at least 2 KEGG pathways with HSD17B2 (count: 21)

Gene Symbol	Pathway Count	Pathway List
COMT	2	Metabolic pathways; Steroid hormone biosynthesis;
HSD17B3	2	Metabolic pathways; Steroid hormone biosynthesis;
UGT1A1	2	Metabolic pathways; Steroid hormone biosynthesis;
UGT1A10	2	Metabolic pathways; Steroid hormone biosynthesis;
UGT1A3	2	Metabolic pathways; Steroid hormone biosynthesis;
UGT1A4	2	Metabolic pathways; Steroid hormone biosynthesis;
UGT1A5	2	Metabolic pathways; Steroid hormone biosynthesis;
UGT1A6	2	Metabolic pathways; Steroid hormone biosynthesis;
UGT1A7	2	Metabolic pathways; Steroid hormone biosynthesis;
UGT1A8	2	Metabolic pathways; Steroid hormone biosynthesis;
UGT1A9	2	Metabolic pathways; Steroid hormone biosynthesis;
UGT2A1	2	Metabolic pathways; Steroid hormone biosynthesis;
UGT2A2	2	Metabolic pathways; Steroid hormone biosynthesis;
UGT2A3	2	Metabolic pathways; Steroid hormone biosynthesis;
UGT2B10	2	Metabolic pathways; Steroid hormone biosynthesis;
UGT2B11	2	Metabolic pathways; Steroid hormone biosynthesis;
UGT2B15	2	Metabolic pathways; Steroid hormone biosynthesis;
UGT2B17	2	Metabolic pathways; Steroid hormone biosynthesis;
UGT2B28	2	Metabolic pathways; Steroid hormone biosynthesis;
UGT2B4	2	Metabolic pathways; Steroid hormone biosynthesis;
UGT2B7	2	Metabolic pathways; Steroid hormone biosynthesis;

View in gBrowse

Region: chr16:82068858..82132139 View in gBrowse